SAVE UP TO 40% WITH THE MEMORIAL DAY SALE AND GET A GIFT WITH PURCHASE - SPEND UP TO $250 AND RECEIVE A DOZEN DELIGHTS (VALUE $415). USE CODE: SUMMER22 - | SHOP NOW ▶︎

What Really Causes Acne?

Excess oil, acne-causing bacteria and inflammation are the culprits, and you need to treat all three.

Unlike most other acne treatment systems on the market, Perricone MD Acne Relief selectively targets and gently treats all three causes of acne - excess oil, acne-causing bacteria and inflammation. Many other brands rely on harsh chemicals that just kill all bacteria, or aggressively strip your skin of necessary hydration, which can upset skin’s natural microbiome and lead to irritation and dryness.  Rather than wash away all oil and bacteria, Acne Relief is designed to work symbiotically with skin’s microbiome to remove excess oil while simultaneously depositing hydrators that won’t dry skin out. 

Our Prebiotic Approach

Understand the science and benefits behind creating a healthy microbiome and balanced skin.

The patent-pending science behind Acne Relief is our prebiotic approach, a system that adapts to your skin’s unique microbiome to target troublesome acne. Using naturally occurring prebiotics, Acne Relief helps your skin safely and gently fight back against acne without disrupting its natural balance. The result? An effective defense against acne-causing bacteria that promotes a clear, blemish-free complexion.

Below are some of the key ingredients in Acne Relief behind our prebiotic approach:

Sucrose: Exfoliate & Support a Healthy Skin Biome

Milled to an ultra-fine sugar, this mild exfoliant helps unclog pores and remove excess dirt and oil without over-drying or stripping skin. Sucrose helps support a healthy skin biome by encouraging good bacteria and rinses off quickly and easily, making it ideal for gentle yet effective cleansing.

Citrulline: Fight Irritation & Visibly Reduce Redness

First discovered in watermelon, this alpha-amino acid visibly calms skin for a clearer, more even-looking complexion. Nourishing and soothing, it is an ideal way to counteract irritation.

Lactic & Succinic Acids: Attack Acne-Causing Bacteria

These short-chain fatty acids help quickly shrink blemishes by working alongside salicylic acid to attack acne-causing bacteria for a healthier skin microbiome. They also provide gentle yet effective exfoliation for smoother, more even-looking skin.

Niacinamide: Gentle Skin-Clearing Multi-Tasker

Also known as vitamin B3 and found in foods such as tomatoes, this skin-clearing powerhouse helps to gently and visibly erase imperfections, unclog oily pores and minimize uneven skin tone that can be left behind after breakouts by improving skin’s moisture barrier. Niacinamide is one of the essential vitamins skin needs to maintain a youthful look.

Squalane: Hydrate & Nourish

Found naturally in the human body and derived from olive oil, squalane hydrates without making skin look or feel greasy. This lightweight hydration is ideal for oil and acne-prone skin as it helps maintain optimal hydration without leaving skin feeling greasy and clogged.

Salicylic Acid: Pore-Minimizing, Anti-Acne Exfoliation

A beta-hydroxy acid (BHA), salicylic acid is a non-prescription treatment for acne and oil-prone skin. It quickly and effectively exfoliates and removes dead skin which can clog pores and cause breakouts. Because it is oil-soluble, salicylic acid is easily absorbed into pores for targeted, more effective results.

Retinol: Exfoliate for Clearer Skin & Accelerated Rejuvenation

This ultra-powerful, non-prescription vitamin A derivative helps prevent breakouts by unclogging pores and accelerating surface skin exfoliation and renewal. Retinol is the #1 dermatologist recommended, non-prescription skin-aging solution.

Acne Relief Gentle & Soothing Cleanser

Glycerin, Sodium Cocoyl Isethionate, Ethylhexyl Palmitate, Silica Cetyl Silylate, Sucrose, Squalane, Polyacrylamide, Water/ Aqua/Eau, Caprylyl Glycol, C13-14 Isoparaffin, Laureth-7, Phenoxyethanol

Acne Relief Calming Treatment & Hydrator

Water/Aqua/Eau, SD Alcohol 40-B, Glycerin, C12-15 Alkyl Lactate, PVP, Dimethicone, Polysorbate 20, Citrulline, Squalane, Lactic Acid, Succinic Acid, Polyacrylamide, Dimethicone/Vinyl Dimethicone Crosspolymer, C13-14 Isoparaffin, Laureth-7, Phenoxyethanol, Sodium Benzoate, Potassium Sorbate

Acne Relief Retinol Treatment & Moisturizer

Water/Aqua/Eau, SD Alcohol 40-B, Glycerin, Dicaprylyl Ether, Niacinamide, Citrulline, Arginine, Methyl Gluceth-20, Cetearyl Alcohol, Carbomer, Xanthan Gum, Tocopheryl Acetate, Retinol, Citric Acid, Sodium Hydroxide, Disodium EDTA, PEG-20 Methyl Glucose Sesquistearate, PEG-100 Stearate, Glyceryl Stearate, Methyl Glucose Sesquistearate, Polysorbate 20, Phenoxyethanol, Sodium Benzoate, Potassium Sorbate

Range:
Acne Relief
Brand:
Perricone MD
Volume:
2 x 2 fl.oz / 6 fl.oz - 2 x 59ml / 177ml
Directions:

Step 1: Day & Night Acne Relief Gentle & Soothing Cleanser

Lather a quarter-sized amount in hands & gently massage onto damp skin. Rinse thoroughly with warm water. For best results, follow with ACNE RELIEF Calming Treatment & Hydrator in the morning & ACNE RELIEF Retinol Treatment & Moisturizer in the evening.

Step 2: Day  Acne Relief Calming Treatment & Hydrator

Shake well. Apply a thin, even layer to skin in the morning. For best results, use after cleansing with ACNE RELIEF Gentle & Soothing Cleanser.

Step 2: Night Acne Relief Retinol Treatment & Moisturizer

Shake well. Apply a thin, even layer to skin in the evening. For best results, use after cleansing with ACNE RELIEF Gentle & Soothing Cleanser.

Acne Relief Prebiotic Acne Therapy 90-Day Regimen

A simple, two-step skincare system that works with your skin’s natural microbiome to target and safely yet effectively treat three causes of acne: excess oil, acne-causing bacteria and inflammation.

Purchase options
Auto Replenishment Benefits
  • Free delivery
  • Choose a frequency that works for you
  • Risk-free; cancel any time
USD 89.0

Value $125.00

$89.00

Save: $36.00

Or subscribe for savings up to 40% Initial payment Save 15% off your initial purchase and 40% off recurring orders
Quantity

( 0 item in your basket items in your basket )

Item already in basket as a one time purchase. If you also wish to subscribe to the same item please make 2 separate checkout purchases.
Item already in basket as subscription item. If you also wish to buy as a one time purchase please make 2 separate checkout transactions.
This selection is not currently available on a subscription plan. Please try making an alternative selection.
 

In stock

-

Usually dispatched within 24 hours

Live Chat

Average connection time 25 secs

Average connection time 25 secs

What Really Causes Acne?

Excess oil, acne-causing bacteria and inflammation are the culprits, and you need to treat all three.

Unlike most other acne treatment systems on the market, Perricone MD Acne Relief selectively targets and gently treats all three causes of acne - excess oil, acne-causing bacteria and inflammation. Many other brands rely on harsh chemicals that just kill all bacteria, or aggressively strip your skin of necessary hydration, which can upset skin’s natural microbiome and lead to irritation and dryness.  Rather than wash away all oil and bacteria, Acne Relief is designed to work symbiotically with skin’s microbiome to remove excess oil while simultaneously depositing hydrators that won’t dry skin out. 

Our Prebiotic Approach

Understand the science and benefits behind creating a healthy microbiome and balanced skin.

The patent-pending science behind Acne Relief is our prebiotic approach, a system that adapts to your skin’s unique microbiome to target troublesome acne. Using naturally occurring prebiotics, Acne Relief helps your skin safely and gently fight back against acne without disrupting its natural balance. The result? An effective defense against acne-causing bacteria that promotes a clear, blemish-free complexion.

Below are some of the key ingredients in Acne Relief behind our prebiotic approach:

Sucrose: Exfoliate & Support a Healthy Skin Biome

Milled to an ultra-fine sugar, this mild exfoliant helps unclog pores and remove excess dirt and oil without over-drying or stripping skin. Sucrose helps support a healthy skin biome by encouraging good bacteria and rinses off quickly and easily, making it ideal for gentle yet effective cleansing.

Citrulline: Fight Irritation & Visibly Reduce Redness

First discovered in watermelon, this alpha-amino acid visibly calms skin for a clearer, more even-looking complexion. Nourishing and soothing, it is an ideal way to counteract irritation.

Lactic & Succinic Acids: Attack Acne-Causing Bacteria

These short-chain fatty acids help quickly shrink blemishes by working alongside salicylic acid to attack acne-causing bacteria for a healthier skin microbiome. They also provide gentle yet effective exfoliation for smoother, more even-looking skin.

Niacinamide: Gentle Skin-Clearing Multi-Tasker

Also known as vitamin B3 and found in foods such as tomatoes, this skin-clearing powerhouse helps to gently and visibly erase imperfections, unclog oily pores and minimize uneven skin tone that can be left behind after breakouts by improving skin’s moisture barrier. Niacinamide is one of the essential vitamins skin needs to maintain a youthful look.

Squalane: Hydrate & Nourish

Found naturally in the human body and derived from olive oil, squalane hydrates without making skin look or feel greasy. This lightweight hydration is ideal for oil and acne-prone skin as it helps maintain optimal hydration without leaving skin feeling greasy and clogged.

Salicylic Acid: Pore-Minimizing, Anti-Acne Exfoliation

A beta-hydroxy acid (BHA), salicylic acid is a non-prescription treatment for acne and oil-prone skin. It quickly and effectively exfoliates and removes dead skin which can clog pores and cause breakouts. Because it is oil-soluble, salicylic acid is easily absorbed into pores for targeted, more effective results.

Retinol: Exfoliate for Clearer Skin & Accelerated Rejuvenation

This ultra-powerful, non-prescription vitamin A derivative helps prevent breakouts by unclogging pores and accelerating surface skin exfoliation and renewal. Retinol is the #1 dermatologist recommended, non-prescription skin-aging solution.

Acne Relief Gentle & Soothing Cleanser

Glycerin, Sodium Cocoyl Isethionate, Ethylhexyl Palmitate, Silica Cetyl Silylate, Sucrose, Squalane, Polyacrylamide, Water/ Aqua/Eau, Caprylyl Glycol, C13-14 Isoparaffin, Laureth-7, Phenoxyethanol

Acne Relief Calming Treatment & Hydrator

Water/Aqua/Eau, SD Alcohol 40-B, Glycerin, C12-15 Alkyl Lactate, PVP, Dimethicone, Polysorbate 20, Citrulline, Squalane, Lactic Acid, Succinic Acid, Polyacrylamide, Dimethicone/Vinyl Dimethicone Crosspolymer, C13-14 Isoparaffin, Laureth-7, Phenoxyethanol, Sodium Benzoate, Potassium Sorbate

Acne Relief Retinol Treatment & Moisturizer

Water/Aqua/Eau, SD Alcohol 40-B, Glycerin, Dicaprylyl Ether, Niacinamide, Citrulline, Arginine, Methyl Gluceth-20, Cetearyl Alcohol, Carbomer, Xanthan Gum, Tocopheryl Acetate, Retinol, Citric Acid, Sodium Hydroxide, Disodium EDTA, PEG-20 Methyl Glucose Sesquistearate, PEG-100 Stearate, Glyceryl Stearate, Methyl Glucose Sesquistearate, Polysorbate 20, Phenoxyethanol, Sodium Benzoate, Potassium Sorbate

Range:
Acne Relief
Brand:
Perricone MD
Volume:
2 x 2 fl.oz / 6 fl.oz - 2 x 59ml / 177ml
Directions:

Step 1: Day & Night Acne Relief Gentle & Soothing Cleanser

Lather a quarter-sized amount in hands & gently massage onto damp skin. Rinse thoroughly with warm water. For best results, follow with ACNE RELIEF Calming Treatment & Hydrator in the morning & ACNE RELIEF Retinol Treatment & Moisturizer in the evening.

Step 2: Day  Acne Relief Calming Treatment & Hydrator

Shake well. Apply a thin, even layer to skin in the morning. For best results, use after cleansing with ACNE RELIEF Gentle & Soothing Cleanser.

Step 2: Night Acne Relief Retinol Treatment & Moisturizer

Shake well. Apply a thin, even layer to skin in the evening. For best results, use after cleansing with ACNE RELIEF Gentle & Soothing Cleanser.

Customer Reviews

Overall Rating : 4.38 / 5 (597 Reviews)
  • 391 5 star reviews
  • 112 4 star reviews
  • 47 3 star reviews
  • 22 2 star reviews
  • 25 1 star reviews
See all reviews
 

Top Customer Reviews

Where reviews refer to foods or cosmetic products, results may vary from person to person. Customer reviews are independent and do not represent the views of The Hut Group.

I like this product

I have occasional breakouts with cystic looking acne. I use this product and I am satisfied with it as it seems to be keeping acne away. My problem is that I have been using the acne products morning and night and would like to use Perricone products that I have been using for years now that the acne seems OK. Do I stop using the acne system or combine the products that I have used for years with the acne products?? I have been using Perricone face creams and serums for years and don't know how to use the products now.

Was this review helpful to you?

Yes (0) No (0)
Report this review

I have more breakouts after using!

This is the absolute worst product I’ve ever used on my face. I never had breakouts as a teen, but developed cystic acne and problem skin in my 30s. Now in my early 40s, I am in an all-out war with my skin. I suffer from oily, porous, sensitive skin that will take forever to clear up of a major breakout, only to breakout all over again. So far the only products that I saw any real improvement w/ contained benzoyl peroxide, but that over dries my skin, causing a whole new set of problems. After watching the slick marketing video on Perricone MD’s Acne Relief System, I thought I’d give it a try b/c they specifically mention ingredients that aren’t harsh or abrasive to your skin. Well… I should have read the small print (i.e. the INGREDIENTS list) because that video fails to mention the ACTIVE INGREDIENT in all three of these products is Salicylic Acid! And there is nothing Calm or Soothing about Salicylic Acid!  Within one week of using these products as recommended my breakouts were Bigger, Redder and Angrier looking - not to mention more painful than I could bear. It hurt to even touch my face. But, I kept on using thinking this was just the product working and it would ease up once my skin got used to it. Unfortunately, that was not the case for me. I got more breakouts; big, red, angry ones and the skin on my face was always inflamed  and painful to the touch. After nearly 3 weeks I finally realized the product wasn’t working and stopped using it and my skin instantly thanked me.  Let this be a warning to anyone who has sensitive skin: DO NOT USE IF YOU ARE SENSITIVE TO HARSH CHEMICALS! I went back to my all-natural face wash scrub from Dirty Works and my skin healed w/in 2 weeks - all except a massive crater/scar on one cheek that was the worst of my breakouts from using this product. It’s taking much longer to heal and will certainly leave me with a very large scar on my cheek. So thanks for that Perricone. Not only am I out the $$, but I’m literally scarred for life.

Was this review helpful to you?

Yes (1) No (1)
Report this review

great for kids and and teens

We´ve been using this products for over a month and they really help

Was this review helpful to you?

Yes (1) No (0)
Report this review

Amazing

My face has never been so clear and healthy. I could see the difference when I don't use it regularly.

Was this review helpful to you?

Yes (0) No (0)
Report this review

Acne set

I don’t recommend this set at all it hurt my face really and and just made my acne flare really bad and it literally just rubes off your skin and it’s very expensive for the quality u get 

Was this review helpful to you?

Yes (0) No (1)
Report this review

Amazing.

I have combination tan skin, oily, blackheads & enlarged pores on my nose area and then dry everywhere else. Maskne was real and I believe stress caused a lot of acne lately. I tried the full regimen and now I can’t live without it. Really worth the investment. My pores are refined and my skin is glowy. I feel like I’m getting closer to my skin pre-pandemic.

Was this review helpful to you?

Yes (2) No (0)
Report this review

Used for nearly two months now..

Like the title said, I’ve been using these products for two months now and I have seen great results. I bought my first 30day kit at Nordstrom and my skin just instantly felt clean so I decided to get the full kit along with the pore minimizer. I developed acne along my jaw line due to stress and wearing a mask everyday. I had awful hard pimples deep in my skin that hurt. My skin was dull dry yet oily and I also had small broken veins with lots of redness. My skin today is totally different! My skin is shines and feels clean. The acne along my jaw is gone, I only have discoloring from the pimples. I also don’t get as oily anymore. This is a wonderful product. I have been taking photos of my progress which I will post to Nordstrom’s website since I can’t here. Try this product for at least two months to see results. 

Was this review helpful to you?

Yes (4) No (0)
Report this review

Incessant cystic breakout finally fixed

In high school, I thought I was the lucky one who wouldn't have acne because my skin was essentially clear except for the occasional blemish that would pop up when I was PMSing. Into my freshman and sophomore year of college, my skin still looked smooth and glowy, and I thought I was out of the woods when I turned 20. The summer before my junior year of college, my skin started to go downhill. I've had a non-stop cystic breakout since about September 2019. As soon as one cyst would start healing, another would pop up somewhere else. I told my parents that I would be going to a dermatologist to beg to be put on Accutane around Thanksgiving of last year. My parents got me this set for Christmas. I didn't think it would help much for cystic acne, and that's true for pre-existing breakouts. The cysts I already had didn't get much benefit from this kit, but now that those are healing, I haven't had any new breakouts. The first week of the kit brought a "purge" with smaller blemishes coming to a head (which I never get) and my previous cysts holding on strong. The second week, everything started to clear up. I'm in the third week now, and the only marks left on my skin are the few scars from the worst of my past cysts. No new breakouts, no small bumps, no cysts. The kit is expensive, so I'll be going to a dermatologist to try to get a prescription salicylic acid regimen that I can partially cover with my insurance. This is exactly what my skin needed to take a more PROACTIVE approach to cystic acne rather than the REACTIVE approach that works with other types of breakouts. You also can't beat a two step regimen when you've been trying so many products on your own.

Was this review helpful to you?

Yes (2) No (0)
Report this review

Clearer skin

I am in my early 40s and have sensitive, acne-prone skin. I know that hormones and diet play a big part in the condition of my skin besides just cleansers and moisturizers, but this regimen has greatly improved the appearance of my skin. I am so happy I have found these products. The blackheads on my nose have diminished as well as chin breakouts.

Was this review helpful to you?

Yes (0) No (0)
Report this review

Love this product

I’ve used multiple acne treatments expensive only can be shipped treatments and they didn’t work or made my face really dry. I decided to give this a try and it’s only been a week and I can see a big difference in my skin. My acne is clearing within days. My skin is looking clear and soft. I’m 32 and still shouldn’t get acne but I do especially during that time of the month. This doesn’t burn my skin like others I have tried and I honestly believe this is working great for my skin. I have a combination of skin in the morning when I wake up it’s oily and through out the day it’s dry. My pores look amazing as well. 

Was this review helpful to you?

Yes (3) No (0)
Report this review

Other customers bought: