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Highly-potent serum with a silky, luxurious texture absorbs quickly to smooth the look of even the most stubborn, deep-set lines, wrinkles and creases around the mouth, eyes, lips and forehead, including marionette lines, frown lines, smile lines and nasolabial folds. Over time, these engraved imperfections appear shallower and expression lines appear erased, as the vitamin F blend works to replenish skin’s moisture barrier and protect it from environmental aggressors.
What It Does
- Softens the look of facial lines from daily repetitive movements.
- Visibly improves etched creases making them appear more shallow.
- Minimizes the appearance of skin imperfections and imparts a beautiful radiance.
What To Expect
Due to the science and compounds used in our products the feel and scent may vary.
Texture: Serum
Consistency: Lightweight
Scent: Natural, aromatic rose
* This product is free from soy, nuts, gluten, fish, milk, corn, phthalates, sulfates, parabens, talc, and mineral oil. Cruelty-free.
After cleansing, massage onto face and neck using a gentle upward motion. Wait until fully absorbed and follow with your favorite Perricone MD moisturizer. Use morning and evening.
Consumer Results
Overall Skin Condition:
93% noticed skin looked renewed*
84% saw that skin looked more toned*
Advanced Claims:
89% noticed an improvement in lines and texture*
86% felt firmer, tighter skin*
86% saw an improvement in expression lines*
84% saw that wrinkles were smoothed*
83% noticed creases appeared shallower and forehead lines appeared smoother*
82% saw tighter-looking skin*
80% saw lines smoothed around the mouth and lips*
79% noticed engraved imperfections appeared shallower*
77% noticed that skin looked lifted*
74% felt that skin looked dramatically younger*
73% saw that deep-set wrinkles, including marionette lines and nasolabial folds were smoothed*
*In a consumer study of 102 women after 28 days
Acyl-Glutathione: The Master Antioxidant
Comprised of 3 amino acids, glutathione is the body’s main antioxidant and as part of a comprehensive skincare regimen can help to reduce the look of wrinkles and creases by replenishing fragile skin. Natural levels of this essential building block deplete over time, but topical application can help skin appear smoother and more youthful.
Vitamin F Blend: Ultimate Moisture Barrier Protection
Flax, chia and macadamia seed oils work over time to restore suppleness and create a healthy glow by intensely moisturizing and improving skin’s moisture barrier. Essential, yet not naturally found in the human body.
Ingredients:
Water/Aqua/Eau, Propanediol, Squalane, Hydrogenated Polyisobutene, S-Palmitoylglutathione, Dimethicone, Glycerin, Macadamia Ternifolia Seed Oil, Xylitylglucoside, Tetrahexyldecyl Ascorbate, Dimethyl MEA, Palmitoyl Tripeptide-5, Acetyl Hexapeptide-8, Anhydroxylitol, Lactic Acid, Xylitol, Xanthan Gum, Linum Usitatissimum (Linseed) Seed Oil, Salvia Hispanica Seed Oil, Tocopherol, Ethylhexylglycerin, Magnesium Aspartate, Zinc Gluconate, Alaria Esculenta Extract, Glucose, Sodium Hyaluronate, Copper Gluconate, Tetradecyl Aminobutyroylvalylaminobutyric Urea Trifluoroacetate, Palmitoyl Dipeptide-5 Diaminobutyroyl Hydroxythreonine, Helianthus Annuus (Sunflower) Seed Oil, Rosmarinus Officinalis (Rosemary) Leaf Extract, Tetrasodium Glutamate Diacetate, Magnesium Chloride, Caprylic/Capric Triglyceride, Acrylates/C10-30 Alkyl Acrylate Crosspolymer, Caprylyl/Capryl Glucoside, Caprylyl Glycol, Potassium Sorbate, Phenoxyethanol, Fragrance/Parfum, Citronellol, Hydroxycitronellal, Limonene, Linalool
- Essential Fx Acyl-Glutathione
- Perricone MD
- 1 fl.oz / 30ml
Essential Fx Acyl-Glutathione Deep Crease Serum
Highly-potent serum to improve the appearance of deep creases, marionette and lip lines.
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$179.00
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4 instalments of $44.75 with Klarna Learn more
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4 installments of $44.75 with afterpay Learn more
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4 installments of $44.75 with zip Learn more
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Highly-potent serum with a silky, luxurious texture absorbs quickly to smooth the look of even the most stubborn, deep-set lines, wrinkles and creases around the mouth, eyes, lips and forehead, including marionette lines, frown lines, smile lines and nasolabial folds. Over time, these engraved imperfections appear shallower and expression lines appear erased, as the vitamin F blend works to replenish skin’s moisture barrier and protect it from environmental aggressors.
What It Does
- Softens the look of facial lines from daily repetitive movements.
- Visibly improves etched creases making them appear more shallow.
- Minimizes the appearance of skin imperfections and imparts a beautiful radiance.
What To Expect
Due to the science and compounds used in our products the feel and scent may vary.
Texture: Serum
Consistency: Lightweight
Scent: Natural, aromatic rose
* This product is free from soy, nuts, gluten, fish, milk, corn, phthalates, sulfates, parabens, talc, and mineral oil. Cruelty-free.
After cleansing, massage onto face and neck using a gentle upward motion. Wait until fully absorbed and follow with your favorite Perricone MD moisturizer. Use morning and evening.
Consumer Results
Overall Skin Condition:
93% noticed skin looked renewed*
84% saw that skin looked more toned*
Advanced Claims:
89% noticed an improvement in lines and texture*
86% felt firmer, tighter skin*
86% saw an improvement in expression lines*
84% saw that wrinkles were smoothed*
83% noticed creases appeared shallower and forehead lines appeared smoother*
82% saw tighter-looking skin*
80% saw lines smoothed around the mouth and lips*
79% noticed engraved imperfections appeared shallower*
77% noticed that skin looked lifted*
74% felt that skin looked dramatically younger*
73% saw that deep-set wrinkles, including marionette lines and nasolabial folds were smoothed*
*In a consumer study of 102 women after 28 days
Acyl-Glutathione: The Master Antioxidant
Comprised of 3 amino acids, glutathione is the body’s main antioxidant and as part of a comprehensive skincare regimen can help to reduce the look of wrinkles and creases by replenishing fragile skin. Natural levels of this essential building block deplete over time, but topical application can help skin appear smoother and more youthful.
Vitamin F Blend: Ultimate Moisture Barrier Protection
Flax, chia and macadamia seed oils work over time to restore suppleness and create a healthy glow by intensely moisturizing and improving skin’s moisture barrier. Essential, yet not naturally found in the human body.
Ingredients:
Water/Aqua/Eau, Propanediol, Squalane, Hydrogenated Polyisobutene, S-Palmitoylglutathione, Dimethicone, Glycerin, Macadamia Ternifolia Seed Oil, Xylitylglucoside, Tetrahexyldecyl Ascorbate, Dimethyl MEA, Palmitoyl Tripeptide-5, Acetyl Hexapeptide-8, Anhydroxylitol, Lactic Acid, Xylitol, Xanthan Gum, Linum Usitatissimum (Linseed) Seed Oil, Salvia Hispanica Seed Oil, Tocopherol, Ethylhexylglycerin, Magnesium Aspartate, Zinc Gluconate, Alaria Esculenta Extract, Glucose, Sodium Hyaluronate, Copper Gluconate, Tetradecyl Aminobutyroylvalylaminobutyric Urea Trifluoroacetate, Palmitoyl Dipeptide-5 Diaminobutyroyl Hydroxythreonine, Helianthus Annuus (Sunflower) Seed Oil, Rosmarinus Officinalis (Rosemary) Leaf Extract, Tetrasodium Glutamate Diacetate, Magnesium Chloride, Caprylic/Capric Triglyceride, Acrylates/C10-30 Alkyl Acrylate Crosspolymer, Caprylyl/Capryl Glucoside, Caprylyl Glycol, Potassium Sorbate, Phenoxyethanol, Fragrance/Parfum, Citronellol, Hydroxycitronellal, Limonene, Linalool
- Essential Fx Acyl-Glutathione
- Perricone MD
- 1 fl.oz / 30ml
Customer Reviews
Top Customer Reviews
Where reviews refer to foods or cosmetic products, results may vary from person to person. Customer reviews are independent and do not represent the views of The Hut Group.
how wonderful
I am skeptical of many facial fixes. Â I am amazed how this serum altered the depth of the lines around my lips . Â Bravo!!!!
Report this reviewDeep crease serum
What a great product!! As are all Pericone products. I noticed right away on my forehead. Those nasty lines that crinkle up when you show expressions. You know what I mean lol. Adds 5 years just by laughing haha. A little goes a long way. I now have a botox looking forehead. Nice & smooth. I only have to use a tiny, & I mean a tiny bit. Absorbs relatively fast. Use around mouth and that good old line in the crease of neck. Use sparingly, along with other Pericone products and you'll look 10 years younger in only a couple weeks. But you do see results within a week. Another Pericone favorite!!
Report this reviewLove this product
Works almost instantly. I was very surprised how the fine lines were remarkably less pronounced upon application. I highly recommend the product to anyone who wish to reduce fine lines & wrinkles.
Report this reviewYes. This product works
I found this product a few years ago and used it to great effect. Then it went out of stock for a long time and of course my creases deepened again. It's back! Buy it. For years I've had deep crease between my eyebrows(age 70).This product definitely softens the deep creases between my eyebrows and around my mouth.Â
Report this reviewYouth in a Bottle
Run don’t walk.  This stuff is amazing and it works fast. I had very deep creases on my forehead. I won’t mention any names, but I had tried several high end products that did not work.  This product erased by finer creases with in three days and has significantly diminished the crater or a crease on my forehead. Very happy. Cannot live without!! Also the results don’t just disappear when you stop using the product.Â
Report this reviewLiquid Botox
I’ve been using this serum for over 2 years…. Someone introduced me to this serum that used to get Botox…. She described this as liquid Botox and she sure was not wrong… I’m 43 years old and no wrinkles what so ever! Love love loveÂ
Report this reviewGreat product
I do love this serum. It definitely makes a difference; one of the only products that helps with marionette lines. It is a bit too expensive for me. I ordered it when I got a good discount ( 1/2 off). I don't think I'll be ordering it again until that discount as available again because I cannot afford it.
Report this reviewReliable Product
Perricone MD always provides Great products that are Very Reliable. The Deep Crease Serum has worked wonders on what used to be "deep creases" on my face! The key is to use it Daily! Works Great!
Report this reviewMagic
I am so impressed with this deep crease serum, for me, it exceeded my hopes and expectations. I have been forming fine lines across my forehead from repetitive motions and stress!) and have been watching them grow deeper and spread further over time. I have tried other products with mild results, but this is the first serum that I have ever used where I can say that I actually see a significant difference in my skin. For the past month I have incorporated this serum every night as part of my PM skincare routine and the lines are not only fading, but some have actually disappeared... this stuff is magic! At first I only was using two drops on my forehead, but now I also use a drop on my smile lines and across the horizontal lines on my neck. I am so incredibly pleased with my results so far, I look forward to continued improvement of my skin with daily use. The price may be steep, but you truly use so little at a time and the results are noticeable and very real.
Most Helpful Reviewer
Small reduction
Used over the past month, twice a day. Small reduction in my major forehead creases.
Report this review