#5705

Acyl-Glutathione Deep Crease Serum

Acyl-Glutathione Deep Crease Serum - Perricone MD
  • Acyl-Glutathione Deep Crease Serum

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Acyl-Glutathione Deep Crease Serum - Perricone MD
Formulated with Dr. Perricone’s patented Acyl-Glutathione, this powerful anti-aging treatment is designed to address visible expression lines and creases that appear from repetitive facial movements to help achieve a more youthful looking appearance. Read More
$ 185.00 166.50
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Additional Information

Product Details

What It Is

Formulated with Dr. Perricone’s patented Acyl-Glutathione, this powerful anti-aging treatment is designed to address visible expression lines and creases that appear from repetitive facial movements. Over time, these engraved imperfections appear instantly smoothed, making creases appear shallower and erasing the look of furrow creases along the forehead, squinting creases and feathery lines along the lips to help achieve a more youthful looking appearance.

What It Does
  • Softens the look of facial lines from daily repetitive movements.
  • Visibly improves etched creases making them appear more shallow.
  • Minimizes the appearance of skin imperfections and imparts a beautiful radiance.
What To Expect

Due to the science and compounds used in our products the feel and scent may vary.

Texture

Serum

Consistency

Lightweight

Scent

Natural, Aromatic

Key Sciences

Acyl-Glutathione

Comprised of three amino acids, glutathione is the body's main antioxidant and helps to reduce the look of deep wrinkles and creases by protecting and replenishing fragile skin. Natural levels of this essential building block deplete over time, but topical application can help skin appear smoother and more youthful.

Neuropeptides

Powerful, protein-like building blocks offer the ultimate visible antidote to wrinkles, sagging, dullness, and discoloration. Neuropeptides encourage surface skin cells to work together via a unique chemical structure.

Acyl-Glutathione Deep Crease Serum Science

Ingredients

Acyl-Glutathione

Comprised of three amino acids, glutathione is the body's main antioxidant and helps to reduce the look of deep wrinkles and creases by protecting and replenishing fragile skin. Natural levels of this essential building block deplete over time, but topical application can help skin appear smoother and more youthful.

Neuropeptides

Powerful, protein-like building blocks offer the ultimate visible antidote to wrinkles, sagging, dullness, and discoloration. Neuropeptides encourage surface skin cells to work together via a unique chemical structure.

Ingredients

Water/Aqua/Eau, Glycerin, Tetrahexyldecyl Ascorbate, S-Palmitoylglutathione, Isopropyl Palmitate, Squalane, Butylene Glycol, Cyclopentasiloxane, Cetearyl Alcohol, Glycolic Acid, Glyceryl Stearate, PEG-100 Stearate, Dimethicone, Dimethyl MEA, Cyclohexasiloxane, Ceteareth-20, Fragrance/Parfum, Phenoxyethanol, Zinc Gluconate, Magnesium Aspartate, Caprylyl Glycol, Phosphatidylcholine, Disodium EDTA, Citric Acid, Docosahexaenoic Acid, Sorbic Acid, Linalool, Copper Gluconate, Tetrapeptide-21, Citronellol, Sodium Hyaluronate, Geraniol, Limonene, Acetyl Hexapeptide-8, Pentapeptide-18, Citral.

Application

Application

Dr. Perricone recommends smoothing onto a cleansed face in the morning, paying special attention to visible expression lines and creases. Follow with a Perricone MD moisturizer.

Application Process

Area

Face

Amount

1 - 2 Pumps

Frequency

1x / Day

Duration

8 Weeks

  1. Dispense 1 to 2 pumps onto fingertips.
  2. Smooth onto face, paying special attention to visible expression lines and creases.
  3. Use in the morning.
  4. Follow with a Perricone MD moisturizer.

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Q&A

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65 Questions | 66 Answers
Displaying questions 1-10Previous | Next »
  • Q:

    Hello. Does this product actually treat laugh lines or is it a temporary fix l? Will results stop once you stop using it? And how would i incorporate this if I use retin a at night? Thank you!
    Asked on 1/29/2016 by Melissa

    1 answer

    • Perricone MD Skincare Specialist

      A:

      Good question. The Acyl-Deep Crease Serum is an amazing daily spot treatment to be used for laugh lines, crows feet, the "elevens" and forehead area. Over time you will see the appearance of fine lines diminish. You can use day and night under your Retin A or just use in the morning.

      Answered on 3/10/2016 by Perricone MD Skincare Specialist
  • Q:

    What is the percentage of glycolic acid in this product?
    Asked on 10/23/2015 by Ghotsibi from Fresno, Ca

    1 answer

    • Staff Reviewer

      A:

      Good question!

      There is a little over 2% of glycolic acid in the Acyl-Glutathione Deep Crease Serum.

      Have a nice day!

      Answered on 10/26/2015 by Perricone MD Customer Care Specialist from Perricone MD Customer Care
  • Q:

    Hello,
    Would I apply Acyl-Glutathione Deep crease Serum before or after Cold Plasma? And then apply Acyl-Glutathione Creme on top and them the final moisturiser( Neuropepeptide Firming moisturiser)
    Thank you
    Asked on 10/20/2015 by Budde from Ny

    1 answer

    • Staff Reviewer

      A:

      Great question!

      There are five steps to following the Perricone regime and they are:

      1a. Cleanser
      1b. Treatment Mask
      2. Toner or Serum
      3. Exfoliant
      4. Treatment
      5. Moisturizer

      The Acy-Glutathione Deep Crease Serum (Step 2) should be applied first then apply the Cold Plasma (Step 4), follow with the Acyl-Glutathione cream (Step 4) and the moisturizer (NP Firming Moisturizer) (Step 5) should always be applied last.

      Have a nice day!

      Answered on 10/22/2015 by Perricone MD Customer Care Specialist from Perricone MD Customer Care
  • Q:

    I am going to buy acyl-glutathione deep crease serum but wonder if I can use it with the concentrated restorative cream at night or should I rotate using them every other night? I break out with the face firming moisturizer so I use no moisturizer. Any suggestions for that?
    Asked on 8/27/2015 by Kat from TN

    1 answer

    • Staff Reviewer

      A:

      Thank you for your interest in Dr. Perricone's products.

      All of Dr. Perricone's products can be used together and it is perfectly fine to use both the Acyl-Glutathione Deep Crease Serum and the Concentrated Restorative Cream daily or every other day; which ever you prefer.

      Since you are unable to use the Face Finishing Moisturizer I recommend the Hypoallergenic Nourishing Moisturizer from Dr. Perricone's sensitive skin care line.

      Have a nice day!

      Answered on 9/3/2015 by Perricone MD Skincare Specialist from Perricone MD Customer Care
  • Q:

    Hello , I am 22 years old and i lost over 50 lbs recently and im starting to see Jowls or Marionettes around my smile....is this product good for that? Or should I try another Perricone MD product?
    Asked on 6/14/2015 by Angie from new york

    1 answer

    • Staff Reviewer

      A:

      Great question!

      Yes, the Acyl-Glutathione Deep Crease Serum will definitely address the smile lines and expression lines.

      Acyl-Glutathione Deep Crease Serum is a powerful anti-aging treatment designed to address expression lines and creases that appear from repetitive facial movements. Upon first application, these engraved imperfections appear instantly smoothed, making creases appear shallower and erasing the look of furrow creases along the forehead, squinting creases and feathery lines along the lips. Combined with its illuminating effect, this anti-aging serum is the ideal non-invasive alternative to help achieve a more youthful looking appearance.

      Answered on 8/1/2015 by Perricone MD Skincare Specialist from Perricone MD Customer Care
  • Q:

    I have A-G deep crease serum, vit c ester 15,nueropeptide firming moisturizer, chia oil, chloroplasma and blue plasma. Kindly guide me how to use them. Also what r ur most powerful anti aging products. I'm 53 years and have droopy mouth corners, droopy eyelids. Thanks
    Asked on 5/30/2015 by r

    1 answer

    • Staff Reviewer

      A:

      Thank you for contacting Perricone MD.

      There are five steps to following the Perricone regime and they are:

      1. Cleanser
      2. Toner or Serum
      3. Exfoliant
      4. Treatment
      5. Moisturizer

      Please see Application Protocol below:

      AM PRODUCTS PM PRODUCTS
      Cleanser Cleanser
      Chloro Plasma (2-3 times per week) Blue Plasma
      Acyl-Glutathione Deep Crease Serum Acyl-Glutathione Deep Crease
      NP Firming Moisturizer/chia serum NP Firming Moisturizer/chia serum

      The Chia Serum can be mixed with Neuropeptide Firming Moisturizer to provide additional moisture, or it can be used alone without moisturizer.

      I hope this is helpful.

      Answered on 6/12/2015 by Perricone MD Skincare Specialist from Perricone MD Customer Care
  • Q:

    Does this go before Cold Plasma or after? Does this go before Vitamin C Serum? What order do Cold Plasma, Hyalo, Vitamin C Serum, and Acyl-Glutathione go in? Please do not advise me to the protocol page because it's not been helpful thus far.
    Asked on 4/5/2015 by fit3two

    1 answer

    • Staff Reviewer

      A:

      Thank you for contacting Perricone MD.

      There are five steps to following the Perricone regime and they are:

      1. Cleanser
      2. Toner or Serum
      3. Exfoliant – (PM ONLY)
      4. Treatment
      5. Moisturizer

      The Acyl-Glutathione Deep Crease Serum (Step 2) for both AM & PM application.

      The Cold Plasma (Step 4) treatment is always the very first Perricone treatment applied both AM & PM.

      Vitamin C Ester Serum (Step 2) this is an AM serum and since you are also using the Acyl-Glutathione Deep Crease serum I recommend alternating, Use Vitamin C Serum in the AM and the Acyl-serum in the PM.

      Acyl-Glutathione (Step 4) treatment should be applied AM & PM after the Cold Plasma.

      Hyalo Plasma (Step 4) treatment should be applied after the Acyl-Glutathione both AM & PM.

      A moisturizer should always follow last.

      We also have an Application Protocol Sheet listed on our website: www.perriconemd.com; simply click at the top of the page on Customer Service, and to the left you will see a drop down menu, click on "Application Protocol".

      I hope this is helpful.

      Answered on 4/29/2015 by Perricone MD Skincare Specialist from Perricone MD Customer Care
  • Q:

    I bought the Acyl-glutathione Deep Crease serum and it really works,but I get a TERRIBLE headache on my forehead after I use it. I mean blistering headache,I was wondering if this has happened before andwhat in it would cause this. I can't use the product anymore,I can't function if I do.Too bad, I love the results.
    Asked on 2/9/2015 by Julie from Canada

    1 answer

    • Staff Reviewer

      A:

      Thank you for contacting Perricone MD.

      We regret to hear of your experience although we have never received this type of complaint or heard of this occurring after using the Acyl-Glutathione Deep Crease Serum.

      Most people do not have any problem using Dr. Perricone’s products, but there unfortunately is no list of ingredients that can be guaranteed to not disagree. Persons who have sensitive’s should pay careful attention to what they use on their skin. It is virtually impossible to know if, when, or how anyone will react to any cosmetic.

      I recommend discontinuing usage of this product and returning for a refund.

      We have a variety of products that will address your concerns that contain different ingredients and I recommend calling our Customer Service Department (888-823-7837) and requesting a Skin Care Consultation,.

      I hope this is helpful.

      Answered on 2/10/2015 by Perricone MD Skincare Specialist from Perricone MD Customer Care
  • Q:

    I am trying to decide whether I want the Acyl-Glutathione Deep Crease Serum v. the Acyl-Gluthathione. I use the A-G Eye Serum and I love it, I want to use the A-G on my face, but I don't know if I should get the serum or the other A-G product which I assume is also a treatment product and not a moisturizer. Please help as I am not sure what the difference is between those two products. Should they all be used together? Thank you!
    Asked on 1/29/2015 by Katina from Pennsylvania

    1 answer

    • Staff Reviewer

      A:

      Thank you for contacting Perricone MD.

      There are five steps to following the Perricone regime and they are:

      1. Cleanser
      2. Toner or Serum
      3. Exfoliant
      4. Treatment
      5. Moisturizer

      The Acyl-Glutathione Deep Crease Serum (Step 2) is a serum and the Acyl-Glutathione (Step 4) is the treatment.

      If you are only able to purchase one I recommend the Acyl-Glutathione cream which is a powerful treatment that diminishes expression lines, wrinkles and creases.

      This treatment is applied both AM & PM and a moisturizer should always follow last.

      I hope this is helpful.

      Answered on 2/2/2015 by Perricone MD Skincare Specialist from Perricone MD Customer Care
  • Q:

    Hi,
    I'm using Amine Facelift in AM and High Potency Evening Repair at bedtime.

    In the AM prior to putting on makeup, can Acyl-Glutathione Deep Crease Serum be used BEFORE OR AFTER the Amine Facelift to help diminish lines, OR should it NOT be combined with Amine Facelift at all?
    Asked on 1/19/2015 by nu from Northern California

    1 answer

    • Staff Reviewer

      A:

      Great question! The Acyl-Glutathione Deep Crease Serum should be used before your High Potency Amine Face Lift during the day, and before the High Potency Evening Repair at night.

      Answered on 1/26/2015 by Anonymous
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Reviews

Reviews

REVIEW SNAPSHOT®

by PowerReviews
Acyl-Glutathione Deep Crease Serum
 
3.6

(based on 45 reviews)

Ratings Distribution

  • 5 Stars

     

    (18)

  • 4 Stars

     

    (12)

  • 3 Stars

     

    (2)

  • 2 Stars

     

    (5)

  • 1 Stars

     

    (8)

69%

of respondents would recommend this to a friend.

Pros

  • Lightweight (20)
  • Non-greasy (16)
  • Softens skin (9)
  • Smells great (8)
  • Moisturizes (7)

Cons

No Cons

Best Uses

  • Fine lines/wrinkles (16)
  • Daily use (15)
    • Reviewer Profile:
    • Beauty conscious (17), Survivalist / minimalist (4)
    • Skin Type:
    • Combination (12), Normal (6), Dry (5)
    • Was this a gift?:
    • No (19)

Most Liked Positive Review

 

Love this!!!

First, I absolutely love having a product to specifically treat expression lines and creases. Secondly and most importantly, it works!! The day I began to use the product, I was hating marionette...Read complete review

First, I absolutely love having a product to specifically treat expression lines and creases. Secondly and most importantly, it works!! The day I began to use the product, I was hating marionette lines on my face but I had hope. Three days later, I have jumped back to a point in time when I didn't mind having them. That's huge for me -- from lined to just a bit lined. I massage the product into crease areas as directed. Thank you so much! I have another Perricone MD staple.

VS

Most Liked Negative Review

 

No, I would not recommend this product .

I use this product exactly as Dr. Perricone suggests. I massage it in to deep creases and wrinkles. I see absolutely no results at all, I, in fact, am returning the product...Read complete review

I use this product exactly as Dr. Perricone suggests. I massage it in to deep creases and wrinkles. I see absolutely no results at all, I, in fact, am returning the product for something else. It smells good. That is all I can say for the product. It is also very pricey, to do nothing for me. I do love most of the rest of Perricone products. I will call and speak to a skin consultant today.I was just thinking I needed to call about this product, so I am glad for the review. Wish I could have given better, but it does not work for me.
Thank you

Reviewed by 45 customers

Displaying reviews 1-10

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1.0

No Evidence of Any Improvement

By CLW-G

from NYC

About Me Beauty Conscious

Verified Reviewer

Pros

  • Lightweight
  • Non-Greasy

Cons

    Best Uses

      Comments about Acyl-Glutathione Deep Crease Serum:

      After over two weeks of application morning and evening, I see no evidence that wrinkles are fading, or any other effect.

      • Skin Type:
      • Normal
      • Age:
      • 60+
       
      4.0

      Love it

      By JD

      from Jackson, MS

      About Me Beauty Conscious

      Pros

      • Firms eyelid area
      • Lightweight
      • Non-Greasy

      Cons

        Best Uses

        • Daily Use
        • Fine Lines/Wrinkles

        Comments about Acyl-Glutathione Deep Crease Serum:

        Love this product! It does take time for you to see the true effects, but it's worth every penny!

        • Skin Type:
        • Combination
         
        1.0

        I would not buy again

        By dont have one

        from NY

        About Me Minimalist

        Comments about Acyl-Glutathione Deep Crease Serum:

        I was using this under my daily cream, it does not hide the creases at all, not happy about that. Also the push top always spurts it all over. I like the daily cream.

        • Skin Type:
        • Normal
        • Age:
        • 60+
         
        1.0

        No difference

        By Phillygirl

        from Concord NC

        About Me Beauty Conscious

        Verified Reviewer

        Pros

        • Lightweight
        • Non-Greasy
        • Smells Great

        Cons

        • Not Effective

        Best Uses

        • Daily Use
        • Fine Lines/Wrinkles
        • Redness/ Blotchiness

        Comments about Acyl-Glutathione Deep Crease Serum:

        It may be too soo but I see no change.

        • Skin Type:
        • Dry
        • Age:
        • 60+
         
        5.0

        Delicate Effectiveness

        By Alex

        from Wakefield RI

        About Me Beauty Conscious

        Verified Reviewer

        Pros

        • Lightweight
        • Moisturizes
        • Non-Greasy
        • Smells Great
        • Softens Skin

        Cons

          Best Uses

          • Daily Use

          Comments about Acyl-Glutathione Deep Crease Serum:

          Product doesn't behave like a wrinkle " filler" but does soften fine lines without clogging pores or
          Creating a dry area where applied .

          • Skin Type:
          • Normal
          • Age:
          • 60+
           
          4.0

          i really haven't tried this long enough.

          By Sara

          from Pittsburgh

          About Me Beauty Expert

          Pros

          • Lightweight
          • Moisturizes
          • Non-Greasy
          • Softens Skin

          Cons

            Best Uses

            • Daily Use
            • Sensitive Skin

            Comments about Acyl-Glutathione Deep Crease Serum:

            I have been using this only about 10 days. I can't really tell if it will make my deep wrinkles improve, but I think I am seeing an improvement.

            • Skin Type:
            • Dry
            • Age:
            • 60+
             
            5.0

            One of the BEST

            By Alex

            from Wakefield RI

            About Me Beauty Conscious

            Verified Reviewer

            Pros

            • Lightweight
            • Moisturizes
            • Smells Great
            • Softens Skin

            Cons

              Best Uses

              • Daily Use
              • Fine Lines/Wrinkles

              Comments about Acyl-Glutathione Deep Crease Serum:

              Of all the serums including others by Perricone
              This is a wonderful addition that promises and delivers great results

              • Skin Type:
              • Combination
              • Age:
              • 60+
               
              4.0

              I like the product but...

              By Sweak

              from Illinois

              About Me Beauty Conscious

              Verified Reviewer

              Pros

              • Lightweight
              • Softens Skin

              Cons

                Best Uses

                • Fine Lines/Wrinkles

                Comments about Acyl-Glutathione Deep Crease Serum:

                The pump needs some work. It sticks, then dispenses too much serum. I've had the same problem with the eyelid serum as well. I do feel like this serum helps my laugh lines.

                • Skin Type:
                • Normal
                • Age:
                • 60+
                 
                3.0

                I will continue to use

                By Christine

                from Hoboken NJ

                About Me Beauty Conscious

                Verified Reviewer

                Pros

                • Lightweight
                • Non-Greasy
                • Softens Skin

                Cons

                  Best Uses

                  • Fine Lines/Wrinkles

                  Comments about Acyl-Glutathione Deep Crease Serum:

                  The product is light but penetrates slowly. I would like to have seen results quicker but I just started using about a month ago so will give it more time

                  • Skin Type:
                  • Combination
                  • Age:
                  • 45-59
                   
                  5.0

                  I don't go a day without it!

                  By Pilates Patty

                  from Long Beach, CA

                  About Me Beauty Conscious

                  Verified Reviewer

                  Pros

                  • Lightweight
                  • Moisturizes
                  • Non-Greasy
                  • Softens Skin
                  • Soothes Skin

                  Cons

                    Best Uses

                    • Daily Use
                    • Fine Lines/Wrinkles

                    Comments about Acyl-Glutathione Deep Crease Serum:

                    I have used this product faithfully for a few years along with the eye serum and I am really pleased with the results. Recently, a friend that I hadn't seen in a while thought I had my eyes done. For sure the other amazing Perricone products that I use contribute!

                    • Skin Type:
                    • Combination
                    • Age:
                    • 45-59

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