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Highly-potent serum with a silky, luxurious texture absorbs quickly to smooth the look of even the most stubborn, deep-set lines, wrinkles and creases around the mouth, eyes, lips and forehead, including marionette lines, frown lines, smile lines and nasolabial folds. Over time, these engraved imperfections appear shallower and expression lines appear erased, as the vitamin F blend works to replenish skin’s moisture barrier and protect it from environmental aggressors.

What It Does

  • Softens the look of facial lines from daily repetitive movements.
  • Visibly improves etched creases making them appear more shallow.
  • Minimizes the appearance of skin imperfections and imparts a beautiful radiance.

What To Expect

Due to the science and compounds used in our products the feel and scent may vary.

Texture: Serum

Consistency: Lightweight

Scent:  Natural, aromatic rose

* This product is free from soy, nuts, gluten, fish, milk, corn, phthalates, sulfates, parabens, talc, and mineral oil. Cruelty-free.

Consumer Results

Overall Skin Condition:

93% noticed skin looked renewed*
84% saw that skin looked more toned*

Advanced Claims:

89% noticed an improvement in lines and texture*
86% felt firmer, tighter skin*
86% saw an improvement in expression lines*
84% saw that wrinkles were smoothed*
83% noticed creases appeared shallower and forehead lines appeared smoother*
82% saw tighter-looking skin*
80% saw lines smoothed around the mouth and lips*
79% noticed engraved imperfections appeared shallower*
77% noticed that skin looked lifted*
74% felt that skin looked dramatically younger*
73% saw that deep-set wrinkles, including marionette lines and nasolabial folds were smoothed*
*In a consumer study of 102 women after 28 days

Acyl-Glutathione: The Master Antioxidant

Comprised of 3 amino acids, glutathione is the body’s main antioxidant and as part of a comprehensive skincare regimen can help to reduce the look of wrinkles and creases by replenishing fragile skin. Natural levels of this essential building block deplete over time, but topical application can help skin appear smoother and more youthful.

Vitamin F Blend: Ultimate Moisture Barrier Protection

Flax, chia and macadamia seed oils work over time to restore suppleness and create a healthy glow by intensely moisturizing and improving skin’s moisture barrier. Essential, yet not naturally found in the human body.

Ingredients:

Water/Aqua/Eau, Propanediol, Squalane, Hydrogenated Polyisobutene, S-Palmitoylglutathione, Dimethicone, Glycerin, Macadamia Ternifolia Seed Oil, Xylitylglucoside, Tetrahexyldecyl Ascorbate, Dimethyl MEA, Palmitoyl Tripeptide-5, Acetyl Hexapeptide-8, Anhydroxylitol, Lactic Acid, Xylitol, Xanthan Gum, Linum Usitatissimum (Linseed) Seed Oil, Salvia Hispanica Seed Oil, Tocopherol, Ethylhexylglycerin, Magnesium Aspartate, Zinc Gluconate, Alaria Esculenta Extract, Glucose, Sodium Hyaluronate, Copper Gluconate, Tetradecyl Aminobutyroylvalylaminobutyric Urea Trifluoroacetate, Palmitoyl Dipeptide-5 Diaminobutyroyl Hydroxythreonine, Helianthus Annuus (Sunflower) Seed Oil, Rosmarinus Officinalis (Rosemary) Leaf Extract, Tetrasodium Glutamate Diacetate, Magnesium Chloride, Caprylic/Capric Triglyceride, Acrylates/C10-30 Alkyl Acrylate Crosspolymer, Caprylyl/Capryl Glucoside, Caprylyl Glycol, Potassium Sorbate, Phenoxyethanol, Fragrance/Parfum, Citronellol, Hydroxycitronellal, Limonene, Linalool

Range:
Essential Fx Acyl-Glutathione
Brand:
Perricone MD
Volume:
1 fl.oz / 30ml
Directions:

After cleansing, massage onto face and neck using a gentle upward motion. Wait until fully absorbed and follow with your favorite Perricone MD moisturizer. Use morning and evening.

Essential Fx Acyl-Glutathione Deep Crease Serum

Highly-potent serum to improve the appearance of deep creases, marionette and lip lines.

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Start the new year off right and get your favorites when you want them and save. Sign up for Auto Replenishment and save 30% on initial orders and recurring orders of select best sellers and 40% on initial orders and recurring orders of select Supplement and Acne Relief products. For a limited time
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Highly-potent serum with a silky, luxurious texture absorbs quickly to smooth the look of even the most stubborn, deep-set lines, wrinkles and creases around the mouth, eyes, lips and forehead, including marionette lines, frown lines, smile lines and nasolabial folds. Over time, these engraved imperfections appear shallower and expression lines appear erased, as the vitamin F blend works to replenish skin’s moisture barrier and protect it from environmental aggressors.

What It Does

  • Softens the look of facial lines from daily repetitive movements.
  • Visibly improves etched creases making them appear more shallow.
  • Minimizes the appearance of skin imperfections and imparts a beautiful radiance.

What To Expect

Due to the science and compounds used in our products the feel and scent may vary.

Texture: Serum

Consistency: Lightweight

Scent:  Natural, aromatic rose

* This product is free from soy, nuts, gluten, fish, milk, corn, phthalates, sulfates, parabens, talc, and mineral oil. Cruelty-free.

Consumer Results

Overall Skin Condition:

93% noticed skin looked renewed*
84% saw that skin looked more toned*

Advanced Claims:

89% noticed an improvement in lines and texture*
86% felt firmer, tighter skin*
86% saw an improvement in expression lines*
84% saw that wrinkles were smoothed*
83% noticed creases appeared shallower and forehead lines appeared smoother*
82% saw tighter-looking skin*
80% saw lines smoothed around the mouth and lips*
79% noticed engraved imperfections appeared shallower*
77% noticed that skin looked lifted*
74% felt that skin looked dramatically younger*
73% saw that deep-set wrinkles, including marionette lines and nasolabial folds were smoothed*
*In a consumer study of 102 women after 28 days

Acyl-Glutathione: The Master Antioxidant

Comprised of 3 amino acids, glutathione is the body’s main antioxidant and as part of a comprehensive skincare regimen can help to reduce the look of wrinkles and creases by replenishing fragile skin. Natural levels of this essential building block deplete over time, but topical application can help skin appear smoother and more youthful.

Vitamin F Blend: Ultimate Moisture Barrier Protection

Flax, chia and macadamia seed oils work over time to restore suppleness and create a healthy glow by intensely moisturizing and improving skin’s moisture barrier. Essential, yet not naturally found in the human body.

Ingredients:

Water/Aqua/Eau, Propanediol, Squalane, Hydrogenated Polyisobutene, S-Palmitoylglutathione, Dimethicone, Glycerin, Macadamia Ternifolia Seed Oil, Xylitylglucoside, Tetrahexyldecyl Ascorbate, Dimethyl MEA, Palmitoyl Tripeptide-5, Acetyl Hexapeptide-8, Anhydroxylitol, Lactic Acid, Xylitol, Xanthan Gum, Linum Usitatissimum (Linseed) Seed Oil, Salvia Hispanica Seed Oil, Tocopherol, Ethylhexylglycerin, Magnesium Aspartate, Zinc Gluconate, Alaria Esculenta Extract, Glucose, Sodium Hyaluronate, Copper Gluconate, Tetradecyl Aminobutyroylvalylaminobutyric Urea Trifluoroacetate, Palmitoyl Dipeptide-5 Diaminobutyroyl Hydroxythreonine, Helianthus Annuus (Sunflower) Seed Oil, Rosmarinus Officinalis (Rosemary) Leaf Extract, Tetrasodium Glutamate Diacetate, Magnesium Chloride, Caprylic/Capric Triglyceride, Acrylates/C10-30 Alkyl Acrylate Crosspolymer, Caprylyl/Capryl Glucoside, Caprylyl Glycol, Potassium Sorbate, Phenoxyethanol, Fragrance/Parfum, Citronellol, Hydroxycitronellal, Limonene, Linalool

Range:
Essential Fx Acyl-Glutathione
Brand:
Perricone MD
Volume:
1 fl.oz / 30ml
Directions:

After cleansing, massage onto face and neck using a gentle upward motion. Wait until fully absorbed and follow with your favorite Perricone MD moisturizer. Use morning and evening.

Customer Reviews

Overall Rating : 4.41 / 5 (245 Reviews)
  • 156 5 star reviews
  • 57 4 star reviews
  • 17 3 star reviews
  • 6 2 star reviews
  • 9 1 star reviews
See all reviews
 

Top Customer Reviews

Where reviews refer to foods or cosmetic products, results may vary from person to person. Customer reviews are independent and do not represent the views of The Hut Group.

Magic

I am so impressed with this deep crease serum, for me, it exceeded my hopes and expectations. I have been forming fine lines across my forehead from repetitive motions and stress!) and have been watching them grow deeper and spread further over time. I have tried other products with mild results, but this is the first serum that I have ever used where I can say that I actually see a significant difference in my skin. For the past month I have incorporated this serum every night as part of my PM skincare routine and the lines are not only fading, but some have actually disappeared... this stuff is magic! At first I only was using two drops on my forehead, but now I also use a drop on my smile lines and across the horizontal lines on my neck. I am so incredibly pleased with my results so far, I look forward to continued improvement of my skin with daily use. The price may be steep, but you truly use so little at a time and the results are noticeable and very real.

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Small reduction

Used over the past month, twice a day. Small reduction in my major forehead creases.

Reviewer of the Month

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The best serum ever

You would look at women posting their before and after pics and wonder about the depth of their facial creases, their age, life style, nutrition as a factors influencing wrinkles formation and leave the web site in disbelieve  I am asking you to believe me cause: I am 62, watching what I am eating, working my sweat by gardening and walking, taking my supplements. Never developed habit of using the sun scream Developed deep creases or so cold smile wrinkles long time ago. I thought it was it. Bought the first Dr Perricone book 3 years ago and started using his cream and serum 3 years ago 1 year Ago he came up with the new line of Fox essential glutathione eye and deep creases cerium, creams and so on Started using his deep crease Fx glutathione in January not even twice per day, just at night time I am telling the truth: my absolutely deep crease on the left side disappeared completely in April and the left side became much superficial by now I LOVE Dr Perricone and what he does for female not only beauty but self esteem and mood He definitely knows what woman wants 

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Love This Cream!

Got it in a kit! I completely changed over my skincare products from another company to Perricone MD after they allowed afterpay and klarna. I have been wanting to for awhile but couldn't afford the money all at once. Now I can. I got one half ounce with two other products. Been using for about a month. I only use it on my lines and wrinkles. Not my full face. For me, it works. On my forehead, and all around my mouth the lines are going away! When I run out, will buy the full size. This is the only skincare I have ever used that actually does what it says it's going to do! I've had good skincare,just not as good as this! Won't go back.

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Good name for product

Good product, does seem to help with marionette lines and lip lines.

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Not working

It’s been 10 days since I started using it every morning and evening, sometimes more in the afternoon but haven’t seen any results or improvement on my skin. I have a shallow wrinkle alongside my mouth and the serum doesn’t fade it. With that price, I expected it works after few days of using as I know my skin well, If anything works on my skin, i will see results immediately, I mean I can feel it right at the first time I put on my skin, but if I don’t feel anything I know nothing is coming. 

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I loved it

The results were immediate.

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Not heavy or sticky.

I'm enjoying this as a way to get more moisture and sun protection without heaviness or stickiness.

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I would buy this product again.

I think this product is very effective and I like the fact that the SPF factor comes from a natural source.

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Expensive but works!

I love the texture of this product. Although I do feel Perricone is overpriced I keep coming back for more!

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