Firming Moisturizer

Firming Moisturizer - Perricone MD
  • Firming Moisturizer
  • Firming Moisturizer
  • Firming Moisturizer
  • Firming Moisturizer
  • Firming Moisturizer


Firming Moisturizer - Perricone MD
A luxurious, ultra-powerful formula provides essential, all-day hydration and helps dramatically and visibly firm thin and sagging skin on face. Read More
$290.00 261.00
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Product Details

What It Is

For the best hyaluronic acid moisturizer, Neuropeptide Firming Moisturizer is formulated with neuropeptides to visibly correct wrinkles, sagging and discoloration; DMAE to visibly lift saggy skin; and hyaluronic acid for essential hydration.

Thin skin is quenched for a visibly plumper appearance. For optimal results, apply after your favorite Perricone MD serum or facial cream.

What It Does
  • Delivers deep moisture for youthful-looking skin.
  • Corrects the appearance of wrinkles and imperfections.
  • Minimizes the appearance of loose, sagging skin.
What To Expect

Due to the science and compounds used in our products the feel and scent may vary.




Luxurious & Rich




DMAE: Instant Firming

Naturally produced by the human brain, DMAE helps visibly lift sagging skin over time. Easily and quickly absorbed, it visibly plumps skin to help support skin's surface and protect against drying environmental aggressors.

Neuropeptides: Uniting Surface Cells to Fight Wrinkles

Powerful, protein-like building blocks offer the ultimate visible antidote to wrinkles, sagging, dullness, and discoloration. Neuropeptides encourage surface skin cells to work together via a unique chemical structure.

Glycolic Acid: Superior Exfoliation

An ultra-powerful alpha hydroxy acid (AHA) instantly exfoliates, hydrates, and visibly reduces discoloration. A low molecular weight enables it to penetrate deep into skin's surface where it acts as a highly effective alternative to harsh physical exfoliants.


Water/Aqua/Eau, Isopropyl Palmitate, Cetearyl Alcohol, Taurine, Tyrosine, Glyceryl Stearate, PEG-100 Stearate, Ceteareth-20, Phosphatidylcholine, Dimethyl MEA, Acetyl Hexapeptide-8, Sodium Hyaluronate, Disodium EDTA, Dimethicone, Caprylyl Glycol, Phenoxyethanol, Sorbic Acid, Potassium Sorbate, Fragrance/Parfum, Citral, Citronellol, Geraniol, Hydroxycitronellal, Linalool.



Massage onto cleansed face and neck using a gentle upward motion. Use morning and evening. For best results, apply after your favorite Perricone MD serum, serum concentrate or facial cream.


What color is the product supposed to be. I recently bought one that is bright white. The last one was more of an ivory color. Is this normal?


Due to the science and natural compounds used in our products the color may vary slightly from batch to batch. This is normal.


In what order should I use the Neuropeptide Firming Moisturizer and the Neuropeptide Facial Cream? Can I use my own moisturizer before the NFM without altering its effectiveness? (I find the NFM somewhat drying. Is that just an indication that it's working?)

Longtime Perricone fan

Thank you for contacting Perricone MD. There are five steps to following the Perricone regime and they are: 1a. Cleanser 1b. Treatment Mask 2. Toner or Serum 3. Exfoliant 4. Treatment 5. Moisturizer The Neuropeptide Facial Cream (STEP 4) is a treatment and should be applied first and the Neuropeptide Firming Moisturizer (STEP 5) is a moisturizer and it should always follow last. Have a nice day!

Perricone MD Customer Care Specialist

Add Chia Serum (Perricone MD) to the neuropepetide firming moisturizer for added moisture and brightness


is this product gluten free and sulfate free?


Thank you for contacting Perricone MD. All of Dr. Perricone's topical products are sulfate & gluten free except for the Face Finishing Moisturizer, No Foundation Foundation. Our supplements are all gluten free. I hope this is helpful.

Perricone MD Skincare Specialist

I use Retin A at night, does the Neuropeptide moisturizer work well with the Retin A ?


Thank you for contacting Perricone MD. Yes, the Neuropeptide Firming Moisturizer is an excellent moisturizer to apply after you Retin A. I hope this is helpful.

Perricone MD Skincare Specialist

For what type of skin it's for? Dry? Normal? I understood about lines etc, still didn't get will it work for very dry and dehydrated skin.


Thank you for contacting Perricone MD. The Neuropeptide Firming Moisturizer is recommended for our clients in the advanced stages of aging, that have a lot of crepiness and sagging loose skin. If this is not your concern and you are in need of a moisturizer for dry skin I recommend either the Deep Moisture Therapy or the Hypoallergenic Nourishing Moisturizer; they are both excellent moisturizers for dry skin. I hope this is helpful.

Perricone MD Skincare Specialist

Hello I purchased a bundle from QVC. It came with the Nutritive Cleanser, Neuropeptide Night Cream, Face Finishing Moisturizer, Neuropeptide Necolletage and the Cold Plasma Eye. I am 29 years old. Do you recommend I use all the products? If so what product do I apply first? I have real oily skin. Thank you.


Hello, the way in which you will apply your products is as follows. AM: Nutritive Cleanser, Cold Plasma Eye (eye area only) Face Finishing Moisturizer, Neuropeptide Necolletage. PM: Nutritive Cleanser, Cold Plasma Eye, Neuropeptide Night Cream, Neuropeptide Necolletage.

Is it free shipping?


Perricone MD offers free shipping with your purchase of $50 or more.

Perricone MD Customer Care

Can I use this product instead of High Potency Amine Face Lift and High Potency Evening Repair? I have noticed that retinol is drying to my skin and I am searching for something else. I am 64 years old, and have used Perricone products since my late 40's with great success. Face finishing moisturizer used to do it for me, but I think I need more now as I have aged. I would like to limit my routine to 2 or 3 products that would help me most. I have noticed lines and sagging around my mouth and lower facial area as well as enlarged pores. Thanks for your answer as this will be quite an investment for one product. Where does cold plasma fit into the routine or does it?

Retired and new Grandma

Thank you for contacting Perricone MD. The Neuropeptide Firming Moisturizer is a moisturizer and not a replacement for the High Potency treatments. However, this moisturizer can be applied over the High Potency Treatments and this will eliminate the dryness you've been experiencing. Here is what I recommend for the lines and creases: Acyl-Glutathione is a phenomenal treatment that addresses "accelerated signs of aging." The accelerated signs of aging driven by hormonal changes and stress are universally characterized by: • Helps to minimize the appearance of lines and creases. • Visibly improves the look of skin texture. • Improves the level of moisture leaving skin feeling more supple and resilient. • Addresses dryness and diminishes the look of enlarged pores. This patent pending formula dramatically reduces the appearance of creases and other signs of skin aging. This is an AM and PM treatment and a moisturizer should follow. I hope this is helpful. Happy Holidays!

Perricone MD Skincare Specialist

What is the difference between neuropeptide firming moisturizer and neuropeptide night cream?


Thank you for contacting Perricone MD. The Neuropeptide Night Cream is a treatment that addresses loss of elasticity, diminishes fine lines, wrinkles and creases as well as firming the skin. The Neuropeptide Firming Moisturizer is an (AM & PM) moisturizer that is always applied last over the treatments. I hope this is helpful. Happy Holidays!

Perricone MD Skincare Specialist

I'm presently using Cold Plasma, DMAE Amine Face lift and Cold Plasma Sub D during the day. From the reviews it sounds like the Neuropeptide Firming Moisturizer may be a way for me to eliminate some of these products. Would the Neuropeptide take the place of all three?


Thank you for contacting Perricone MD. The Neuropeptide Firming Moisturizer is a moisturizer, not a treatment and it does not replace any of the treatments you are currently using. However, you are missing the final step in your current regime which is a moisturizer. I recommend adding the Neuropeptide Firming Moisturizer; which can be applied last over your treatments both AM and PM. I hope this is helpful.

Perricone MD Skincare Specialist




Terrific product


I use this product with cold plasma face. My skin looks firmer and brighter. My pores seem reduced and my makeup looks smooth. Overall, my skin seems more youthful and friends have commented. I happily share, it's Perricone products!


Titusville, Florida




I used morn and night for about a week and had extreme drying around eye orbital area. Have been using cold plasma plus and love it.


Oregon coast


Yes I would buy this product again.


Great and creamy and goes on easy ...very Rich moisturizing feeling. ..smooths the skin...takes away the redness and blotchy skin look.


St. Joseph, MO


Great product


The neuropeptide products have no negatives, other than they are expensive. I order them during specials and would recommend them to anyone - even younger than 60+. My older and younger sisters are now exclusively Perricone users for all skincare needs.

Perricone follower

Huntsville, AL


Not as good as Cold Plasma when it comes to firming and twic


Does not firm my skin as well as Cold Plasma and it's twice the price. Go with Cold Plasma!


San Jose, CA



This seems to be drying out my skin. Why?


San jose, ca


I would buy this product again and again.


I am 71 years old and I get compliments from friends about my skin. People think I have had cosmetic procedures, in reality I have been using the Perricone products for about 15 years.


Bethesda, MD




I am leaving this review because I know without a shadow of a doubt that this product was working for me. Three weeks ago, I put down this product to try another. I have noticed that my laugh line wrinkles are the worse I have ever seen....almost to where I wanted to cry. I will never stop using this product ever again. The best thing about it, is that you can use it for targeted areas and it will last a long time. I know it's expensive but I have had the same jar for over one year because I don't goop it all over my face. Perricone products last long....you dont need much... especially this one. I will always use this Neuropeptide cream for my forehead and laugh lines!!!!!! I am thoroughly convinced now!!


Va. Bch


One of my very favorite products


For both eyes and face the Neuropeptide line is a must have for me!!

Kris @ XP



My favorite of all the Perricone products


I've been using 2/day for over 5 years. I've occasionally switched to other Perricone moisturizers because this one is pricey, but there is no comparison. Even though I'm 59, the wrong moisturizer will lead to white heads and blemishes no matter how cautious I am with my regimen. The Neuropeptide Firming Moisturizer hydrates, smoothes, and firms -- yet doesn't (for me), cause sensitivity or blemishes. I've moved to different climates during this time 5 yr period and there was no change in efficacy. This is my #1 priority in skincare. I'd give up anything else in my regimen before this moisturizer!


Boston, MA


Firming Moisturizer

4.4 45


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