Thio:Plex Intensive 2-Step Brightening System

Thio:Plex Intensive 2-Step Brightening System - Perricone MD
  • Thio:Plex Intensive 2-Step Brightening System


Thio:Plex Intensive 2-Step Brightening System - Perricone MD
Unprecedented potency yields unparalleled results. This innovative 2-step treatment uses highly concentrated and advanced ingredients to deliver a unique combination of anti-aging and skin brightening benefits. Read More
$49.97 44.97
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Additional Information

Product Details

What It Is

This unique two-step product offers a combination of skin brightening, discoloration reducing, and lifting and tightening benefits that is rarely available in a single product. Intensive Base (Step 1) contains unprecedented levels of Thio Antioxidant, the body’s master detoxification and repair agent. Brightening Activator (Step 2) contains high levels of our proprietary Vitamin Complex, a powerful antioxidant, which works synergistically with Intensive Base to further fight discoloration.

What It Does
  • Transforms skin overnight to reveal visibly brighter, tighter-looking skin
  • Minimizes the appearance of skin discoloration for a more evened skin tone
  • Visibly renews skin unveiling dramatic, younger-looking skin
What To Expect

Due to the science and compounds used in our products the feel and scent may vary.






May have a strong scent, but should dissipate after application

Consumer Results

93% said their skin appeared firmer, brighter & more youthful

97% said their skin looked smoother

97% said they saw an improvement in the dullness of their skin


Vitamin C Ester: Supercharged Brightening & Smoothing

A more potent, highly stable and less irritating form of antioxidant-rich Vitamin C, Vitamin C Ester gives the appearance of collagen-rich skin by visibly smoothing, brightening and minimizing discoloration over time. Unlike traditional Vitamin C, Vitamin C Ester is fat-soluble and easily absorbable for maximum antioxidant benefits.


Step 1 - Intensive Base

Water/Aqua/Eau, Glutathione, Kaolin, Magnesium, Aluminum Silcate, Aluminum Chlorohydrate, Disodium EDTA, Fragrance/Parfum, Glyceryl Stearate, Alcohol Denat., Dimethyl MEA, Phosphatidylcholine, Thioctic Acid, Ascorbyl Palmitate, Ascorbyl Glucoside, Glycolic Acid, Xanthan Gum, Camellia Sinensis Leaf Extract, Colloidal Silver (Nano), PEG/PPG-18/18 Dimethicone, Caprylyl Glycol, Glycerin, Phenoxyethanol, Sorbic Acid, Limonene.

Step 2 - Brightening Activator

Water/Aqua/Eau, Ascorbyl Palmitate, Isoprobyl Palmitate, Cetearyl Alcohol, Glyceryl Stearate, PEG-100 Stearate, Tocotrienols, Tocopherol, Sodium Hyaluronate Disodium EDTA, Ceteareth-20, Dimethicone, Cyclopentasiloxane, Caprylyl Glycol, Cyclohexasiloxane, Zinc Sulfate, Elaeis Guineensis (Palm) Oil, Phenoxyethanol, Sorbic Acid, Fragrance/Parfum, Limonene, Linalool, Citral.



In the evening, Dr. Perricone recommends applying a pea-sized amount of Step 1 – Intensive Base onto a cleansed face. Wait a few moments until product is completely dry and layer with a pea-sized amount of Step 2 – Brightening Activator.

Application Process




Pea-sized Amount


1x / Day in the evening


8 Weeks

  1. Cleanse skin in the evening using your favorite Perricone MD Cleanser.
  2. Next, apply a pea-sized amount of Step 1 - Intensive Base.
  3. Wait a few moments until product is dry and layer a pea-sized amount of Step 2 - Brightening Activator onto face.
  4. Leave on for 20 minutes and rinse off with warm water.
  5. For additional benefits, reapply both steps on particularly noticeable areas of discoloration as a spot treatment. May also be left on overnight.


I just received this and it smells like hair perming solution. Is that normal?


Yes; Thio:Plex (step one part) has a medicinal scent due to the natural ingredients. Allow it to dry before applying step two and the scent should dissipate.


How does the thio brightening complex differ from the vitamin c Ester nightly regimen? Also, can you tell me how the firming facial toner differs from the intensive pore treatment? I'm just purchased the cold plasma plus set and am wondering if it negates the need for any of these?


Cold Plasma Plus enhances and pairs well with these treatments. The toner is a liquid treatment that you wipe the skin with, and the Intensive Pore Treatment is a lotion that you leave on. Thio:Plex was developed for cases of uneven skin tone such as melasma and hyperpigmentation whereas the Vitamin C Ester 15 is for all brightening and firming concerns.





Dark spots almost gone


At night I wash my face and tone, then I apply Thio:Plex #1 on spots. Let dry then apply #2, then I use Cold Plasma then moisturizer. I've been using it for a month and noticed that my spots are getting lighter. I really like it a lot!

Do the Hairdo

El Sobrante


Amazing Results


I use Thio Plex about once every 3 months




Still on the 1st set of treatments


I use this product every evening before bed to try to get ride of age spots on my face. It has only been 2 weeks, I have only noticed a slight lighting of the areas, hopefully in 8 weeks they will be significantly lighter. I am a faithful Perricone user so I will keep my fingers crossed. There has been no peeling or irritation from the product



hope worth the smell


I have been using this product for about 2 weeks - not daily. Smell is pretty horrible. Was assured when I called in that it wasn't rancid so decided to suck it up and use it. Seems to be brightening up skin but still a bit early to tell.

Auntie B

Portland, OR

Love It!!


Does as promised. After using my face feels smooth, detoxed, and looks like I exfoliated it. Prolonged use has resulted in my skin being smoother and firmer. Yes smell is strong but as long as a product works I don't care. Beauty does not come without a cost and the smell is a small price to pay. =-)


Huntington Beach, CA


Good at lightening spots and brightening skin


So far, no miracles. Good over all. I hope with continued use to see my age spots diminish.


Redlands, CA


Such an amazing product


I have tried so many products to help with the dark spots on my face and hands. I have found the product for me! I tried this on a steals and deals segment on GMA. My results are truly amazing. I wanted to reorder so I clicked a link on the GMA site and sent an email that said "please send me deal info" to my surprise I received an email back with 24 hours....from Kelly a Perricone representative! Thank you Kelly you were so helpful. I get facials 3+ times a year on my last visit the improvement in my discoloration. I have family members commenting on how nice my skin looks. I recommend this product to everyone and hope this works as well for you. Will be a staple in my skin care regiment.






This product smells horrible, I applied it on my face and I couldn't stand the smell I had to wash it right away the smell gave me a headache I almost vomited


Tutin, Ca


Sorry, no results


No change whatsoever and it clogged the pores on my nose. So expensive; can't just toss in the trash. Will try some spot targeting age mask area under eyes on cheekbones only. Coupled with the smell, I can't recommend.


Boston, MA


Good product but no customer care


Tried the product - it does brighten. My skin requires a lot of additional moisture once I started using the product. Am giving three starts only because the customer care never answered my question if it's ok to use this product during pregnancy. If i get an answer from them, I'll improve the rating.




Thio:Plex Intensive 2-Step Brightening System

3.7 13


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