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Neuropeptide Night Cream

Twenty years of research have yielded our most advanced night cream in our Neuropeptide Collection. Neuropeptide Night Cream is an ultra-rich firming night cream that nourishes skin with amino acids for essential hydration.

Additionally, it actively tackles the appearance of deep lines and wrinkles. Formulated with Neuropeptides for wrinkles and sagging along with DMAE to help visibly lift skin, this revolutionary deep wrinkle cream is also the ideal treatment for nasolabial folds and marionette lines. Wake up to smoother, healthier-looking skin.

What It Does

  • Addresses the 4-types of wrinkles: Fine Lines, Static Wrinkles, Dynamic Wrinkles and Gravitational Wrinkles.
  • DMAE works with the body’s natural repair cycle to help rejuvenate the skin and deliver visible results night after night.
  • A visible increase in radiance and glow, overnight.
  • Improved appearance of skin resilience, tone and texture.
  • Maximized regeneration and hydration of the skin.

What To Expect

Due to the science and compounds used in our products the feel and scent may vary.

Texture: Cream

Consistency: Luxurious & Rich

Scent: Natural

* This product is free from fish, milk, phthalates, sulfates, parabens, talc, and mineral oil. Cruelty-free and 100% vegan.

DMAE: Instant Firming

Naturally produced by the human brain, DMAE helps visibly lift sagging skin over time. Easily and quickly absorbed, it visibly plumps skin to help support skin's surface and protect against drying environmental aggressors.

Neuropeptides: Uniting Surface Cells to Fight Wrinkles

Powerful, protein-like building blocks offer the ultimate visible antidote to wrinkles, sagging, dullness, and discoloration. Neuropeptides encourage surface skin cells to work together via a unique chemical structure.

Amino Acids: Build Stronger Skin

Organic compounds that make up 75% of the human body, amino acids hydrate for firmer, smoother looking skin, strengthen surface skin cells, and have been used for a variety of skin conditions.

Ingredients

Water/Aqua/Eau, Glycerin, Isononyl Isononanoate, Pentaerythrityl Tetraethylhexanoate, Cetearyl Alcohol, Butyrospermum Parkii (Shea) Butter, C12-20 Acid PEG-8 Ester, Dimethyl Isosorbide, C10-18 Triglycerides, Isodecyl Salicylate, Butylene Glycol, Hydroxyethyl Acrylate/Sodium Acryloyldimethyl Taurate Copolymer, Squalane, C12-15 Alkyl Benzoate, Dimethicone, Polymethyl Methacrylate, Dimethyl MEA, Acetyl Hexapeptide-8, Pentapeptide-18, Tetrapeptide-21, Dipeptide-2, Palmitoyl Tetrapeptide-7, Palmitoyl Hexapeptide-12, Tyrosine, Tocopheryl Acetate, Dipotassium Glycyrrhizate, Hesperidin Methyl Chalcone, Ceramide NG, Fructose, Allantoin, Trehalose, Maltose, Glucose, Sodium Hyaluronate, Citric Acid, Sodium Hydroxide, Disodium EDTA, Sodium Chloride, Steareth-20, Polysorbate 60, Caprylyl Glycol, Tribehenin, Coco-Glucoside, Pentylene Glycol, Hexylene Glycol, Urea, PEG-10 Rapeseed Sterol, Sodium Lactate, Sodium PCA, Phenoxyethanol, Potassium Sorbate, Fragrance/Parfum, Linalool, Limonene.

Brand:
Perricone MD
Range:
Neuropeptide
Directions:

Massage onto cleansed face and neck in the evening using a gentle upward motion. Wait until fully absorbed, then follow with your favorite Perricone MD moisturizer if necessary.

Volume:
2.5 fl. oz

Neuropeptide Night Cream

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Ultimate On-the-go Kit
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Enjoy an On-The-Go gift when you spend $75, $125 Or $200

Complimentary gift will be awarded at the cart. Offer valid for a limited time only, while stocks last.

Spend $75 to receive an On-The-Go Duo (worth $49)

Spend $125 and receive a Deluxe On-The-Go kit (Worth $141)

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Ultimate On-the-go Kit
Ultimate On-the-go Kit Worth $180.88
Enjoy an On-The-Go gift when you spend $75, $125 Or $200
Complimentary gift will be awarded at the cart. Offer valid for a limited time only, while stocks last.

Spend $75 to receive an On-The-Go Duo (worth $49)

Spend $125 and receive a Deluxe On-The-Go kit (Worth $141)

Spend $200 to receive the Ultimate On-The-Go Kit (Worth $186)

View All

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Twenty years of research have yielded our most advanced night cream in our Neuropeptide Collection. Neuropeptide Night Cream is an ultra-rich firming night cream that nourishes skin with amino acids for essential hydration.

Additionally, it actively tackles the appearance of deep lines and wrinkles. Formulated with Neuropeptides for wrinkles and sagging along with DMAE to help visibly lift skin, this revolutionary deep wrinkle cream is also the ideal treatment for nasolabial folds and marionette lines. Wake up to smoother, healthier-looking skin.

What It Does

  • Addresses the 4-types of wrinkles: Fine Lines, Static Wrinkles, Dynamic Wrinkles and Gravitational Wrinkles.
  • DMAE works with the body’s natural repair cycle to help rejuvenate the skin and deliver visible results night after night.
  • A visible increase in radiance and glow, overnight.
  • Improved appearance of skin resilience, tone and texture.
  • Maximized regeneration and hydration of the skin.

What To Expect

Due to the science and compounds used in our products the feel and scent may vary.

Texture: Cream

Consistency: Luxurious & Rich

Scent: Natural

* This product is free from fish, milk, phthalates, sulfates, parabens, talc, and mineral oil. Cruelty-free and 100% vegan.

DMAE: Instant Firming

Naturally produced by the human brain, DMAE helps visibly lift sagging skin over time. Easily and quickly absorbed, it visibly plumps skin to help support skin's surface and protect against drying environmental aggressors.

Neuropeptides: Uniting Surface Cells to Fight Wrinkles

Powerful, protein-like building blocks offer the ultimate visible antidote to wrinkles, sagging, dullness, and discoloration. Neuropeptides encourage surface skin cells to work together via a unique chemical structure.

Amino Acids: Build Stronger Skin

Organic compounds that make up 75% of the human body, amino acids hydrate for firmer, smoother looking skin, strengthen surface skin cells, and have been used for a variety of skin conditions.

Ingredients

Water/Aqua/Eau, Glycerin, Isononyl Isononanoate, Pentaerythrityl Tetraethylhexanoate, Cetearyl Alcohol, Butyrospermum Parkii (Shea) Butter, C12-20 Acid PEG-8 Ester, Dimethyl Isosorbide, C10-18 Triglycerides, Isodecyl Salicylate, Butylene Glycol, Hydroxyethyl Acrylate/Sodium Acryloyldimethyl Taurate Copolymer, Squalane, C12-15 Alkyl Benzoate, Dimethicone, Polymethyl Methacrylate, Dimethyl MEA, Acetyl Hexapeptide-8, Pentapeptide-18, Tetrapeptide-21, Dipeptide-2, Palmitoyl Tetrapeptide-7, Palmitoyl Hexapeptide-12, Tyrosine, Tocopheryl Acetate, Dipotassium Glycyrrhizate, Hesperidin Methyl Chalcone, Ceramide NG, Fructose, Allantoin, Trehalose, Maltose, Glucose, Sodium Hyaluronate, Citric Acid, Sodium Hydroxide, Disodium EDTA, Sodium Chloride, Steareth-20, Polysorbate 60, Caprylyl Glycol, Tribehenin, Coco-Glucoside, Pentylene Glycol, Hexylene Glycol, Urea, PEG-10 Rapeseed Sterol, Sodium Lactate, Sodium PCA, Phenoxyethanol, Potassium Sorbate, Fragrance/Parfum, Linalool, Limonene.

Brand:
Perricone MD
Range:
Neuropeptide
Directions:

Massage onto cleansed face and neck in the evening using a gentle upward motion. Wait until fully absorbed, then follow with your favorite Perricone MD moisturizer if necessary.

Volume:
2.5 fl. oz

Customer Reviews

Overall Rating : 4.3 / 5 (30 Reviews)
  • 23 5 star reviews
  • 0 4 star reviews
  • 2 3 star reviews
  • 3 2 star reviews
  • 2 1 star reviews
See all reviews
 

Top Customer Reviews

Where reviews refer to foods or cosmetic products, results may vary from person to person. Customer reviews are independent and do not represent the views of The Hut Group.

I will definitely buy again

I love this moisturizer, I use it every night after I wash my face. It's got a thick texture but blends so well at the same time. My skin has definitely improved since I started using Perricone. I'm almost 50 and my skin is pretty healthy.

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I would totally buy this again!

I love this product! It's so rich, leaving my skin feeling plump and hydrated. It is pricier than my regular evening cream, but a little goes a long way. I used about a pea size and that's enough for my face and neck.

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Great night cream

I use this cream after a retinal application to prevent dryness.

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Be aware do not use this product

Nothing is good about it . I am in to my 5 th week from stopping using this cream and it feels like someone has poured acid over my face . It's bright red/ burning / itching / dry and tight And flaking. I am under the doctor at the moment for this bad reaction it hasn't got any better from start to finish . Well there is no finish it's still bad 5 weeks on .

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I wouldn't buy it again

I used this product 3 times and every time my skin Was itching ( specially on My chin and mouth corners) and red . It also went dry all over my chin and sides of mouth And dry patches here and there on my face . I do not have dry skin a bit oily to be fair but it is sensitive . My skin now feels tight and dryish. I will use it on my hands rather than waste my money throwing it away .

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Gave me a TERRIBLE breakout

I was looking for a moisturizing night cream without coconut oil or retinol for my dry, sensitive skin and to reduce the fine lines around my eyes, again without sensitizing retinol. This product seemed right up my alley. (The medium-chain triglycerides that are coconut derived have never given me issues in other products. Shea butter and dimethicone dont give me issues. None of the emulsifiers listed on the ingredients have been comedogenic for me though Ive never tried peptide products.). Within a handful of nights of recommended use (dime sized amount, thoroughly massaged into the skin after cleansing), my forehead broke out in over a dozen tiny, red blemishes. My skin is definitely moisturized, but looks like a pepperoni pizza. I havent had a breakout like this in over 10 years. I gave my rating 2 stars because even though it is very moisturizing and had already marginally reduced the lines around my eyes in just a few applications, those benefits are vastly outweighed by the blemishes. In the attached photo, you can see the new breakouts forming on my forehead. This was my first purchase of a Perricone MD product and I'm incredibly disappointed.

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Visible Results

Am 52 and use Perricone supplemts. Got this as a sample gift and starting using 6 weeks ago. I can see a dramatic difference - skin is smoother & brighter, beginnings of lines between nose & mouth gone, really deep wrinkles between eyes are improved. Biggest change is my neck - skin much less haggard looking. There was a big difference between how old my neck looked vs my face. Now not so much. Also, I have incredibly sensitive skin and am allergic to most anti-aging treatments. My skin is very happy with this.

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I would not buy this product again

It feels great on. I'm just not seeing if feeling any difference.

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An essential

I'm a Neuropeptide kinda girl...girl(?); I'm 67 years old. I've been using Perricone products since I was in my early 50s and will use nothing else on my face and neck. This particular product, the Neuropeptide Facial Cream and the Nutritive Cleanser are my daily 'go to'. I will not miss one single day of using these products. They have helped my face keep a fresh, healthy look. I know I'll never again be young; but, I do want to look the best 60- or 70- something I could be. Perricone products help me achieve that goal. If you've never used Perricone products, I'm here to tell you, just give it a try--you will never be sorry.

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Love this lightweight night cream

I am very pleased with the effectiveness of this lightweight neuropeptide night cream. It is an excellent addition to my skincare routine. I recommend this product.

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