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Perricone MD is a three-tier skincare and wellness system that consists of an anti-inflammatory diet, essential dietary supplements and potent topical skincare solutions backed by powerful ingredients, cutting edge research and extensive clinical and consumer studies.

At Perricone MD, we believe in beauty from the inside-out and outside-in. What we feed our bodies and put on our skin directly impact each other. We take a holistic approach to promoting healthy-looking skin and bodies through our Three-Tier Philosophy. It consists of a healthy diet, nutritional supplements and potent topical skincare.

Perricone MD was founded by Dr. Nicholas Perricone, world-renowned author, dermatologist, nutrition specialist and award-winning inventor. His seminal work challenged the skincare industry with its visionary approach to aging and introduction to the advantages of a healthy lifestyle.

A board-certified dermatologist, Certified Nutrition Specialist (C.N.S.) and Master of the American College of Nutrition (M.A.C.N.), he holds over one hundred U.S. and international patents. His pioneering research on how to prevent and reverse the negative effects of chronic and subclinical inflammation, which he asserted was the cause of aging and disease, led to the development of the Perricone MD three-tier philosophy.


Dr. Perricone never accepted the idea that fine lines and wrinkles are an expected part of aging.He found that the inflammation caused by poor nutrition, sun exposure, stress and irritating skincare treatments leads to an increase in free radicals, which can ultimately lead to accelerated signs of aging.Because he discovered this powerful link between inflammation and aging, Dr. Perricone is known as “the father of the inflammation theory.”


Free radicals are unstable oxygen molecules created during basic metabolic functions, and also by sunlight, toxins, smoke, and pollution. They can damage virtually any part of a cell, including the nucleus, where DNA is produced, though they create most damage in the cell plasma membrane. Free radical damage occurs when a free radical seeks an electron and steals it from the cell plasma membrane, damaging the cell plasma membrane, starting a chain reaction of free radical activity. This results in cell dehydration and aging.


There are two kinds of inflammation: visible and subclinical. The aging process is primarily due to subclinical inflammation, which is inflammation at a cellular level. When free radicals attack and damage the cell membrane of a cell, arachidonic acid is produced. This in turn activates certain enzymes resulting in inflammation and accelerated aging.



The best nutrition plan to minimize the visible signs of aging and reduce inflammation consists of lean sources of protein, low-glycemic choices about carbohydrates and fruits and vegetables rather than refined, processed foods. Some foods we love are chicken, wild salmon, old-fashioned oats, berries, fresh vegetables and healthy fats, like those found in avocados, nuts and olive oil.


Since antioxidant levels are difficult to measure at any given moment, the best way to ensure you have steady protection is to control your dietary intake of antioxidants. Our supplements are designed to provide the nutrients that aren’t always obtainable from the foods we eat.


Designed to promote the most visible signs of healthy-looking skin, our formulations are rich in anti-oxidants and nutrients that our bodies naturally create. Because they recognize these ingredients as their own, you will see dramatic results more quickly. The “Three P‘s” of Tier 3 are Performing Ingredients, Patented Sciences and Powerful Results.

Perricone MD products are free from phthalates, sulfates, parabens, oils, talc, mineral oil, silicone, petrolatum and animal cruelty. Many of our products include proprietary sciences that are protected by patents. Some of these innovations include:

Visibly Smooths, brightens and minimizes discoloration.


Visibly lifts sagging skin and plumps skin.


Reduces the appearance of lines, wrinkles and enlarged pores.

Helps protect and replenish fragile skin.

Nourishes and energizes skin for quick, visible results.

For deeper and faster penetration of key ingredients.