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One jar that does it all. This multi-tasking powerhouse uses a proprietary liquid crystal delivery system for faster and deeper penetration of key ingredients into skin's surface. Targets and dramatically improves the feel and appearance of loss of radiance, uneven texture, uneven tone, discoloration, redness, enlarged pores, lines, wrinkles and loss of firmness.
What it Does
Advanced Serum Concentrate that promotes the 9 most visible signs of healthy, youthful-looking skin by targeting and improving the appearance of:
- Fine Lines
- Wrinkles
- Enlarged pores
- Dullness
- Uneven texture
- Uneven skin tone
- Discoloration
- Redness
- Loss of firmness
What to Expect
Texture: Serum Concentrate
Consistency: Lightweight, fast-absorbing
Scent: Fragrance-Free
*This product is free from nuts, gluten, fish, milk, corn, fragrance, phthalates, sulfates, parabens, talc, and mineral oil. Cruelty-free and 100% vegan.
Clinical Results
100% showed a significant improvement in fine lines and wrinkles*
97% showed a significant improvement in pore size*
*In a clinical study on 30 women over 28 days
Consumer Results
87% agreed that their skin appears more radiant**
87% agreed that the product visibly improves the texture of skin**>
83% agreed that the product evens skin tone**
81% agreed that they saw a reduction in the look of redness and blotchiness**
81% agreed that they noticed an improvement in skin discoloration**
79% felt firmer skin**
**In a consumer study with 52 women over 28 days
Build Your Regiment for Maximum Results:
- Cleanser: Nutritive Cleanser
- Toner: Intensive Pore Minimizing Toner
- Day Serum: Advanced Serum Concentrate,CBD Advanced Serum Concentrate
- Day Moisturizer: The Intensive Hydrating Complex
- Day Neck & Chest:Neck & chest Broad Spectrum SPF 25
- Night Serum: Advanced Serum Concentrate,CBD Advanced Serum Concentrate
- Night Moisturizer: The Intensive Hydrating Complex
- Night Neck & Chest: Sub-D/Neck
- Eye: Advanced Eye Cream
- Hand: Hand Therapy
- Body: Fragile Skin Therapy
Vitamin C Ester
Supercharged Brightening & Smoothing. A more potent, highly stable and less abrasive form of antioxidant powerhouse vitamin C, Vitamin C Ester gives the appearance of collagen-rich skin by smoothing, brightening and minimizing the look of discoloration over time. Unlike traditional vitamin C, Vitamin C Ester is fat-soluble and easily absorbable for maximum antioxidant benefits.
Omegas 3, 6, and 9
Essential Moisture Barrier Protection. Found in walnuts and flax seeds, these pro-fatty acids help visibly plump and increase radiance over time by strengthening skin’s moisture barrier and improving its ability to retain water. Omegas 3 & 6 are essential yet do not occur naturally in the body.
Copper Tripeptide
Refresh & Rejuvenate. A powerful, naturally occurring complex with three amino acids helps repair dry skin for a dramatically firmer, smoother, younger-looking complexion. This amino acid trio is highly absorb-able and helps protect against environmental aggressors.
Ingredients
Water/Aqua/Eau, Isopropyl Palmitate, Glycerin, Cetearyl Alcohol, Glyceryl Stearate, PEG-100 Stearate, Butylene Glycol, Phosphatidylcholine, Tetrahexyldecyl Ascorbate, Dimethyl MEA, Acetyl Hexapeptide-8, Palmitoyl Tripeptide-1, Palmitoyl Tetrapeptide-7, Tyrosine, Echium Plantagineum Seed Oil, Glycolic Acid, Hydrolyzed Myrtus Communis Leaf Extract, Copper Tripeptide-1, Helianthus Annuus (Sunflower) Seed Oil, Magnesium Aspartate, Zinc Gluconate, Copper Gluconate, Ethylhexylglycerin, Rosmarinus Officinalis (Rosemary) Leaf Extract, Sodium Hyaluronate, Retinyl Palmitate, Disodium EDTA, Carbomer, Ceteareth-20, Hydrogenated Vegetable Glycerides, Dimethicone, Caprylyl Glycol, Polysorbate 20, Phenoxyethanol, Sorbic Acid, Potassium Sorbate
After cleansing, massage onto face and neck using a gentle upward motion. Wait until fully absorbed and follow with your favorite Perricone MD moisturizer. Use mornings and evenings.
Order of Application:
For best results, follow the order of product application below.
- Cleanser
- Toner
- Day Serum
- Day Moisturizer
- Day Neck & Chest
- Night Serum
- Night Moisturizer
- Night Neck & Chest
- Eye
- Mask
- Hand
- Body
Cold Plasma Plus+ Advanced Serum Concentrate
This advanced serum concentrate promotes the 9 most visible signs of healthy, youthful-looking skin.
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$149.00
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4 installments of $37.25 with afterpay Learn more
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4 installments of $37.25 with sezzle Learn more
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4 installments of $37.25 with zip Learn more

GIFT WITH PURCHASE WITH CODE: CPPSUMMER
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Offers and promotions may be subject to additional terms and conditions.
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One jar that does it all. This multi-tasking powerhouse uses a proprietary liquid crystal delivery system for faster and deeper penetration of key ingredients into skin's surface. Targets and dramatically improves the feel and appearance of loss of radiance, uneven texture, uneven tone, discoloration, redness, enlarged pores, lines, wrinkles and loss of firmness.
What it Does
Advanced Serum Concentrate that promotes the 9 most visible signs of healthy, youthful-looking skin by targeting and improving the appearance of:
- Fine Lines
- Wrinkles
- Enlarged pores
- Dullness
- Uneven texture
- Uneven skin tone
- Discoloration
- Redness
- Loss of firmness
What to Expect
Texture: Serum Concentrate
Consistency: Lightweight, fast-absorbing
Scent: Fragrance-Free
*This product is free from nuts, gluten, fish, milk, corn, fragrance, phthalates, sulfates, parabens, talc, and mineral oil. Cruelty-free and 100% vegan.
Clinical Results
100% showed a significant improvement in fine lines and wrinkles*
97% showed a significant improvement in pore size*
*In a clinical study on 30 women over 28 days
Consumer Results
87% agreed that their skin appears more radiant**
87% agreed that the product visibly improves the texture of skin**>
83% agreed that the product evens skin tone**
81% agreed that they saw a reduction in the look of redness and blotchiness**
81% agreed that they noticed an improvement in skin discoloration**
79% felt firmer skin**
**In a consumer study with 52 women over 28 days
Build Your Regiment for Maximum Results:
- Cleanser: Nutritive Cleanser
- Toner: Intensive Pore Minimizing Toner
- Day Serum: Advanced Serum Concentrate,CBD Advanced Serum Concentrate
- Day Moisturizer: The Intensive Hydrating Complex
- Day Neck & Chest:Neck & chest Broad Spectrum SPF 25
- Night Serum: Advanced Serum Concentrate,CBD Advanced Serum Concentrate
- Night Moisturizer: The Intensive Hydrating Complex
- Night Neck & Chest: Sub-D/Neck
- Eye: Advanced Eye Cream
- Hand: Hand Therapy
- Body: Fragile Skin Therapy
Vitamin C Ester
Supercharged Brightening & Smoothing. A more potent, highly stable and less abrasive form of antioxidant powerhouse vitamin C, Vitamin C Ester gives the appearance of collagen-rich skin by smoothing, brightening and minimizing the look of discoloration over time. Unlike traditional vitamin C, Vitamin C Ester is fat-soluble and easily absorbable for maximum antioxidant benefits.
Omegas 3, 6, and 9
Essential Moisture Barrier Protection. Found in walnuts and flax seeds, these pro-fatty acids help visibly plump and increase radiance over time by strengthening skin’s moisture barrier and improving its ability to retain water. Omegas 3 & 6 are essential yet do not occur naturally in the body.
Copper Tripeptide
Refresh & Rejuvenate. A powerful, naturally occurring complex with three amino acids helps repair dry skin for a dramatically firmer, smoother, younger-looking complexion. This amino acid trio is highly absorb-able and helps protect against environmental aggressors.
Ingredients
Water/Aqua/Eau, Isopropyl Palmitate, Glycerin, Cetearyl Alcohol, Glyceryl Stearate, PEG-100 Stearate, Butylene Glycol, Phosphatidylcholine, Tetrahexyldecyl Ascorbate, Dimethyl MEA, Acetyl Hexapeptide-8, Palmitoyl Tripeptide-1, Palmitoyl Tetrapeptide-7, Tyrosine, Echium Plantagineum Seed Oil, Glycolic Acid, Hydrolyzed Myrtus Communis Leaf Extract, Copper Tripeptide-1, Helianthus Annuus (Sunflower) Seed Oil, Magnesium Aspartate, Zinc Gluconate, Copper Gluconate, Ethylhexylglycerin, Rosmarinus Officinalis (Rosemary) Leaf Extract, Sodium Hyaluronate, Retinyl Palmitate, Disodium EDTA, Carbomer, Ceteareth-20, Hydrogenated Vegetable Glycerides, Dimethicone, Caprylyl Glycol, Polysorbate 20, Phenoxyethanol, Sorbic Acid, Potassium Sorbate
After cleansing, massage onto face and neck using a gentle upward motion. Wait until fully absorbed and follow with your favorite Perricone MD moisturizer. Use mornings and evenings.
Order of Application:
For best results, follow the order of product application below.
- Cleanser
- Toner
- Day Serum
- Day Moisturizer
- Day Neck & Chest
- Night Serum
- Night Moisturizer
- Night Neck & Chest
- Eye
- Mask
- Hand
- Body
Customer Reviews
Top Customer Reviews
Where reviews refer to foods or cosmetic products, results may vary from person to person. Customer reviews are independent and do not represent the views of The Hut Group.
The Best!
I have been using Perricone products since you young twenties, and I’m now 53! I constantly have people comment on my skin… I even had 2nd and 3rd degree burns on my face when I was 2 years old. There is no product line I feel that even comes close to Perricone products! I’ve tried more expensive lines and always come back to Perricone… and the Cold Plasma Plus  is my favorite product by far! The growth factor line is pretty great as well… My close friends and acquaintances often say they feel it’s genetics as to why my skin looks so great, but that’s not why my skin looks so great… it’s over 25 years of using Perricone! My older sister’s skin is proof… she later in life took my advice and after 2 years her skin had dramatically changed! I will say sunscreen usage in my later 20’s to now has helped… but Perricone is the main reason my face looks as great as it does!!! I can’t tell you how many people have said I should be their poster child or advertisement…
Report this reviewFabulous products
I love the cold plasma line of products. They firm my skin and help lesson my fine lines and wrinkles. I have added the cold plasma intensive hydrating creme and it works great as well.Â
Report this reviewCold Plasma Plus+ Advance Serum concentrate
Just wanted to say I LOVE this product. I have been using the Cold Plasma product for quite a while and I am sold on the Cold Plasma Plus+ Advance Serum concentrate. I love the way it goes on, sinks right in, smells wonderful. I use both morning and night prior to using any moisturizer. It's the best!! Wouldn't be without it!!
Report this reviewCold Plasma Plus Advanced Serum
I love all the Perricone products. The serum is wonderful to even out skin tone , A little goes a long way and I can definitely see a difference when I don’t use the serum.
Report this reviewGlad I decided to try
I’ve been using Perricone MD for a couple of years now. I’ve tried the neuropeptide line which I love but ran out of. I decided to try the Cold Plasma + Advanced Serum Concentrate when they ran Black Friday promotions. I use the Cold Plasma Eye Cream and like it- so I figured why not try the serum too? It goes on smooth and doesn’t smell like anything. I’m not in love with the pump bottle- the pump sometimes gets stuck in one position or sometimes too much product comes out- but that’s not a huge deal. As with all Perricone MD products, a little goes a long way. I use this on my face and neck as directed and use the rest on the backs of my hands. I’m turning 57 next month and no one can guess my age- I usually get early 40s!! I’ll keep using Perricone MD- I really do see results.Â
Report this reviewSmall but far-reaching changes
I bought 2 pieces of larger one (149ml each) 2 weeks before with nice discount which I just found it is out of stock right now. I started to apply it while after shower. Instead of saying it is a cold cream, I would say it is a concentration. After applying it to the hand first, it is going to turn white like the cream and then I had a small rub treat with face. It's not greasy at all, it gets absorbed quickly. I first treated my face with the tonic water and then used perricond's lipidated vitamin C. The name seems to be CCC. Then I applied this essence. According to online reviews, the old version is a bit fishy, but this one has almost no taste, maybe It is a new version. You can score 85 points on the face for the first time. In summary, it is not irritating, tasteless, and has a good moisturizing effect. The anti-aging effect remains to be seen. Some people will treat it as a cream, but it is not enough to be a cream, and it needs to be superimposed. Oily creams will work better.
Report this reviewWorth it!
I like how it feels on my skin. Â I've been using it for years and I think it slows down my skin's aging. Â Everyone thinks I look younger than my age.Â
Report this reviewExcellent
I have been using Dr Perricone products for some time now! I tried many many other products but I always come back to Perricone
Report this reviewGreat Product
I've been using Cold Plasma Plus products for quite a few years now and very pleased with the results, will keep buying again and again.
Report this reviewStill look years younger
I started using the Cold Plasma about 5 years ago daily as a moisturizer and my skin has no wrinkles and I’m about to turn 36, I live in a city, have batted acne, have a Hugh stress job and still this product hands me youth on a platter. I love it and I use it everyday.Â
Report this review