(146) Read Reviews
Acyl-Glutathione - Perricone MD
  • Acyl-Glutathione


Acyl-Glutathione - Perricone MD
(146) Read Reviews
Formulated with Dr. Perricone’s patented Acyl-Glutathione, this treatment is specifically designed to minimize the look of creases while improving the appearance of thinner, more fragile-looking skin texture for overall visibly younger skin. Read More
$185.00 166.50
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Additional Information

Product Details

What It Is

Formulated with Dr. Perricone’s patented Acyl-Glutathione, this treatment is specifically designed to minimize the look of lines and creases while improving the appearance of thinner, more fragile-looking skin texture for overall visibly younger skin.

What It Does
  • Diminishes the look of creases along targeted areas of the face.
  • Enhances the appearance of skin's elasticity and resilience.
  • Visibly improves fragile skin texture while imparting the radiance of youthful skin.
What To Expect

Due to the science and compounds used in our products the feel and scent may vary.






Natural, Aromatic


DMAE: Instant Firming

Naturally produced by the human brain, DMAE helps visibly lift sagging skin over time. Easily and quickly absorbed, it visibly plumps skin to help support skin's surface and protect against drying environmental aggressors.

Acyl-Glutathione: The Master Antioxidant

Comprised of three amino acids, Glutathione is the body's main antioxidant and helps to reduce the look of deep creases and improve fragile skinby protecting, repairing and detoxifying. Fat-soluble for maximum stability and penetration.


Aqua (Water), Isopropyl Palmitate, Tetrahexyldecyl Ascorbate, Cetearyl Alcohol, Phosphatidylcholine, S-Palmitoylglutathione, L-Tyrosine, Dimethyl MEA (DMAE), Glyceryl Stearate, PEG-100 Stearate, Ceteareth-20, Glycolic Acid, Oligopeptide-17, Oligopeptide-49, Squalane, Butyrospermum Parkii (Shea) Butter, Limnanthes Alba (Meadowfoam) Seed Oil, Docosahexaenoic Acid, Dimethicone, Sesamum Indicum (Sesame) Seed Oil, Glycerin, Magnesium Aspartate, Zinc Gluconate, Phenoxyethanol, Caprylyl Glycol, Parfum (Fragrance), Propylene Glycol, Disodium EDTA, Hydrolyzed Glycosaminoglycans, Elaeis Guineensis (Palm) Oil, Citric Acid, Tocotrienols, Copper Gluconate, Sorbic Acid, Tocopherol, Ascorbyl Palmitate, Thioctic Acid (Alpha-Lipoic Acid), Linalool



Dr. Perricone recommends massaging onto a cleansed face and neck in the evening. Follow with a Perricone MD moisturizer.

Application Process


Face and Neck


Pearl-Sized Amount


1x / Day


8 Weeks

  1. Dispense pearl-sized amount onto fingertips.
  2. Smooth onto face, paying special attention to visible expression lines and creases.
  3. Use in the evening.
  4. Follow with a Perricone MD moisturizer.


Can I stop auto delivery and how do I do it if I need to do this?


Yes; log into your account on the website, click manage auto delivery, and follow the easy-to-understand prompts and you can cancel your auto delivery plan.


This says it is for the face and neck, but you describe the application for around the eyes; the application is wrong on your website.


Great feedback. Thank you for bring to our attention. You are right the applications steps 1-5 are incorrect. I will mention this to corporate. Thank you

Perricone MD Skincare Specialist

My a.m. face routine - intensive pore minimizer, blue plasma, cold plasma,high potency face lift and FF moisturizer. My p.m. face routine - serum prep, cold plasma, high potency evening repair and FF moisturizer. Would the AG cream be good to add to this routine, and if so at what step in the routines? Should it replace any of the products I currently use? Should this be applied to the whole face or just problem areas? Thank you!


Acyl-Glutathione is a phenomenal treatment that addresses the following concerns:• Severe skin dryness • Deeper set lines and wrinkles especially on targeted areas of the face • Thinner, more fragile looking skin • Extreme loss of elasticity leading to visible sagging appearance • Lack of energy and vitality on the skin leading to dullness If these are your concerns I recommend adding to your current regime. This treatment should be applied after the Cold Plasma both in the AM &PM, follow with other Perricone products and moisturizer is always last. Have a nice day!

Perricone MD Skincare Specialist

How do you use it? How do you put it on?

The youn 58 year old.

Dr. Perricone recommends first warming up a small amount of product between your hands to facilitate spread over the entire face. Slide the pads of the fingers from the center of the eyebrows towards the outside of the forehead. Then with the palms of the hand proceed over temples, cheekbones and sides of nose in a gentle patting motion. End by sweeping upwards from the neck to the chin and jawline. Apply morning and evening after make-up removal on well cleansed skin.

Perricone MD Skincare Specialist

Hi. I'm 41 and starting to deal with 11 wrinkles, creases along the forehead and laughter lines. I recently bought the complete acyl-glutathione line (both serums and the AG). I also use Formula 15, Vitamin C Ester. What would be the best way to combine them for optimal and fast results? Should I alternate them? Thank you.


It is not necessary to use both the Formula 15 and Acyl-Glutathione Cream in the AM; so I recommend alternating. Since Formula 15 is an AM treatment use the serum, then the Formula 15 and a moisturizer is always applied last. In the PM apply Acyl-Glutathione Deep Crease Serum, Vitamin C Ester 15, Acyl-Glutathione Cream and moisturizer last. I hope this is helpful.

Perricone MD Skincare Specialist

what is the expiry date for this


All of Dr. Perricone's products have a 2 year shelf life.

Perricone MD Customer Care

do you use this at night on top of c-ester and or 15 or under. I uses them every other night and ovm in the morning


The Vitamin C Ester 15 is a night time serum and should be applied after cleansing, then apply the Acyl-Glutathione and a moisturizer is always recommended last. If you are using an AM treatment that contains the vitamin c ester, such as the High Potency Amine Complex Face Lift, the Acyl-Glutathione is applied first then the HP Amine and a moisturizer last.

Perricone MD Skincare Specialist

Received for a gift the cold plasma and the acrylic glutathione and I am not sure how to use or when. Can you assist me?


Thank you for contacting Perricone MD. The Cold Plasma is always the very first treatment applied after cleansing and using either a serum or toner; then follow with the Acyl-Glutathione and Dr. Perricone recommends applying a moisturizer last over treatments; this should be done both AM and PM. I hope this is helpful.

Perricone MD Skincare Specialist

Do I have to wait to apply acyl-glutathione after co;d plasma or do I aply immediately after cold plasma? Does photo plasma go right on after or again do I have to wait a bit and let the other absorb?


Dr. Perricone's products absorb very quickly into the skin and it is not necessary to wait in between applications; the Acyl-Glutathione can be applied immediately after Cold Plasma. Photo Plasma is a moisturizer and it is always applied last. I hope this is helpful.

Perricone MD Skincare Specialist

It can be used alone without a humidifier cream?


The Acyl-Glutathione is considered a treatment so you would use a moisturizer after applying this product.

Perricone MD Customer Care




Positive so far


I am 66 years old and have sensitive, fair, very dry skin with wrinkles around my lips and nose and sagging jaw line and some enlarged pores. I have been using this product along with precision reserve, blur, and no makeup foundation for about 2 weeks. I am very happy with some minimizing of the wrinkles and more youthful appearance of my skin. I recommend them for mature (old) skin and hope to be able to continue to use them in the future. Because I am using several products together, I can't objectively review them individually. Perhaps, they work well together. Con is that the products are very expensive. I was able to take advantage of a good sale and I will be looking for price reductions in the future.


Philadelphia, PA


I like this product very much.


I have been using this for a couple years now, ever since I noticed lines developing around my mouth. At first I used it just around my mouth, but then started using it everywhere when I noticed wrinkles on my cheeks. People tell me my skin looks so good, that I don't look anywhere near my age of 74. My philosophy is to invest in good skin care products so that my skin looks naturally good, rather than trying to cover up problems with makeup. Actually, I don't wear any makeup other than lipstick.




I would absolutely buy this product again


I put this product on after OVM serum in the evening and before applying Face finishing moisturiser. It is a beautiful product that glides on the skin addressing fine line and texture. I have been using for a little over two weeks and I have noticed a difference already.




I would buy this product again.


Better results than deep crease serum.


Santa Ana, CA


Love this product!!


This product is light and feels great on my skin. I saw noticeable improvement in fine lines within the first week. It doesn't have any strong scent and just glides over my face easily. This is my new "can't live without" Perricone product!


Omaha, NE


Love it!


I've been using the product for the weeks now and I'm getting complements on my skin again! I could see the difference after two days use. The lines in my forehead are barely noticeable and the sun spots on my cheeks and brow are gone. I'm amazed at how well this product has worked for me.


Upstate NY


Great product!


I highly recommend this product for sensitive skin. It has even helped my rosacea condition


Elmsford, NY


Love, love, love Acy-Glutathion


This product took 15 years off my face. At 72 my young students think I look younger than their 50+ grandmothers.


Minnetrista, Minnesota




I use every morning and I m amazed at the results


Hollywood, fl


Love This Product!!!


Love this product! Easy to use and results are easily seen!

Judy the Nana

Martinsburg WV



4.5 146


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