High Potency Collection

High Potency. This collection address lines, wrinkles, uneven texture and tone, as well as loss of firmness with the full force of out signature sciences.

SHOP ALL SHOP REGIMENS SHOP TRIPLE RETINOL

RETINOL TRIFECTA

High Potency Triple Retinol Renewal Serum

This day and night serum accelerates skin renewal with less sensitivity to deliver the look of collagen-rich, firmer skin. Works together with antioxidant powerhouse coenzyme Q10 and naturally-derived betacarotene (vitamin A) to visibly diminish uneven texture and dullness for a more even, radiant complexion.

High Potency Triple Retinol Renewal Eye Serum

A powerful eye serum accelerates skin renewal with less sensitivity to reduce the look of under-eye puffiness and uneven texture for a firmer, smoother appearance. Works together with antioxidant powerhouse coenzyme Q10 and naturally-derived beta-carotene (vitamin A) to visibly brighten and minimize dark circles and darkness for a more open, awakened look.

High Potency Retinol Recovery Overnight Moisturizer

This rich, ultra-nourishing moisturizer works overnight with three forms of retinol to help support during the skin's natural recovery and renewal process by promoting a visible reduction in lines and wrinkles. Delivers intense hydration to thoroughly replenish and protect the skin's moisture barrier for a firmer, smoother, more rested complexion.

THE SCIENCE OF HIGH POTENCY

Image of High Potency Jar. Tighten and enlarges pores. Diminishes fine lines & wrinkles. Refines and smoothes uneven texture.

TARGETED SOLUTIONS FOR LINES, WRINKLES & ENLARGED PORES

Formulated with high concentrations of Perricone MD's signature sciences, the High Potency Collection provides targeted solutions for more youthful, healthier-looking skin. Each formula is designed to help visibly tighten pores and visibly minimize the length, depth and width of fine lines and wrinkles using some of our most advanced age-defying ingredients.

Image of High potency ingredients. Alpha-Lipoic Acid. Reduces the appearance of lines, wrinkles and enlarged pores over time. DMAE. Visibly plumps skin to help support skin's surface and protect against drying environmental aggressors.

UNDERSTANDING THE SCIENCES

Featuring Alpha-Lipoic Acid (ALA) and DMAE.
ALA, nature’s most powerful antioxidant, is a fatty acid found in every cell in the human body that penetrates skin’s surface to help reduce the appearance of lines, wrinkles and enlarged pores over time.
DMAE, naturally produced by the human brain, helps visibly lift sagging skin over time. Easily and quickly absorbed, it helps visibly plump skin to support skin’s surface structure and protect against drying environmental aggressors

Image of High potency Intensive Trio Box set.

THE INTENSIVE TRIO STARTER COLLECTION

The perfect way to try the High Potency Collection, the Intensive Trio is designed for skin that requires more targeted solutions. Formulated with Alpha-Lipoic Acid, DMAE and polyamine growth factor to reduce the appearance of fine lines and wrinkles and to smooth uneven skin texture.

SHOP THE HIGH POTENCY COLLECTION

HIGH POTENCY RETINOL RECOVERY OVERNIGHT MOISTURIZER

FOR FURTHER READING

RETINOL MYTHS, DEBUNKED: 5 THINGS WE BET YOU DIDN’T KNOW ABOUT RETINOL

As vitamin A-derived retinol continues to rise in popularity, so do its misconceptions. This is largely, in part, because of countless skin-fluencers spreading misinformation under the guise of it being expert advice. So, we’re taking some of the retinol myths we frequently see circulating and debunking each one of them.

JENNIE GARTH’S 2025 SKINCARE SECRET IS OUT: THESE ARE HER NEW HOLY GRAIL PRODUCTS

Jennie Garth prioritizes self-care year-round. Her "I Choose Me" mantra reflects her commitment to personal well-being, and she partners with Perricone MD, a brand she's trusted for years, to achieve healthy aging and feel confident in her own skin.

HOW TO REAP THE BENEFITS OF RETINOL WITHOUT THE IRRITATION

Retinoids, discovered in 1909, have been used in dermatology since the 1950s. Initially for acne, they now combat aging. While potent forms can irritate, milder options like retinol offer significant benefits. Choosing the right retinol formula is crucial for effective and safe results.