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Highly-potent serum with a silky, luxurious texture absorbs quickly to smooth the look of even the most stubborn, deep-set lines, wrinkles and creases around the mouth, eyes, lips and forehead, including marionette lines, frown lines, smile lines and nasolabial folds. Over time, these engraved imperfections appear shallower and expression lines appear erased, as the vitamin F blend works to replenish skin’s moisture barrier and protect it from environmental aggressors.
What It Does
- Softens the look of facial lines from daily repetitive movements.
- Visibly improves etched creases making them appear more shallow.
- Minimizes the appearance of skin imperfections and imparts a beautiful radiance.
What To Expect
Due to the science and compounds used in our products the feel and scent may vary.
Texture: Serum
Consistency: Lightweight
Scent: Natural, aromatic rose
* This product is free from soy, nuts, gluten, fish, milk, corn, phthalates, sulfates, parabens, talc, and mineral oil. Cruelty-free.
After cleansing, massage onto face and neck using a gentle upward motion. Wait until fully absorbed and follow with your favorite Perricone MD moisturizer. Use morning and evening.
Consumer Results
Overall Skin Condition:
93% noticed skin looked renewed*
84% saw that skin looked more toned*
Advanced Claims:
89% noticed an improvement in lines and texture*
86% felt firmer, tighter skin*
86% saw an improvement in expression lines*
84% saw that wrinkles were smoothed*
83% noticed creases appeared shallower and forehead lines appeared smoother*
82% saw tighter-looking skin*
80% saw lines smoothed around the mouth and lips*
79% noticed engraved imperfections appeared shallower*
77% noticed that skin looked lifted*
74% felt that skin looked dramatically younger*
73% saw that deep-set wrinkles, including marionette lines and nasolabial folds were smoothed*
*In a consumer study of 102 women after 28 days
Acyl-Glutathione: The Master Antioxidant
Comprised of 3 amino acids, glutathione is the body’s main antioxidant and as part of a comprehensive skincare regimen can help to reduce the look of wrinkles and creases by replenishing fragile skin. Natural levels of this essential building block deplete over time, but topical application can help skin appear smoother and more youthful.
Vitamin F Blend: Ultimate Moisture Barrier Protection
Flax, chia and macadamia seed oils work over time to restore suppleness and create a healthy glow by intensely moisturizing and improving skin’s moisture barrier. Essential, yet not naturally found in the human body.
Ingredients:
Water/Aqua/Eau, Propanediol, Squalane, Hydrogenated Polyisobutene, S-Palmitoylglutathione, Dimethicone, Glycerin, Macadamia Ternifolia Seed Oil, Xylitylglucoside, Tetrahexyldecyl Ascorbate, Dimethyl MEA, Palmitoyl Tripeptide-5, Acetyl Hexapeptide-8, Anhydroxylitol, Lactic Acid, Xylitol, Xanthan Gum, Linum Usitatissimum (Linseed) Seed Oil, Salvia Hispanica Seed Oil, Tocopherol, Ethylhexylglycerin, Magnesium Aspartate, Zinc Gluconate, Alaria Esculenta Extract, Glucose, Sodium Hyaluronate, Copper Gluconate, Tetradecyl Aminobutyroylvalylaminobutyric Urea Trifluoroacetate, Palmitoyl Dipeptide-5 Diaminobutyroyl Hydroxythreonine, Helianthus Annuus (Sunflower) Seed Oil, Rosmarinus Officinalis (Rosemary) Leaf Extract, Tetrasodium Glutamate Diacetate, Magnesium Chloride, Caprylic/Capric Triglyceride, Acrylates/C10-30 Alkyl Acrylate Crosspolymer, Caprylyl/Capryl Glucoside, Caprylyl Glycol, Potassium Sorbate, Phenoxyethanol, Fragrance/Parfum, Citronellol, Hydroxycitronellal, Limonene, Linalool
- Essential Fx Acyl-Glutathione
- Perricone MD
- 1 fl.oz / 30ml
Frequently Bought Together



Total Price: $310.00
Add both to cart
Essential Fx Acyl-Glutathione Deep Crease Serum
Highly-potent serum to improve the appearance of deep creases, marionette and lip lines.
Earn 555 reward points when purchasing this product*
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$185.00
In stock
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4 installments of $46.25 with Klarna Learn more
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4 installments of $46.25 with afterpay Learn more
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4 installments of $46.25 with zip Learn more

40% OFF + $230 GIFT + 2X POINTS
*Offer valid through 12/12/2023 or while supplies last. Percent off marked on products. Gift with purchase is automatically applied at checkout. Offer excludes but is not limited to new products, travel sizes, boxed sets and bags. Offer cannot be combined with other discounts or applied to past or future purchases. Offers and promotions may be subject to additional terms and conditions. Additional exclusions may apply.

*Offer valid through 12/12/2023 or while supplies last. Percent off marked on products. Gift with purchase is automatically applied at checkout. Offer excludes but is not limited to new products, travel sizes, boxed sets and bags. Offer cannot be combined with other discounts or applied to past or future purchases. Offers and promotions may be subject to additional terms and conditions. Additional exclusions may apply.
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Highly-potent serum with a silky, luxurious texture absorbs quickly to smooth the look of even the most stubborn, deep-set lines, wrinkles and creases around the mouth, eyes, lips and forehead, including marionette lines, frown lines, smile lines and nasolabial folds. Over time, these engraved imperfections appear shallower and expression lines appear erased, as the vitamin F blend works to replenish skin’s moisture barrier and protect it from environmental aggressors.
What It Does
- Softens the look of facial lines from daily repetitive movements.
- Visibly improves etched creases making them appear more shallow.
- Minimizes the appearance of skin imperfections and imparts a beautiful radiance.
What To Expect
Due to the science and compounds used in our products the feel and scent may vary.
Texture: Serum
Consistency: Lightweight
Scent: Natural, aromatic rose
* This product is free from soy, nuts, gluten, fish, milk, corn, phthalates, sulfates, parabens, talc, and mineral oil. Cruelty-free.
After cleansing, massage onto face and neck using a gentle upward motion. Wait until fully absorbed and follow with your favorite Perricone MD moisturizer. Use morning and evening.
Consumer Results
Overall Skin Condition:
93% noticed skin looked renewed*
84% saw that skin looked more toned*
Advanced Claims:
89% noticed an improvement in lines and texture*
86% felt firmer, tighter skin*
86% saw an improvement in expression lines*
84% saw that wrinkles were smoothed*
83% noticed creases appeared shallower and forehead lines appeared smoother*
82% saw tighter-looking skin*
80% saw lines smoothed around the mouth and lips*
79% noticed engraved imperfections appeared shallower*
77% noticed that skin looked lifted*
74% felt that skin looked dramatically younger*
73% saw that deep-set wrinkles, including marionette lines and nasolabial folds were smoothed*
*In a consumer study of 102 women after 28 days
Acyl-Glutathione: The Master Antioxidant
Comprised of 3 amino acids, glutathione is the body’s main antioxidant and as part of a comprehensive skincare regimen can help to reduce the look of wrinkles and creases by replenishing fragile skin. Natural levels of this essential building block deplete over time, but topical application can help skin appear smoother and more youthful.
Vitamin F Blend: Ultimate Moisture Barrier Protection
Flax, chia and macadamia seed oils work over time to restore suppleness and create a healthy glow by intensely moisturizing and improving skin’s moisture barrier. Essential, yet not naturally found in the human body.
Ingredients:
Water/Aqua/Eau, Propanediol, Squalane, Hydrogenated Polyisobutene, S-Palmitoylglutathione, Dimethicone, Glycerin, Macadamia Ternifolia Seed Oil, Xylitylglucoside, Tetrahexyldecyl Ascorbate, Dimethyl MEA, Palmitoyl Tripeptide-5, Acetyl Hexapeptide-8, Anhydroxylitol, Lactic Acid, Xylitol, Xanthan Gum, Linum Usitatissimum (Linseed) Seed Oil, Salvia Hispanica Seed Oil, Tocopherol, Ethylhexylglycerin, Magnesium Aspartate, Zinc Gluconate, Alaria Esculenta Extract, Glucose, Sodium Hyaluronate, Copper Gluconate, Tetradecyl Aminobutyroylvalylaminobutyric Urea Trifluoroacetate, Palmitoyl Dipeptide-5 Diaminobutyroyl Hydroxythreonine, Helianthus Annuus (Sunflower) Seed Oil, Rosmarinus Officinalis (Rosemary) Leaf Extract, Tetrasodium Glutamate Diacetate, Magnesium Chloride, Caprylic/Capric Triglyceride, Acrylates/C10-30 Alkyl Acrylate Crosspolymer, Caprylyl/Capryl Glucoside, Caprylyl Glycol, Potassium Sorbate, Phenoxyethanol, Fragrance/Parfum, Citronellol, Hydroxycitronellal, Limonene, Linalool
- Essential Fx Acyl-Glutathione
- Perricone MD
- 1 fl.oz / 30ml
Frequently Bought Together



Total Price: $310.00
Add both to cart