OVM Serum with Retinol

OVM Serum with Retinol - Perricone MD
  • OVM Serum with Retinol


OVM Serum with Retinol - Perricone MD
Harnessing effective levels of retinol without irritation, OVM Serum is designed to deliver instant tightening, brightening and smoothing benefits to visibly minimize fine lines and wrinkles. Read More
$84.97 76.47
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Additional Information

Product Details

What It Is

OVM Serum delivers all the benefits of retinol without irritation by harnessing eggshell membrane and effective levels of retinol in a proprietary formula. This powerful overnight serum delivers dramatic and instant tightening and smoothing benefits to minimize the appearance of imperfections such as fine lines and uneven texture. With consistent use over time, skin is revitalized, erasing the appearance of wrinkles while delivering unparalleled softness and brightness to the skin.

What It Does
  • Delivers dramatic, instant tightening and smoothing benefits.
  • Increased appearance of brightness and radiance.
  • Minimize fine lines and wrinkles.
What To Expect

Due to the science and compounds used in our products the feel and scent may vary.






Fresh & Aromatic


Consumer Results

After 4 weeks of use:

80% agreed the serum boosted the youthful cushion of their skin.

78% noticed this serum appeared to boost their skin firmness.

72% noticed this potent treatment was powerful on wrinkles yet gentle on their skin.


DMAE: Instant Firming

Naturally produced by the human brain, DMAE helps visibly lift sagging skin over time. Easily and quickly absorbed, it visibly plumps skin to help support skin's surface and protect against drying environmental aggressors.

Retinol: Exfoliate for Accelerated Regeneration

Ultra-powerful, non-prescription Vitamin-A derivative dramatically reduces the look of fine lines, wrinkles and discoloration over time by accelerating surface skin exfoliation and renewal. Unique slow-release carrier system helps preserve this unstable ingredient and calm skin.

Eggshell Membrane

Harnessed from a non-fertilized egg with scientific precision, the eggshell membrane is rich in nutrients, proteins and peptides ideal for skin rejuvenation.


Water, Glycerin, Sodium Carboxymethyl Beta-Glucan, Egg Shell Membrane Extract, Whey Protein, Dimethyl MEA, Phosphatidylcholine, Magnesium Aspartate, Zinc Gluconate, Sodium Hyaluronate, Copper Gluconate, Retinol, Panthenol, PEG-12, PEG-40 Hydrogenated Castor Oil, PEG/PPG-18/18 Dimethicone, Carbomer, Polysorbate 20, Citric Acid, Phenoxyethanol, Caprylyl Glycol, Sorbic Acid



Dr. Perricone recommends smoothing liberally on cleansed skin in the evening. Wait a few moments and follow with a Perricone MD moisturizer.

Application Process




Pearl-Sized Amount


1x / Day


12 Weeks

  1. Smooth OVM Serum onto cleansed skin in the evening.
  2. Follow with a Perricone MD moisturizer.


Hi, which serum has a higher amount of retinol - OVM or High Potency Evening Repair?

Perricone MD User

These two treatments have comparable amounts of retinol.


What % of retinol is in this product?


This is proprietary information but we will tell you that it contains the highest amount of retinol that you can have without a prescription, as well as skin plumping peptides from the eggshell membrane to increase collagen and elastin in the skin.


I received an OVM serum as a gift. The product was just bought by my family. I used it in conjunction with Cold Plasma+ Face for 7 days. After toning, I applied the Cold Plasma+ Face. Then follow with OVM serum and a moisturizer. I used 4 drops of OVM serum. In the first 4 nights, red spots had been developed, but they disappered afterwards. Then in the latter 3 days, I found the pores to be bigger and skin texture not as smooth as it had been. I wonder if the conditions are the "downtime" to use retinol, as I did not use retinol. How long will my skin return to the previous condition? Also, how long will it takes to get the results designed? Please advice any anti-allergy measures. Regards Andrew

Anri the Curious

We recommend that you discontinue using the OVM Serum for now. Let your skin rest for a week or two and if everything is back to normal we recommend that you reintroduce OVM Serum, but less frequently. Start with once or twice a week and stay there for a while before you decide to increase the frequency of application. If you have sensitive skin we recommend using it only two or three times a week at the most. Results will vary among individuals. It takes 30 days for a healthy cell cycle to turn over and usually it takes a few cycles to begin to start to see results. The anti-aging results are cumulative.


I heard retinol could result in a burning sensation on my skin....my skin is not terribly sensitive but I am a little nervous. However, the skin tightening effects attract me.


OVM Serum contains a new kind of non-inflammatory retinol that is non-irritating and safe.


I use the restoration cream at night and the ovm in the AM. I have just purchased the serum. Should the serum be applied first at night and then the restoration cream.


Yes - that is correct.

Should OVM serum go on before or after cold plasma


Hi there. OVM Serum would go on first.. Dr. Perricone recommends smoothing OVM Serum liberally on cleansed skin in the evening.. You would follow with Cold Plasma & them your moisturizer of choice. Hope this helps. PMD

I'm using high potency evening repair . Should I continue using that or replace with this new OVM now. Do both of them deliver the same results?


Hi there. Thinking that you are speaking to the OVM Serum.. You would use the OVM Serum first followed by the High Potency Evening Repair. Both are best used in the PM. Hope this helps. PMD

Hello, Can you please advise which Perricone products I should use for melasma ? I wanted to buy re-firm to tighten my jaw line, but maybe there is another alternative moist, etc for me due to the fact my cheeks have pigmentation due to melasma. Ever grateful !


Hi there. While melisma is a medical condition & we do not make medical claims - we would recommend that you try out Vitamin C Ester 15. Vitamin C Ester 15 helps minimize the appearance of discoloration unveiling an elegant radiance. That would be out top choice. Hope this helps. PMD

I currently use OVM in the morning. What does this new OVM serum have that the other does not? Should I be using them both, one in the morning and the other at night?


Great question! OVM delivers extraordinary results, increasing the appearance of skin's volume, cushion and firmness for a 3-dimensional anti-aging effect. Adding OVM Serum in the evening will enhance your results. The additional Retinol and DMAE work together to instantly impart the appearance of renewed inner radiance and glow.

Perricone MD skincare specialist

What is the difference between ovm cream and now the new ovm serum ? Do you use both ?


Great question. You can absolutely use both for optimal results. Both products are harnessing the power of Eggshell Membrane which is rich in nutrients, proteins and peptides for skin rejuvenation. OVM is now formulated with Vitamin C Ester and Vitamin E to nourish and brighten the skin. And the OVM Serum has DMAE for instant tightening benefits. You can use one during the day and one at night.

Perricone MD Skincare Specialist




A must Serum to have


Great and gentle Retinol to use nightly

the Young at Heart

Mission Viejo, CA


I will purchase this product again!


I usually only write reviews when I'm unhappy with a product so this is a first. I have tried nearly everything on the market and discovered Perricone less than a year ago. I always thought of it as my mother's brand so I avoided it for years. Much to my surprise Perricone products actually do wonders for my 51 year old, dry, sensitive skin. I purchased the Ovum serum, honestly, because I needed an extra product in order to be eligible for free shipping. I didn't have any expectations and so I was amazed at the results! The fine lines on my forehead are much reduced, the few large pores around my nose are barely visible and the couple sunspots I had above my eyebrows are faded. Even my overall skin color and texture is visibly improved. People have actually complimented in my skin and my favorite part is that I saw results immediately. I don't know if this product will have such excellent results for everyone but it's working beautifully for me!




Younger looking skin


Love this product. I'm so glad I bought 2 for myself when it was on sale. My skin feels tighter and looks smoother.


Honey Brook


Awesome serum


This works! It's the ONE product that has made a huge difference. My skin is softer and more even, my breakouts have subsided and my skin looks refreshed. I didn't want to believe all the great reviews at first since it is an expensive product, but I ended up purchasing it during a sale. Please never change or discontinue this product!


San Francisco


My third bottle of OVM !


Seems to keep discoloration at bay.


Marietta GA


Hmm...I'm very surprised at these reviews


I am a big fan of the PerriconeMD line, however, I have found this product to be extremely ineffective. I have used it religiously and as directed for 5 weeks. I will be returning this product.






Works great on acne too

On the go

New York


Does everything it promises!!


Works very well but not exactly crazy about the smell but disappears over time.


Buffalo NY


I would buy this product again and again


I use OVM Serum every evening before I use my Evening Repair moisturizer and I LOVE IT.


Hendersonville, NC


In Love


Have been using for 2 weeks and my skin is brighter,tighter and just younger looking.




OVM Serum with Retinol

4.6 16


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