Meet Our Neuropeptide Collection: The New Era of Intelligent Skincare

When it comes to aging, knowledge is power — and science is beauty.

At Perricone MD, skincare has never been about chasing trends, it has always been about understanding biology and using cutting-edge science to support skin at every stage of life. Today, we proudly introduce the next evolution of an iconic franchise: our newly re-engineered Neuropeptide Collection.

This advanced collection represents the future of science-backed skincare, merging our heritage with next-generation biotechnology to deliver visible, measurable results. Built on decades of research and innovation, our Neuropeptide formulas address the most stubborn signs of aging by supporting communication between skin and brain — the brain-beauty connection Dr. Nicholas Perricone discovered long before it became a beauty buzzword.

This brain-beauty connection is rooted in the understanding that the skin is not an isolated organ. Skin is deeply connected to the nervous system, responding to signals that influence renewal, repair and resilience. Neuropeptides are short chains of amino acids that act as signaling molecules between the brain and skin to help restore unhealthy skin cells, supporting surface renewal and healthier-looking skin.

As Dr. Perricone explains: “Neuropeptides are a highly sophisticated proprietary technology that activates surface renewal to address problems of more mature skin.”

In other words, this is intelligent skincare elevated with the latest technologies for skin that deserves more.

The Evolution of Neuropeptides: Past, Present & Future

Long before peptides in skincare became mainstream, Dr. Perricone was the first to introduce them to topical skincare — a groundbreaking advancement that reshaped how we approach visible aging. While the industry focused on exfoliation and surface-level fixes, we explored how the skin responds to neurological signals, unlocking a deeper understanding of renewal and repair. This discovery laid the foundation for one of our most iconic franchises that’s trusted by dermatologists, estheticians and discerning consumers alike.

Over time, our Neuropeptide Collection has remained a cult favorite, celebrated for its transformative results and loyal following. From editorial acclaim to retail success stories, this franchise has earned its place as a cornerstone of Perricone MD’s philosophy of aging gracefully — particularly among women seeking answers for deep lines, sagging and loss of firmness.

Today, our reimagined collection represents the future of intelligent aging. Uniting the best of the original Neuropeptide line with our Essential Fx Acyl-Glutathione franchise, this elevated master collection has been upgraded with next-generation biotech innovation and refined for modern skin needs.

What Makes It Smart Skincare?

Unlike traditional peptides that act only on the skin’s surface, neuropeptides function at both the neurological level (influencing communication and cell signaling) and the cellular level (supporting visible improvements in firmness, tone, density and smoothness). This dual-action intelligence is what makes them truly smart skincare.

When it comes to communication, neuropeptides signal the skin to allow for the body’s natural release of what Dr. Perricone calls “The Beauty Molecule” (more on that here). In doing so, they help relax facial muscles and, in turn, soften expression lines for smoother, more luminous and youthful-looking skin.

Such genius skincare is not formulated overnight, of course. Our Neuropeptide Collection is backed by nearly 30 years of Dr. Perricone’s research. Powered by the latest advancements in neuropeptide technology combined with next-generation biotechnical ingredients, each formula is proven to target the most advanced concerns. At the heart of the collection are three unparalleled technologies:

Neuropeptides

These intelligent molecules help unite surface cells to visibly reduce wrinkle depth while restoring communication between skin and brain. As one of the most advanced peptides for mature skin, neuropeptides support a smoother, firmer, more resilient complexion.

Biomimetic Growth Factor Peptides

Designed to mimic skin’s natural growth factors, these peptides visibly support the look of natural collagen levels to visibly lift, firm and sculpt the skin.

Plant Stem Cells

Powerfully innovative plant stem cells support renewal by visibly increasing skin density and resilience, helping skin appear smoother, stronger and more youthful over time.

Who Is It Designed For? Those With Mature & Menopausal Skin

Our age-defying Neuropeptide Collection is specifically designed for women over 50 years old or those experiencing menopausal skin changes.

It’s around 50+ when skin turnover naturally slows. While younger skin renews itself approximately every 28 days, mature skin may take 50 to 90 days to complete the same cycle. The slower this process, the longer it takes for healthy new skin cells to reach the surface — and the longer it may take to see visible results without targeted support.

During menopause, collagen levels drop by up to 30% within five years, contributing to skin sagging, thinning and loss of elasticity. At the same time, natural neuropeptides and glutathione levels decline dramatically, accelerating visible aging and leaving skin vulnerable to dryness, crepiness and dullness.

That’s why our Neuropeptide Collection provides intelligent support for mature skin changes, offering a science-led approach for visibly firming skin and restoring density and resilience.

Meet the Heroes of the Collection

Each product in the Neuropeptide Collection is designed to address specific signs of aging while working synergistically for optimal results.

A modern icon reborn, this targeted serum smooths and plumps stubborn expression lines and deep wrinkles. Precision-engineered for areas that resist change, it exemplifies the power of science-backed skincare ingredients.

Specifically formulated for one of the most delicate areas of the face, this advanced serum targets drooping and sagging lids for a visibly lifted, awakened appearance.

Rich yet refined, this moisturizer deeply nourishes thin, depleted skin — restoring cushion, bounce and resilience while reinforcing the skin barrier.

This multitasking eye treatment brightens, firms and visibly reduces dark circles and puffiness — delivering revitalized, well-rested eyes with continued use.

The Art of Aging Gracefully: Skincare With Experience

The Neuropeptide Collection embodies the essence of the brain-beauty connection — uniting advanced science, sensorial luxury and visible results. It reflects our unwavering commitment to being doctor founded, research driven and grounded in efficacy rather than hype.

Your skin is intelligent. Give it the science it deserves.