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Twenty years of research have yielded our most advanced and comprehensive night treatment cream. This ultra-rich moisturizer works overnight to nourish skin with essential hydration and over time actively fights the appearance of deep lines and wrinkles, including nasolabial folds and marionette lines. Wake up to dramatically younger, smoother, healthier-looking skin.
What It Does
- Addresses the 4-types of wrinkles: Fine Lines, Static Wrinkles, Dynamic Wrinkles and Gravitational Wrinkles.
- Works with the body’s natural repair cycle to help rejuvenate the skin and deliver visible results night after night.
- Visibly and dramatically softens the appearance of deep lines and creases.
- Nourishes the skin with essential hydration.
What To Expect
Due to the science and compounds used in our products the feel and scent may vary.
Texture: Cream
Consistency: Luxurious & Rich
Scent: Natural
* This product is free from fish, milk, phthalates, sulfates, parabens, talc, and mineral oil. Cruelty-free and 100% vegan.
Consumer Results
93% agreed skin looked and felt more supple*
91% agreed skin looked and felt smoother*
83% agreed skin appeared rested, renewed and restored*
83% agreed they saw improvement in the appearance of surface fine lines*
78% agreed they saw improvement in the appearance of static and stubborn wrinkles*
*In a consumer study of 54 women after 28 days.
Neuropeptides: Uniting Surface Cells to Fight Wrinkles
Powerful, protein-like building blocks offer the ultimate visible antidote to the look of wrinkles, sagging, dullness and discoloration. Neuropeptides support skin’s barrier and hydration via a unique chemical structure.
DMAE: Intensive Firming
Naturally produced by the human brain, DMAE helps visibly lift sagging skin over time. Easily and quickly absorbed, it visibly plumps skin to help support skin’s surface and protect against drying environmental aggressors.
Amino Acids: Build Stronger Skin
Organic compounds that make up over 20% of the human body, amino acids hydrate for firmer, smoother looking skin, help strengthen surface skin cells and have been used for a variety of skin benefits.
Ingredients:
Water/Aqua/Eau, Glycerin, Isononyl Isononanoate, Pentaerythrityl Tetraethylhexanoate, Cetearyl Alcohol, Butyrospermum Parkii (Shea) Butter, C12-20 Acid PEG-8 Ester, Dimethyl Isosorbide, C10-18 Triglycerides, Isodecyl Salicylate, Butylene Glycol, Hydroxyethyl Acrylate/Sodium Acryloyldimethyl Taurate Copolymer, Squalane, C12-15 Alkyl Benzoate, Dimethicone, Polymethyl Methacrylate, Dimethyl MEA, Acetyl Hexapeptide-8, Pentapeptide-18, Tetrapeptide-21, Dipeptide-2, Palmitoyl Tetrapeptide-7, Palmitoyl Hexapeptide-12, Tyrosine, Tocopheryl Acetate, Dipotassium Glycyrrhizate, Hesperidin Methyl Chalcone, Ceramide NG, Fructose, Allantoin, Trehalose, Maltose, Glucose, Sodium Hyaluronate, Citric Acid, Sodium Hydroxide, Disodium EDTA, Sodium Chloride, Steareth-20, Polysorbate 60, Caprylyl Glycol, Tribehenin, Coco-Glucoside, Pentylene Glycol, Hexylene Glycol, Urea, PEG-10 Rapeseed Sterol, Sodium Lactate, Sodium PCA, Phenoxyethanol, Potassium Sorbate, Fragrance/Parfum, Linalool, Limonene
- Neuropeptide
- Perricone MD
- 2.5 fl.oz / 75ml
Massage onto cleansed face and neck in the evening using a gentle upward motion. Wait until fully absorbed, then follow with your favorite Perricone MD moisturizer if necessary.
Neuropeptide Night Cream
This ultra-rich night cream visibly and dramatically softens the appearance of deep lines and creases by deeply nourishing and hydrating.
Earn 720 reward points when purchasing this product*
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$240.00
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4 installments of $60.00 with afterpay Learn more
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4 installments of $60.00 with zip Learn more
SAVE 30% WITH CODE: APRILFOOLS
Offer valid through 04/02/2023 or while supplies last. Exclusions include but not limited to Cold Plasma Plus+ The Essence, Cold Plasma Plus+ Lip Therapy, High Potency Face Firming & Finishing Toner, High Potency Retinol Recovery Overnight Moisturizer, High Potency Hyaluronic Intensive Body Therapy, Vitamin C Ester CCC + Ferulic Brightening Complex 20%,Vitamin C Ester Intensive Dark Spot Treatment, kits, cosmetic and tote bags, boxed sets and trial sizes. Offer cannot be combined with other discounts or applied to past purchases. Offers and promotions may be subject to additional terms and conditions.
Offer valid through 04/02/2023 or while supplies last. Exclusions include but not limited to Cold Plasma Plus+ The Essence, Cold Plasma Plus+ Lip Therapy, High Potency Face Firming & Finishing Toner, High Potency Retinol Recovery Overnight Moisturizer, High Potency Hyaluronic Intensive Body Therapy, Vitamin C Ester CCC + Ferulic Brightening Complex 20%,Vitamin C Ester Intensive Dark Spot Treatment, kits, cosmetic and tote bags, boxed sets and trial sizes. Offer cannot be combined with other discounts or applied to past purchases. Offers and promotions may be subject to additional terms and conditions.
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Twenty years of research have yielded our most advanced and comprehensive night treatment cream. This ultra-rich moisturizer works overnight to nourish skin with essential hydration and over time actively fights the appearance of deep lines and wrinkles, including nasolabial folds and marionette lines. Wake up to dramatically younger, smoother, healthier-looking skin.
What It Does
- Addresses the 4-types of wrinkles: Fine Lines, Static Wrinkles, Dynamic Wrinkles and Gravitational Wrinkles.
- Works with the body’s natural repair cycle to help rejuvenate the skin and deliver visible results night after night.
- Visibly and dramatically softens the appearance of deep lines and creases.
- Nourishes the skin with essential hydration.
What To Expect
Due to the science and compounds used in our products the feel and scent may vary.
Texture: Cream
Consistency: Luxurious & Rich
Scent: Natural
* This product is free from fish, milk, phthalates, sulfates, parabens, talc, and mineral oil. Cruelty-free and 100% vegan.
Consumer Results
93% agreed skin looked and felt more supple*
91% agreed skin looked and felt smoother*
83% agreed skin appeared rested, renewed and restored*
83% agreed they saw improvement in the appearance of surface fine lines*
78% agreed they saw improvement in the appearance of static and stubborn wrinkles*
*In a consumer study of 54 women after 28 days.
Neuropeptides: Uniting Surface Cells to Fight Wrinkles
Powerful, protein-like building blocks offer the ultimate visible antidote to the look of wrinkles, sagging, dullness and discoloration. Neuropeptides support skin’s barrier and hydration via a unique chemical structure.
DMAE: Intensive Firming
Naturally produced by the human brain, DMAE helps visibly lift sagging skin over time. Easily and quickly absorbed, it visibly plumps skin to help support skin’s surface and protect against drying environmental aggressors.
Amino Acids: Build Stronger Skin
Organic compounds that make up over 20% of the human body, amino acids hydrate for firmer, smoother looking skin, help strengthen surface skin cells and have been used for a variety of skin benefits.
Ingredients:
Water/Aqua/Eau, Glycerin, Isononyl Isononanoate, Pentaerythrityl Tetraethylhexanoate, Cetearyl Alcohol, Butyrospermum Parkii (Shea) Butter, C12-20 Acid PEG-8 Ester, Dimethyl Isosorbide, C10-18 Triglycerides, Isodecyl Salicylate, Butylene Glycol, Hydroxyethyl Acrylate/Sodium Acryloyldimethyl Taurate Copolymer, Squalane, C12-15 Alkyl Benzoate, Dimethicone, Polymethyl Methacrylate, Dimethyl MEA, Acetyl Hexapeptide-8, Pentapeptide-18, Tetrapeptide-21, Dipeptide-2, Palmitoyl Tetrapeptide-7, Palmitoyl Hexapeptide-12, Tyrosine, Tocopheryl Acetate, Dipotassium Glycyrrhizate, Hesperidin Methyl Chalcone, Ceramide NG, Fructose, Allantoin, Trehalose, Maltose, Glucose, Sodium Hyaluronate, Citric Acid, Sodium Hydroxide, Disodium EDTA, Sodium Chloride, Steareth-20, Polysorbate 60, Caprylyl Glycol, Tribehenin, Coco-Glucoside, Pentylene Glycol, Hexylene Glycol, Urea, PEG-10 Rapeseed Sterol, Sodium Lactate, Sodium PCA, Phenoxyethanol, Potassium Sorbate, Fragrance/Parfum, Linalool, Limonene
- Neuropeptide
- Perricone MD
- 2.5 fl.oz / 75ml
Massage onto cleansed face and neck in the evening using a gentle upward motion. Wait until fully absorbed, then follow with your favorite Perricone MD moisturizer if necessary.
Customer Reviews
Top Customer Reviews
Where reviews refer to foods or cosmetic products, results may vary from person to person. Customer reviews are independent and do not represent the views of The Hut Group.
The best
This is the best cream I have ever experienced in my life. I am 65 yrs young and have very dry skin..my husband says I look so good!! And that's "good" for him!!!😊
Report this reviewRich
Nice rich cream I have sensitive skin and didn't bother it at all wake up to a nice glow
Report this reviewAmazing
Fantastic, nourishing, moisturising night cream for dry skin. Adds glow, firms up the skin and I wake up ewith my skin still moisturised after a night of sleep. Just great!
Top Reviewer
Wanted to love this
I appreciate Perricone. The actives & formulations can be effective. I've seen results with other products, so I splurged after reading reviews. I'm 51 & looking for something that addresses all of my concerns- wrinkles/creases, pores/texture, and loss of firmness around jawline/chin. This product had a lot of promise & I bought it specifically due to the DMAE. Used it consistently for 30 days. It did lighten a prominent crease in my forehead and I think some improvement in firmness, but did nothing for creases at the corners of my mouth or gravitational wrinkles on my chin. These lines are still in a soft category, but I still saw no improvement whatsoever. It also caused deep cystic acne outbreaks between my lip and chin. Its a very greasy formula, it practically melts into an oil from the heat of your skin. I tried to return but they only accept unopened product. I will not buy direct from their website again. Another product that I received with my order was set to expire in JUNE(3 months). They are replacing it. Just a warning to check your expiration dates.
Report this reviewSilky
I bought this cream wanting to try this line. It is thick but not too thick. It melts into my skin beautifully. No heavy scent and the moisture lasts.
Report this reviewLove Perricone
I've been using Perricone for 20 years and the results are amazing. Love Perricone
Report this reviewNighttime Facial cream
Just love this facial cream! It is smooth, applies beautifully and is a wonderful deep overnight moisturizer.Â
Report this reviewTotally Works!
I have ALL Perricone skincare! After I use up the subD serum, am staying with the C and Retinol and THIS! It literally has changed my face! In one application I saw a difference! So I ordered the day one too! It even works on my eyes! The BEST anti-aging cream I EVER used and I am 68! Its worth every nickel, especially with the new payment plans. And it takes such a small amount too. It works on my neck too! Great product, is a holy trail for sure!
Report this reviewTotally Works!I
I switched skincare lines since I'm older now. Felt I needed something stronger at 68. Always wanted to try this line and thanks to Afterpay and Klarna, I have been able to. This is my last purchase for awhile as I have the two serums and another on the way, face finishing moisturizer, deep crease serum,sub d neck cream and more. This has totally changed my skin. I don't look forty, but my skin looks great, wrinkles are literally disappearing. My neck looks so much better. But it has taken about three months,which is fine with me. I didn't get these in a month. It took years. This cream just puts the finishing touch on it all. Thank you.
Report this reviewMy new nighttime ritual
My first experience with the neuropeptide products was the facial cream. I was so impressed after a few months that I added this to my skincare routine. My first tube separated, meaning I had to shake it vigorously before squirting any out or I would only get oil. When the tube was almost empty I cut it open and found the rich, emollient cream in the bottom of the tube. Knowing that Perricone products don’t have the greatest shelf life, I tried a second tube and it was perfect. You need to watch for this, Perricone! This is an expensive product; however, it’s a good one. I love what the combo of the day and night cream has done. My skin sensitivity is gone and my skin appears thicker. At age 64, with a thin face, I need all the help I can get to plump up my skin. I don’t need an additional nighttime moisturizer. This cream is enough.
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