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What Really Causes Acne?
Excess oil, acne-causing bacteria and inflammation are the culprits, and you need to treat all three.
Unlike most other acne treatment systems on the market, Perricone MD Acne Relief selectively targets and gently treats all three causes of acne - excess oil, acne-causing bacteria and inflammation. Many other brands rely on harsh chemicals that just kill all bacteria, or aggressively strip your skin of necessary hydration, which can upset skin’s natural microbiome and lead to irritation and dryness. Rather than wash away all oil and bacteria, Acne Relief is designed to work symbiotically with skin’s microbiome to remove excess oil while simultaneously depositing hydrators that won’t dry skin out.
Step 1: Day & Night Acne Relief Gentle & Soothing Cleanser
Lather a quarter-sized amount in hands & gently massage onto damp skin. Rinse thoroughly with warm water. For best results, follow with ACNE RELIEF Calming Treatment & Hydrator in the morning & ACNE RELIEF Retinol Treatment & Moisturizer in the evening.
Step 2: Day Acne Relief Calming Treatment & Hydrator
Shake well. Apply a thin, even layer to skin in the morning. For best results, use after cleansing with ACNE RELIEF Gentle & Soothing Cleanser.
Step 2: Night Acne Relief Retinol Treatment & Moisturizer
Shake well. Apply a thin, even layer to skin in the evening. For best results, use after cleansing with ACNE RELIEF Gentle & Soothing Cleanser.
Our Prebiotic Approach
Understand the science and benefits behind creating a healthy microbiome and balanced skin.
The patent-pending science behind Acne Relief is our prebiotic approach, a system that adapts to your skin’s unique microbiome to target troublesome acne. Using naturally occurring prebiotics, Acne Relief helps your skin safely and gently fight back against acne without disrupting its natural balance. The result? An effective defense against acne-causing bacteria that promotes a clear, blemish-free complexion.
Below are some of the key ingredients in Acne Relief behind our prebiotic approach:
Sucrose: Exfoliate & Support a Healthy Skin Biome
Milled to an ultra-fine sugar, this mild exfoliant helps unclog pores and remove excess dirt and oil without over-drying or stripping skin. Sucrose helps support a healthy skin biome by encouraging good bacteria and rinses off quickly and easily, making it ideal for gentle yet effective cleansing.
Citrulline: Fight Irritation & Visibly Reduce Redness
First discovered in watermelon, this alpha-amino acid visibly calms skin for a clearer, more even-looking complexion. Nourishing and soothing, it is an ideal way to counteract irritation.
Lactic & Succinic Acids: Attack Acne-Causing Bacteria
These short-chain fatty acids help quickly shrink blemishes by working alongside salicylic acid to attack acne-causing bacteria for a healthier skin microbiome. They also provide gentle yet effective exfoliation for smoother, more even-looking skin.
Niacinamide: Gentle Skin-Clearing Multi-Tasker
Also known as vitamin B3 and found in foods such as tomatoes, this skin-clearing powerhouse helps to gently and visibly erase imperfections, unclog oily pores and minimize uneven skin tone that can be left behind after breakouts by improving skin’s moisture barrier. Niacinamide is one of the essential vitamins skin needs to maintain a youthful look.
Squalane: Hydrate & Nourish
Found naturally in the human body and derived from olive oil, squalane hydrates without making skin look or feel greasy. This lightweight hydration is ideal for oil and acne-prone skin as it helps maintain optimal hydration without leaving skin feeling greasy and clogged.
Salicylic Acid: Pore-Minimizing, Anti-Acne Exfoliation
A beta-hydroxy acid (BHA), salicylic acid is a non-prescription treatment for acne and oil-prone skin. It quickly and effectively exfoliates and removes dead skin which can clog pores and cause breakouts. Because it is oil-soluble, salicylic acid is easily absorbed into pores for targeted, more effective results.
Retinol: Exfoliate for Clearer Skin & Accelerated Rejuvenation
This ultra-powerful, non-prescription vitamin A derivative helps prevent breakouts by unclogging pores and accelerating surface skin exfoliation and renewal. Retinol is the #1 dermatologist recommended, non-prescription skin-aging solution.
Acne Relief Gentle & Soothing Cleanser
Glycerin, Sodium Cocoyl Isethionate, Ethylhexyl Palmitate, Silica Cetyl Silylate, Sucrose, Squalane, Polyacrylamide, Water/ Aqua/Eau, Caprylyl Glycol, C13-14 Isoparaffin, Laureth-7, Phenoxyethanol
Acne Relief Calming Treatment & Hydrator
Water/Aqua/Eau, SD Alcohol 40-B, Glycerin, C12-15 Alkyl Lactate, PVP, Dimethicone, Polysorbate 20, Citrulline, Squalane, Lactic Acid, Succinic Acid, Polyacrylamide, Dimethicone/Vinyl Dimethicone Crosspolymer, C13-14 Isoparaffin, Laureth-7, Phenoxyethanol, Sodium Benzoate, Potassium Sorbate
Acne Relief Retinol Treatment & Moisturizer
Water/Aqua/Eau, SD Alcohol 40-B, Glycerin, Dicaprylyl Ether, Niacinamide, Citrulline, Arginine, Methyl Gluceth-20, Cetearyl Alcohol, Carbomer, Xanthan Gum, Tocopheryl Acetate, Retinol, Citric Acid, Sodium Hydroxide, Disodium EDTA, PEG-20 Methyl Glucose Sesquistearate, PEG-100 Stearate, Glyceryl Stearate, Methyl Glucose Sesquistearate, Polysorbate 20, Phenoxyethanol, Sodium Benzoate, Potassium Sorbate
- Acne Relief
- Perricone MD
- 2 x 2 fl.oz / 6 fl.oz - 2 x 59ml / 177ml
Acne Relief Prebiotic Acne Therapy 90-Day Regimen
A simple, two-step skincare system that works with your skin’s natural microbiome to target and safely yet effectively treat three causes of acne: excess oil, acne-causing bacteria and inflammation.
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Value $125.00
$89.00
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4 instalments of $22.25 with Klarna Learn more
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4 installments of $22.25 with afterpay Learn more
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4 installments of $22.25 with zip Learn more
SAVE UP TO 50% ON ACNE RELIEF WITH CODE: ACNE50
Offer valid until 06/30/2023 11:59 p.m. Pacific Time or while supplies last. Offer cannot be combined with other discounts or applied to past purchases. Offers and promotions may be subject to additional terms and conditions. Exclusions may apply.
Offer valid until 06/30/2023 11:59 p.m. Pacific Time or while supplies last. Offer cannot be combined with other discounts or applied to past purchases. Offers and promotions may be subject to additional terms and conditions. Exclusions may apply.
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What Really Causes Acne?
Excess oil, acne-causing bacteria and inflammation are the culprits, and you need to treat all three.
Unlike most other acne treatment systems on the market, Perricone MD Acne Relief selectively targets and gently treats all three causes of acne - excess oil, acne-causing bacteria and inflammation. Many other brands rely on harsh chemicals that just kill all bacteria, or aggressively strip your skin of necessary hydration, which can upset skin’s natural microbiome and lead to irritation and dryness. Rather than wash away all oil and bacteria, Acne Relief is designed to work symbiotically with skin’s microbiome to remove excess oil while simultaneously depositing hydrators that won’t dry skin out.
Step 1: Day & Night Acne Relief Gentle & Soothing Cleanser
Lather a quarter-sized amount in hands & gently massage onto damp skin. Rinse thoroughly with warm water. For best results, follow with ACNE RELIEF Calming Treatment & Hydrator in the morning & ACNE RELIEF Retinol Treatment & Moisturizer in the evening.
Step 2: Day Acne Relief Calming Treatment & Hydrator
Shake well. Apply a thin, even layer to skin in the morning. For best results, use after cleansing with ACNE RELIEF Gentle & Soothing Cleanser.
Step 2: Night Acne Relief Retinol Treatment & Moisturizer
Shake well. Apply a thin, even layer to skin in the evening. For best results, use after cleansing with ACNE RELIEF Gentle & Soothing Cleanser.
Our Prebiotic Approach
Understand the science and benefits behind creating a healthy microbiome and balanced skin.
The patent-pending science behind Acne Relief is our prebiotic approach, a system that adapts to your skin’s unique microbiome to target troublesome acne. Using naturally occurring prebiotics, Acne Relief helps your skin safely and gently fight back against acne without disrupting its natural balance. The result? An effective defense against acne-causing bacteria that promotes a clear, blemish-free complexion.
Below are some of the key ingredients in Acne Relief behind our prebiotic approach:
Sucrose: Exfoliate & Support a Healthy Skin Biome
Milled to an ultra-fine sugar, this mild exfoliant helps unclog pores and remove excess dirt and oil without over-drying or stripping skin. Sucrose helps support a healthy skin biome by encouraging good bacteria and rinses off quickly and easily, making it ideal for gentle yet effective cleansing.
Citrulline: Fight Irritation & Visibly Reduce Redness
First discovered in watermelon, this alpha-amino acid visibly calms skin for a clearer, more even-looking complexion. Nourishing and soothing, it is an ideal way to counteract irritation.
Lactic & Succinic Acids: Attack Acne-Causing Bacteria
These short-chain fatty acids help quickly shrink blemishes by working alongside salicylic acid to attack acne-causing bacteria for a healthier skin microbiome. They also provide gentle yet effective exfoliation for smoother, more even-looking skin.
Niacinamide: Gentle Skin-Clearing Multi-Tasker
Also known as vitamin B3 and found in foods such as tomatoes, this skin-clearing powerhouse helps to gently and visibly erase imperfections, unclog oily pores and minimize uneven skin tone that can be left behind after breakouts by improving skin’s moisture barrier. Niacinamide is one of the essential vitamins skin needs to maintain a youthful look.
Squalane: Hydrate & Nourish
Found naturally in the human body and derived from olive oil, squalane hydrates without making skin look or feel greasy. This lightweight hydration is ideal for oil and acne-prone skin as it helps maintain optimal hydration without leaving skin feeling greasy and clogged.
Salicylic Acid: Pore-Minimizing, Anti-Acne Exfoliation
A beta-hydroxy acid (BHA), salicylic acid is a non-prescription treatment for acne and oil-prone skin. It quickly and effectively exfoliates and removes dead skin which can clog pores and cause breakouts. Because it is oil-soluble, salicylic acid is easily absorbed into pores for targeted, more effective results.
Retinol: Exfoliate for Clearer Skin & Accelerated Rejuvenation
This ultra-powerful, non-prescription vitamin A derivative helps prevent breakouts by unclogging pores and accelerating surface skin exfoliation and renewal. Retinol is the #1 dermatologist recommended, non-prescription skin-aging solution.
Acne Relief Gentle & Soothing Cleanser
Glycerin, Sodium Cocoyl Isethionate, Ethylhexyl Palmitate, Silica Cetyl Silylate, Sucrose, Squalane, Polyacrylamide, Water/ Aqua/Eau, Caprylyl Glycol, C13-14 Isoparaffin, Laureth-7, Phenoxyethanol
Acne Relief Calming Treatment & Hydrator
Water/Aqua/Eau, SD Alcohol 40-B, Glycerin, C12-15 Alkyl Lactate, PVP, Dimethicone, Polysorbate 20, Citrulline, Squalane, Lactic Acid, Succinic Acid, Polyacrylamide, Dimethicone/Vinyl Dimethicone Crosspolymer, C13-14 Isoparaffin, Laureth-7, Phenoxyethanol, Sodium Benzoate, Potassium Sorbate
Acne Relief Retinol Treatment & Moisturizer
Water/Aqua/Eau, SD Alcohol 40-B, Glycerin, Dicaprylyl Ether, Niacinamide, Citrulline, Arginine, Methyl Gluceth-20, Cetearyl Alcohol, Carbomer, Xanthan Gum, Tocopheryl Acetate, Retinol, Citric Acid, Sodium Hydroxide, Disodium EDTA, PEG-20 Methyl Glucose Sesquistearate, PEG-100 Stearate, Glyceryl Stearate, Methyl Glucose Sesquistearate, Polysorbate 20, Phenoxyethanol, Sodium Benzoate, Potassium Sorbate
- Acne Relief
- Perricone MD
- 2 x 2 fl.oz / 6 fl.oz - 2 x 59ml / 177ml
Customer Reviews
Top Customer Reviews
Where reviews refer to foods or cosmetic products, results may vary from person to person. Customer reviews are independent and do not represent the views of The Hut Group.
Recommend highly!
My son had a pimple so terrible that he is in adolescence. I sent these sets to him, he used them, and his annoyed acne was calm. I repeatedly sent this set. Thank you! He is enjoying his school life.
Report this reviewI'm in love!
This is the ONLY ANCE TREATMENT that WORKS for me. BUY IT! I'm not joking. I'm 24 years old. Ever since I was 13 I've had the worst acne ever. I tried everything trust me. I thought I was hopeless until one day I walked into ulta with my mom in tears because I my acne got even worse. This time I had millions large and small pimples all over my face not leaving a single spot clear. We found Pericone MD at our local ulta and my mom convinced me to try it since I've never tried it before. It worked! I know this review seems to exaggerated, but it's not. This acne line saved me. Keep in mind I have sensitive skin. Honestly I found these produces last year in May and I'm never giving it up.
Report this reviewclean skin Say Thanks Perricone!
I take this set all the time and alternate it with Pericon anti-aging products, because my problem skin is cleaned very well by this line
Report this reviewDidn’t think I needed this
I got a free sample of this collection, and I was very impressed by the way my skin reacted to it. Since I am in my early 30s and don’t have acne the way I used to in my teens, I thought I did not need acne treatments. Though I do have some mild acne on my jawline, mild enough to ignore but once I tried using this combination, my skin reacted very positively to it, and that mild acne has begun to fade even on the first week. I’m impressed. However, I don’t like the consistency of the face wash. It feels very chill like but that’s a minor inconvenience. Besides the fact that my skin is looking fabulous.
Report this reviewWorking set
I have bought this set not the first time it really works. Fades red spots over time and soothes the skin
Report this reviewPeritoneal MD
This Face product has help my Teenager now young Adult Daughter Tremendously I'm glad I scanned the QR code on Good Morning America Steals and Deals .
Report this reviewI like this product
I have occasional breakouts with cystic looking acne. I use this product and I am satisfied with it as it seems to be keeping acne away. My problem is that I have been using the acne products morning and night and would like to use Perricone products that I have been using for years now that the acne seems OK. Do I stop using the acne system or combine the products that I have used for years with the acne products?? I have been using Perricone face creams and serums for years and don't know how to use the products now.
Report this reviewI have more breakouts after using!
This is the absolute worst product I’ve ever used on my face. I never had breakouts as a teen, but developed cystic acne and problem skin in my 30s. Now in my early 40s, I am in an all-out war with my skin. I suffer from oily, porous, sensitive skin that will take forever to clear up of a major breakout, only to breakout all over again. So far the only products that I saw any real improvement w/ contained benzoyl peroxide, but that over dries my skin, causing a whole new set of problems. After watching the slick marketing video on Perricone MD’s Acne Relief System, I thought I’d give it a try b/c they specifically mention ingredients that aren’t harsh or abrasive to your skin. Well… I should have read the small print (i.e. the INGREDIENTS list) because that video fails to mention the ACTIVE INGREDIENT in all three of these products is Salicylic Acid! And there is nothing Calm or Soothing about Salicylic Acid!  Within one week of using these products as recommended my breakouts were Bigger, Redder and Angrier looking - not to mention more painful than I could bear. It hurt to even touch my face. But, I kept on using thinking this was just the product working and it would ease up once my skin got used to it. Unfortunately, that was not the case for me. I got more breakouts; big, red, angry ones and the skin on my face was always inflamed  and painful to the touch. After nearly 3 weeks I finally realized the product wasn’t working and stopped using it and my skin instantly thanked me. Let this be a warning to anyone who has sensitive skin: DO NOT USE IF YOU ARE SENSITIVE TO HARSH CHEMICALS! I went back to my all-natural face wash scrub from Dirty Works and my skin healed w/in 2 weeks - all except a massive crater/scar on one cheek that was the worst of my breakouts from using this product. It’s taking much longer to heal and will certainly leave me with a very large scar on my cheek. So thanks for that Perricone. Not only am I out the $$, but I’m literally scarred for life.
Report this reviewgreat for kids and and teens
We´ve been using this products for over a month and they really help
Report this reviewAmazing
My face has never been so clear and healthy. I could see the difference when I don't use it regularly.
Report this review
