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Twenty years of research have yielded our most advanced and comprehensive night treatment cream. This ultra-rich moisturizer works overnight to nourish skin with essential hydration and over time actively fights the appearance of deep lines and wrinkles, including nasolabial folds and marionette lines. Wake up to dramatically younger, smoother, healthier-looking skin.

What It Does

  • Addresses the 4-types of wrinkles: Fine Lines, Static Wrinkles, Dynamic Wrinkles and Gravitational Wrinkles.
  • Works with the body’s natural repair cycle to help rejuvenate the skin and deliver visible results night after night.
  • Visibly and dramatically softens the appearance of deep lines and creases.
  • Nourishes the skin with essential hydration.

What To Expect

Due to the science and compounds used in our products the feel and scent may vary.

Texture: Cream

Consistency: Luxurious & Rich

Scent: Natural

* This product is free from fish, milk, phthalates, sulfates, parabens, talc, and mineral oil. Cruelty-free and 100% vegan.

Consumer Results

93% agreed skin looked and felt more supple*
91% agreed skin looked and felt smoother*
83% agreed skin appeared rested, renewed and restored*
83% agreed they saw improvement in the appearance of surface fine lines*
78% agreed they saw improvement in the appearance of static and stubborn wrinkles*
*In a consumer study of 54 women after 28 days.

Neuropeptides: Uniting Surface Cells to Fight Wrinkles

owerful, protein-like building blocks offer the ultimate visible antidote to the look of wrinkles, sagging, dullness and discoloration. Neuropeptides support skin’s barrier and hydration via a unique chemical structure.

DMAE: Intensive Firming

Naturally produced by the human brain, DMAE helps visibly lift sagging skin over time. Easily and quickly absorbed, it visibly plumps skin to help support skin’s surface and protect against drying environmental aggressors.

Amino Acids: Build Stronger Skin

Organic compounds that make up over 20% of the human body, amino acids hydrate for firmer, smoother looking skin, help strengthen surface skin cells and have been used for a variety of skin benefits.

Ingredients:

Water/Aqua/Eau, Glycerin, Isononyl Isononanoate, Pentaerythrityl Tetraethylhexanoate, Cetearyl Alcohol, Butyrospermum Parkii (Shea) Butter, C12-20 Acid PEG-8 Ester, Dimethyl Isosorbide, C10-18 Triglycerides, Isodecyl Salicylate, Butylene Glycol, Hydroxyethyl Acrylate/Sodium Acryloyldimethyl Taurate Copolymer, Squalane, C12-15 Alkyl Benzoate, Dimethicone, Polymethyl Methacrylate, Dimethyl MEA, Acetyl Hexapeptide-8, Pentapeptide-18, Tetrapeptide-21, Dipeptide-2, Palmitoyl Tetrapeptide-7, Palmitoyl Hexapeptide-12, Tyrosine, Tocopheryl Acetate, Dipotassium Glycyrrhizate, Hesperidin Methyl Chalcone, Ceramide NG, Fructose, Allantoin, Trehalose, Maltose, Glucose, Sodium Hyaluronate, Citric Acid, Sodium Hydroxide, Disodium EDTA, Sodium Chloride, Steareth-20, Polysorbate 60, Caprylyl Glycol, Tribehenin, Coco-Glucoside, Pentylene Glycol, Hexylene Glycol, Urea, PEG-10 Rapeseed Sterol, Sodium Lactate, Sodium PCA, Phenoxyethanol, Potassium Sorbate, Fragrance/Parfum, Linalool, Limonene

Range:
Neuropeptide
Brand:
Perricone MD
Volume:
2.5 fl.oz / 75ml
Directions:

Massage onto cleansed face and neck in the evening using a gentle upward motion. Wait until fully absorbed, then follow with your favorite Perricone MD moisturizer if necessary.

Neuropeptide Night Cream

This ultra-rich night cream visibly and dramatically softens the appearance of deep lines and creases by deeply nourishing and hydrating.

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Twenty years of research have yielded our most advanced and comprehensive night treatment cream. This ultra-rich moisturizer works overnight to nourish skin with essential hydration and over time actively fights the appearance of deep lines and wrinkles, including nasolabial folds and marionette lines. Wake up to dramatically younger, smoother, healthier-looking skin.

What It Does

  • Addresses the 4-types of wrinkles: Fine Lines, Static Wrinkles, Dynamic Wrinkles and Gravitational Wrinkles.
  • Works with the body’s natural repair cycle to help rejuvenate the skin and deliver visible results night after night.
  • Visibly and dramatically softens the appearance of deep lines and creases.
  • Nourishes the skin with essential hydration.

What To Expect

Due to the science and compounds used in our products the feel and scent may vary.

Texture: Cream

Consistency: Luxurious & Rich

Scent: Natural

* This product is free from fish, milk, phthalates, sulfates, parabens, talc, and mineral oil. Cruelty-free and 100% vegan.

Consumer Results

93% agreed skin looked and felt more supple*
91% agreed skin looked and felt smoother*
83% agreed skin appeared rested, renewed and restored*
83% agreed they saw improvement in the appearance of surface fine lines*
78% agreed they saw improvement in the appearance of static and stubborn wrinkles*
*In a consumer study of 54 women after 28 days.

Neuropeptides: Uniting Surface Cells to Fight Wrinkles

owerful, protein-like building blocks offer the ultimate visible antidote to the look of wrinkles, sagging, dullness and discoloration. Neuropeptides support skin’s barrier and hydration via a unique chemical structure.

DMAE: Intensive Firming

Naturally produced by the human brain, DMAE helps visibly lift sagging skin over time. Easily and quickly absorbed, it visibly plumps skin to help support skin’s surface and protect against drying environmental aggressors.

Amino Acids: Build Stronger Skin

Organic compounds that make up over 20% of the human body, amino acids hydrate for firmer, smoother looking skin, help strengthen surface skin cells and have been used for a variety of skin benefits.

Ingredients:

Water/Aqua/Eau, Glycerin, Isononyl Isononanoate, Pentaerythrityl Tetraethylhexanoate, Cetearyl Alcohol, Butyrospermum Parkii (Shea) Butter, C12-20 Acid PEG-8 Ester, Dimethyl Isosorbide, C10-18 Triglycerides, Isodecyl Salicylate, Butylene Glycol, Hydroxyethyl Acrylate/Sodium Acryloyldimethyl Taurate Copolymer, Squalane, C12-15 Alkyl Benzoate, Dimethicone, Polymethyl Methacrylate, Dimethyl MEA, Acetyl Hexapeptide-8, Pentapeptide-18, Tetrapeptide-21, Dipeptide-2, Palmitoyl Tetrapeptide-7, Palmitoyl Hexapeptide-12, Tyrosine, Tocopheryl Acetate, Dipotassium Glycyrrhizate, Hesperidin Methyl Chalcone, Ceramide NG, Fructose, Allantoin, Trehalose, Maltose, Glucose, Sodium Hyaluronate, Citric Acid, Sodium Hydroxide, Disodium EDTA, Sodium Chloride, Steareth-20, Polysorbate 60, Caprylyl Glycol, Tribehenin, Coco-Glucoside, Pentylene Glycol, Hexylene Glycol, Urea, PEG-10 Rapeseed Sterol, Sodium Lactate, Sodium PCA, Phenoxyethanol, Potassium Sorbate, Fragrance/Parfum, Linalool, Limonene

Range:
Neuropeptide
Brand:
Perricone MD
Volume:
2.5 fl.oz / 75ml
Directions:

Massage onto cleansed face and neck in the evening using a gentle upward motion. Wait until fully absorbed, then follow with your favorite Perricone MD moisturizer if necessary.

Customer Reviews

Overall Rating : 4.38 / 5 (34 Reviews)
  • 27 5 star reviews
  • 0 4 star reviews
  • 2 3 star reviews
  • 3 2 star reviews
  • 2 1 star reviews
See all reviews
 

Top Customer Reviews

Where reviews refer to foods or cosmetic products, results may vary from person to person. Customer reviews are independent and do not represent the views of The Hut Group.

Totally Works!

I have ALL Perricone skincare! After I use up the subD serum, am staying with the C and Retinol and THIS! It literally has changed my face! In one application I saw a difference! So I ordered the day one too! It even works on my eyes! The BEST anti-aging cream I EVER used and I am 68! Its worth every nickel, especially with the new payment plans. And it takes such a small amount too. It works on my neck too! Great product, is a holy trail for sure!

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Totally Works!I

I switched skincare lines since I'm older now. Felt I needed something stronger at 68. Always wanted to try this line and thanks to Afterpay and Klarna, I have been able to. This is my last purchase for awhile as I have the two serums and another on the way, face finishing moisturizer, deep crease serum,sub d neck cream and more. This has totally changed my skin. I don't look forty, but my skin looks great, wrinkles are literally disappearing. My neck looks so much better. But it has taken about three months,which is fine with me. I didn't get these in a month. It took years. This cream just puts the finishing touch on it all. Thank you.

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My new nighttime ritual

My first experience with the neuropeptide products was the facial cream. I was so impressed after a few months that I added this to my skincare routine. My first tube separated, meaning I had to shake it vigorously before squirting any out or I would only get oil. When the tube was almost empty I cut it open and found the rich, emollient cream in the bottom of the tube. Knowing that Perricone products don’t have the greatest shelf life, I tried a second tube and it was perfect. You need to watch for this, Perricone! This is an expensive product; however, it’s a good one. I love what the combo of the day and night cream has done. My skin sensitivity is gone and my skin appears thicker. At age 64, with a thin face, I need all the help I can get to plump up my skin. I don’t need an additional nighttime moisturizer. This cream is enough.

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Great moisturizer!

This cream is the best moisturizer I found on the market. I’m 45 years old and need a cream that addresses dryness and fine lines. This cream is simply amazing. It gives me a beautiful glow as well. I use it in the morning under my makeup when I need extra hydration. I highly recommend it!

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I will definitely buy again

I love this moisturizer, I use it every night after I wash my face. It's got a thick texture but blends so well at the same time. My skin has definitely improved since I started using Perricone. I'm almost 50 and my skin is pretty healthy.

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I would totally buy this again!

I love this product! It's so rich, leaving my skin feeling plump and hydrated. It is pricier than my regular evening cream, but a little goes a long way. I used about a pea size and that's enough for my face and neck.

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Great night cream

I use this cream after a retinal application to prevent dryness.

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Be aware do not use this product

Nothing is good about it . I am in to my 5 th week from stopping using this cream and it feels like someone has poured acid over my face . It's bright red/ burning / itching / dry and tight And flaking. I am under the doctor at the moment for this bad reaction it hasn't got any better from start to finish . Well there is no finish it's still bad 5 weeks on .

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I wouldn't buy it again

I used this product 3 times and every time my skin Was itching ( specially on My chin and mouth corners) and red . It also went dry all over my chin and sides of mouth And dry patches here and there on my face . I do not have dry skin a bit oily to be fair but it is sensitive . My skin now feels tight and dryish. I will use it on my hands rather than waste my money throwing it away .

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Gave me a TERRIBLE breakout

I was looking for a moisturizing night cream without coconut oil or retinol for my dry, sensitive skin and to reduce the fine lines around my eyes, again without sensitizing retinol. This product seemed right up my alley. (The medium-chain triglycerides that are coconut derived have never given me issues in other products. Shea butter and dimethicone dont give me issues. None of the emulsifiers listed on the ingredients have been comedogenic for me though Ive never tried peptide products.). Within a handful of nights of recommended use (dime sized amount, thoroughly massaged into the skin after cleansing), my forehead broke out in over a dozen tiny, red blemishes. My skin is definitely moisturized, but looks like a pepperoni pizza. I havent had a breakout like this in over 10 years. I gave my rating 2 stars because even though it is very moisturizing and had already marginally reduced the lines around my eyes in just a few applications, those benefits are vastly outweighed by the blemishes. In the attached photo, you can see the new breakouts forming on my forehead. This was my first purchase of a Perricone MD product and I'm incredibly disappointed.

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