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Highly-potent serum with a silky, luxurious texture absorbs quickly to smooth the look of even the most stubborn, deep-set lines, wrinkles and creases around the mouth, eyes, lips and forehead, including marionette lines, frown lines, smile lines and nasolabial folds. Over time, these engraved imperfections appear shallower and expression lines appear erased, as the vitamin F blend works to replenish skin’s moisture barrier and protect it from environmental aggressors.
What It Does
- Softens the look of facial lines from daily repetitive movements.
- Visibly improves etched creases making them appear more shallow.
- Minimizes the appearance of skin imperfections and imparts a beautiful radiance.
What To Expect
Due to the science and compounds used in our products the feel and scent may vary.
Texture: Serum
Consistency: Lightweight
Scent: Natural, aromatic rose
* This product is free from soy, nuts, gluten, fish, milk, corn, phthalates, sulfates, parabens, talc, and mineral oil. Cruelty-free.
After cleansing, massage onto face and neck using a gentle upward motion. Wait until fully absorbed and follow with your favorite Perricone MD moisturizer. Use morning and evening.
Consumer Results
Overall Skin Condition:
93% noticed skin looked renewed*
84% saw that skin looked more toned*
Advanced Claims:
89% noticed an improvement in lines and texture*
86% felt firmer, tighter skin*
86% saw an improvement in expression lines*
84% saw that wrinkles were smoothed*
83% noticed creases appeared shallower and forehead lines appeared smoother*
82% saw tighter-looking skin*
80% saw lines smoothed around the mouth and lips*
79% noticed engraved imperfections appeared shallower*
77% noticed that skin looked lifted*
74% felt that skin looked dramatically younger*
73% saw that deep-set wrinkles, including marionette lines and nasolabial folds were smoothed*
*In a consumer study of 102 women after 28 days
Acyl-Glutathione: The Master Antioxidant
Comprised of 3 amino acids, glutathione is the body’s main antioxidant and as part of a comprehensive skincare regimen can help to reduce the look of wrinkles and creases by replenishing fragile skin. Natural levels of this essential building block deplete over time, but topical application can help skin appear smoother and more youthful.
Vitamin F Blend: Ultimate Moisture Barrier Protection
Flax, chia and macadamia seed oils work over time to restore suppleness and create a healthy glow by intensely moisturizing and improving skin’s moisture barrier. Essential, yet not naturally found in the human body.
Ingredients:
Water/Aqua/Eau, Propanediol, Squalane, Hydrogenated Polyisobutene, S-Palmitoylglutathione, Dimethicone, Glycerin, Macadamia Ternifolia Seed Oil, Xylitylglucoside, Tetrahexyldecyl Ascorbate, Dimethyl MEA, Palmitoyl Tripeptide-5, Acetyl Hexapeptide-8, Anhydroxylitol, Lactic Acid, Xylitol, Xanthan Gum, Linum Usitatissimum (Linseed) Seed Oil, Salvia Hispanica Seed Oil, Tocopherol, Ethylhexylglycerin, Magnesium Aspartate, Zinc Gluconate, Alaria Esculenta Extract, Glucose, Sodium Hyaluronate, Copper Gluconate, Tetradecyl Aminobutyroylvalylaminobutyric Urea Trifluoroacetate, Palmitoyl Dipeptide-5 Diaminobutyroyl Hydroxythreonine, Helianthus Annuus (Sunflower) Seed Oil, Rosmarinus Officinalis (Rosemary) Leaf Extract, Tetrasodium Glutamate Diacetate, Magnesium Chloride, Caprylic/Capric Triglyceride, Acrylates/C10-30 Alkyl Acrylate Crosspolymer, Caprylyl/Capryl Glucoside, Caprylyl Glycol, Potassium Sorbate, Phenoxyethanol, Fragrance/Parfum, Citronellol, Hydroxycitronellal, Limonene, Linalool
- Essential Fx Acyl-Glutathione
- Perricone MD
- 1 fl.oz / 30ml
Frequently Bought Together



Total Price: $310.00
Add both to cart
Essential Fx Acyl-Glutathione Deep Crease Serum
Highly-potent serum to improve the appearance of deep creases, marionette and lip lines.
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$185.00
In stock
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4 instalments of $46.25 with Klarna Learn more
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4 installments of $46.25 with afterpay Learn more
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4 installments of $46.25 with zip Learn more
SAVE 35% WITH CODE: EFXACYL
Offer Valid though 06/26/2023 11:59 p.m. Pacific Time or while supplies last. Offer cannot be combined with other discounts or applied to past or future purchases. Other restrictions, exclusions or terms may apply.
Offer Valid though 06/26/2023 11:59 p.m. Pacific Time or while supplies last. Offer cannot be combined with other discounts or applied to past or future purchases. Other restrictions, exclusions or terms may apply.
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Highly-potent serum with a silky, luxurious texture absorbs quickly to smooth the look of even the most stubborn, deep-set lines, wrinkles and creases around the mouth, eyes, lips and forehead, including marionette lines, frown lines, smile lines and nasolabial folds. Over time, these engraved imperfections appear shallower and expression lines appear erased, as the vitamin F blend works to replenish skin’s moisture barrier and protect it from environmental aggressors.
What It Does
- Softens the look of facial lines from daily repetitive movements.
- Visibly improves etched creases making them appear more shallow.
- Minimizes the appearance of skin imperfections and imparts a beautiful radiance.
What To Expect
Due to the science and compounds used in our products the feel and scent may vary.
Texture: Serum
Consistency: Lightweight
Scent: Natural, aromatic rose
* This product is free from soy, nuts, gluten, fish, milk, corn, phthalates, sulfates, parabens, talc, and mineral oil. Cruelty-free.
After cleansing, massage onto face and neck using a gentle upward motion. Wait until fully absorbed and follow with your favorite Perricone MD moisturizer. Use morning and evening.
Consumer Results
Overall Skin Condition:
93% noticed skin looked renewed*
84% saw that skin looked more toned*
Advanced Claims:
89% noticed an improvement in lines and texture*
86% felt firmer, tighter skin*
86% saw an improvement in expression lines*
84% saw that wrinkles were smoothed*
83% noticed creases appeared shallower and forehead lines appeared smoother*
82% saw tighter-looking skin*
80% saw lines smoothed around the mouth and lips*
79% noticed engraved imperfections appeared shallower*
77% noticed that skin looked lifted*
74% felt that skin looked dramatically younger*
73% saw that deep-set wrinkles, including marionette lines and nasolabial folds were smoothed*
*In a consumer study of 102 women after 28 days
Acyl-Glutathione: The Master Antioxidant
Comprised of 3 amino acids, glutathione is the body’s main antioxidant and as part of a comprehensive skincare regimen can help to reduce the look of wrinkles and creases by replenishing fragile skin. Natural levels of this essential building block deplete over time, but topical application can help skin appear smoother and more youthful.
Vitamin F Blend: Ultimate Moisture Barrier Protection
Flax, chia and macadamia seed oils work over time to restore suppleness and create a healthy glow by intensely moisturizing and improving skin’s moisture barrier. Essential, yet not naturally found in the human body.
Ingredients:
Water/Aqua/Eau, Propanediol, Squalane, Hydrogenated Polyisobutene, S-Palmitoylglutathione, Dimethicone, Glycerin, Macadamia Ternifolia Seed Oil, Xylitylglucoside, Tetrahexyldecyl Ascorbate, Dimethyl MEA, Palmitoyl Tripeptide-5, Acetyl Hexapeptide-8, Anhydroxylitol, Lactic Acid, Xylitol, Xanthan Gum, Linum Usitatissimum (Linseed) Seed Oil, Salvia Hispanica Seed Oil, Tocopherol, Ethylhexylglycerin, Magnesium Aspartate, Zinc Gluconate, Alaria Esculenta Extract, Glucose, Sodium Hyaluronate, Copper Gluconate, Tetradecyl Aminobutyroylvalylaminobutyric Urea Trifluoroacetate, Palmitoyl Dipeptide-5 Diaminobutyroyl Hydroxythreonine, Helianthus Annuus (Sunflower) Seed Oil, Rosmarinus Officinalis (Rosemary) Leaf Extract, Tetrasodium Glutamate Diacetate, Magnesium Chloride, Caprylic/Capric Triglyceride, Acrylates/C10-30 Alkyl Acrylate Crosspolymer, Caprylyl/Capryl Glucoside, Caprylyl Glycol, Potassium Sorbate, Phenoxyethanol, Fragrance/Parfum, Citronellol, Hydroxycitronellal, Limonene, Linalool
- Essential Fx Acyl-Glutathione
- Perricone MD
- 1 fl.oz / 30ml
Frequently Bought Together



Total Price: $310.00
Add both to cart
Customer Reviews
Top Customer Reviews
Where reviews refer to foods or cosmetic products, results may vary from person to person. Customer reviews are independent and do not represent the views of The Hut Group.
The best serum for deep wrinkles!
Perricone’s deep crease serum is one of my favorite skin care products. With regular use, it has substantially softened my deep wrinkles, especially my frown lines. I love this product and highly recommend it for smoothing deep facial creases.
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Definite difference
Significantly fewer creases on the side of eyes and along smile lines. Â For a while, I stopped using around my mouth and nose and more noticeable smile lines returned! Â Back in my regimen now!
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It Really Works!!
Perricone products are amazing. They truly do what they're designed to do. Price wise they're a little expensive but they have great sales. Well worth the money. Every time I place an order they send free samples with my order. Things I wouldn't normally order but after using the sample I'm usually placing an order. They work!!
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Awesome stuff
I use this in the morning and I swear it takes 10 yrs off
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not as expected
After reading the glowing reviews I purchased the deep crease serum. I really didn't see how it could act as liquid botox but I thought I'd give it a try. I used it twice a day as recommended on my marionette lines and my forehead H crease. Nothing, absolutely nothing. Might work better if you have wrinkles or creases that aren't as deep or long standing. Too late at my age (78) I think.
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how wonderful
I am skeptical of many facial fixes. Â I am amazed how this serum altered the depth of the lines around my lips . Â Bravo!!!!
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Deep crease serum
What a great product!! As are all Pericone products. I noticed right away on my forehead. Those nasty lines that crinkle up when you show expressions. You know what I mean lol. Adds 5 years just by laughing haha. A little goes a long way. I now have a botox looking forehead. Nice & smooth. I only have to use a tiny, & I mean a tiny bit. Absorbs relatively fast. Use around mouth and that good old line in the crease of neck. Use sparingly, along with other Pericone products and you'll look 10 years younger in only a couple weeks. But you do see results within a week. Another Pericone favorite!!
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Love this product
Works almost instantly. I was very surprised how the fine lines were remarkably less pronounced upon application. I highly recommend the product to anyone who wish to reduce fine lines & wrinkles.
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Yes. This product works
I found this product a few years ago and used it to great effect. Then it went out of stock for a long time and of course my creases deepened again. It's back! Buy it. For years I've had deep crease between my eyebrows(age 70).This product definitely softens the deep creases between my eyebrows and around my mouth.Â
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Youth in a Bottle
Run don’t walk.  This stuff is amazing and it works fast. I had very deep creases on my forehead. I won’t mention any names, but I had tried several high end products that did not work.  This product erased by finer creases with in three days and has significantly diminished the crater or a crease on my forehead. Very happy. Cannot live without!! Also the results don’t just disappear when you stop using the product.Â
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