#5703

Acyl-Glutathione

(144) Read Reviews
Acyl-Glutathione - Perricone MD
  • Acyl-Glutathione

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Acyl-Glutathione - Perricone MD
(144) Read Reviews
Formulated with Dr. Perricone’s patented Acyl-Glutathione, this treatment is specifically designed to minimize the look of creases while improving the appearance of thinner, more fragile-looking skin texture for overall visibly younger skin. Read More
$ 185.00 166.50
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Additional Information

Product Details

What It Is

Formulated with Dr. Perricone’s patented Acyl-Glutathione, this treatment is specifically designed to minimize the look of lines and creases while improving the appearance of thinner, more fragile-looking skin texture for overall visibly younger skin.

What It Does
  • Diminishes the look of creases along targeted areas of the face.
  • Enhances the appearance of skin's elasticity and resilience.
  • Visibly improves fragile skin texture while imparting the radiance of youthful skin.
What To Expect

Due to the science and compounds used in our products the feel and scent may vary.

Texture

Lotion

Consistency

Lightweight

Scent

Natural, Aromatic

Key Sciences

DMAE

Naturally produced by the human brain, DMAE helps visibly lift sagging skin over time. Easily and quickly absorbed, it visibly plumps skin to help support skin's surface and protect against drying environmental aggressors.

Acyl-Glutathione

Comprised of three amino acids, glutathione is the body's main antioxidant and helps to reduce the look of deep wrinkles and creases by protecting and replenishing fragile skin. Natural levels of this essential building block deplete over time, but topical application can help skin appear smoother and more youthful.

Acyl-Glutathione Science

Ingredients

DMAE

Naturally produced by the human brain, DMAE helps visibly lift sagging skin over time. Easily and quickly absorbed, it visibly plumps skin to help support skin's surface and protect against drying environmental aggressors.

Acyl-Glutathione

Comprised of three amino acids, glutathione is the body's main antioxidant and helps to reduce the look of deep wrinkles and creases by protecting and replenishing fragile skin. Natural levels of this essential building block deplete over time, but topical application can help skin appear smoother and more youthful.

Ingredients

Aqua (Water), Isopropyl Palmitate, Tetrahexyldecyl Ascorbate, Cetearyl Alcohol, Phosphatidylcholine, S-Palmitoylglutathione, L-Tyrosine, Dimethyl MEA (DMAE), Glyceryl Stearate, PEG-100 Stearate, Ceteareth-20, Glycolic Acid, Oligopeptide-17, Oligopeptide-49, Squalane, Butyrospermum Parkii (Shea) Butter, Limnanthes Alba (Meadowfoam) Seed Oil, Docosahexaenoic Acid, Dimethicone, Sesamum Indicum (Sesame) Seed Oil, Glycerin, Magnesium Aspartate, Zinc Gluconate, Phenoxyethanol, Caprylyl Glycol, Parfum (Fragrance), Propylene Glycol, Disodium EDTA, Hydrolyzed Glycosaminoglycans, Elaeis Guineensis (Palm) Oil, Citric Acid, Tocotrienols, Copper Gluconate, Sorbic Acid, Tocopherol, Ascorbyl Palmitate, Thioctic Acid (Alpha-Lipoic Acid), Linalool

Application

Application

Dr. Perricone recommends massaging onto a cleansed face and neck in the evening. Follow with a Perricone MD moisturizer.

Application Process

Area

Face and Neck

Amount

Pearl-Sized Amount

Frequency

1x / Day

Duration

8 Weeks

  1. Dispense pearl-sized amount onto fingertips.
  2. Smooth onto face, paying special attention to visible expression lines and creases.
  3. Use in the evening.
  4. Follow with a Perricone MD moisturizer.

Q&A

Do you have questions about this product?

Get answers from real customers and in-house experts with AnswerBox.

21 Questions | 21 Answers
Displaying questions 1-10Previous | Next »
  • Q:

    This says it is for the face and neck, but you describe the application for around the eyes; the application is wrong on your website.
    Asked on 2/27/2016 by KS

    1 answer

    • Perricone MD Skincare Specialist

      A:

      Great feedback. Thank you for bring to our attention. You are right the applications steps 1-5 are incorrect. I will mention this to corporate. Thank you

      Answered on 3/8/2016 by Perricone MD Skincare Specialist
  • Q:

    My a.m. face routine - intensive pore minimizer, blue plasma, cold plasma,high potency face lift and FF moisturizer. My p.m. face routine - serum prep, cold plasma, high potency evening repair and FF moisturizer. Would the AG cream be good to add to this routine, and if so at what step in the routines? Should it replace any of the products I currently use? Should this be applied to the whole face or just problem areas?
    Thank you!
    Asked on 4/8/2014 by TotalPerriconeConvert from Dayton, OH

    1 answer

    • Staff Reviewer

      A:

      Acyl-Glutathione is a phenomenal treatment that addresses the following concerns:• Severe skin dryness
      • Deeper set lines and wrinkles especially on targeted areas of the face
      • Thinner, more fragile looking skin
      • Extreme loss of elasticity leading to visible sagging appearance
      • Lack of energy and vitality on the skin leading to dullness

      If these are your concerns I recommend adding to your current regime. This treatment should be applied after the Cold Plasma both in the AM &PM, follow with other Perricone products and moisturizer is always last.

      Have a nice day!

      Answered on 4/8/2014 by Perricone MD Skincare Specialist from Perricone MD Customer Care
  • Q:

    How do you use it? How do you put it on?
    Asked on 4/6/2014 by The youn 58 year old. from Newark, Ca.

    1 answer

    • Staff Reviewer

      A:

      Dr. Perricone recommends first warming up a small amount of product between your hands to facilitate spread over the entire face. Slide the pads of the fingers from the center of the eyebrows towards the outside of the forehead.

      Then with the palms of the hand proceed over temples, cheekbones and sides of nose in a gentle patting motion. End by sweeping upwards from the neck to the chin and jawline. Apply morning and evening after make-up removal on well cleansed skin.

      Answered on 4/8/2014 by Perricone MD Skincare Specialist from Perricone MD Customer Care
  • Q:

    Hi. I'm 41 and starting to deal with 11 wrinkles, creases along the forehead and laughter lines. I recently bought the complete acyl-glutathione line (both serums and the AG). I also use Formula 15, Vitamin C Ester. What would be the best way to combine them for optimal and fast results? Should I alternate them? Thank you.
    Asked on 3/25/2014 by Margit from São Paulo, Brazil

    1 answer

    • Staff Reviewer

      A:

      It is not necessary to use both the Formula 15 and Acyl-Glutathione Cream in the AM; so I recommend alternating. Since Formula 15 is an AM treatment use the serum, then the Formula 15 and a moisturizer is always applied last.

      In the PM apply Acyl-Glutathione Deep Crease Serum, Vitamin C Ester 15, Acyl-Glutathione Cream and moisturizer last.

      I hope this is helpful.

      Answered on 4/1/2014 by Perricone MD Skincare Specialist from Perricone MD Customer Care
  • Q:

    what is the expiry date for this
    Asked on 3/14/2014 by hi

    1 answer

    • Staff Reviewer

      A:

      All of Dr. Perricone's products have a 2 year shelf life.

      Answered on 3/19/2014 by Perricone MD Customer Care
  • Q:

    do you use this at night on top of c-ester and or 15 or under. I uses them every other night and ovm in the morning
    Asked on 2/10/2014 by vicki from indialantic fl

    1 answer

    • Staff Reviewer

      A:

      The Vitamin C Ester 15 is a night time serum and should be applied after cleansing, then apply the Acyl-Glutathione and a moisturizer is always recommended last. If you are using an AM treatment that contains the vitamin c ester, such as the High Potency Amine Complex Face Lift, the Acyl-Glutathione is applied first then the HP Amine and a moisturizer last.

      Answered on 2/11/2014 by Perricone MD Skincare Specialist from Perricone MD Customer Care
  • Q:

    Received for a gift the cold plasma and the acrylic glutathione and I am not sure how to use or when. Can you assist me?
    Asked on 1/26/2014 by Jeanie from Oxford ga

    1 answer

    • Staff Reviewer

      A:

      Thank you for contacting Perricone MD.

      The Cold Plasma is always the very first treatment applied after cleansing and using either a serum or toner; then follow with the Acyl-Glutathione and Dr. Perricone recommends applying a moisturizer last over treatments; this should be done both AM and PM.

      I hope this is helpful.

      Answered on 1/29/2014 by Perricone MD Skincare Specialist from Perricone MD Customer Care
  • Q:

    Do I have to wait to apply acyl-glutathione after co;d plasma or do I aply immediately after cold plasma? Does photo plasma go right on after or again do I have to wait a bit and let the other absorb?
    Asked on 1/14/2014 by lynn from homer ,IL

    1 answer

    • Staff Reviewer

      A:

      Dr. Perricone's products absorb very quickly into the skin and it is not necessary to wait in between applications; the Acyl-Glutathione can be applied immediately after Cold Plasma. Photo Plasma is a moisturizer and it is always applied last. I hope this is helpful.

      Answered on 1/14/2014 by Perricone MD Skincare Specialist from Perricone MD Customer Care
  • Q:

    It can be used alone without a humidifier cream?
    Asked on 1/3/2014 by Tanya

    1 answer

    • Staff Reviewer

      A:

      The Acyl-Glutathione is considered a treatment so you would use a moisturizer after applying this product.

      Answered on 1/3/2014 by Perricone MD Customer Care
  • Q:

    does one need to use a moisture over this product?
    If so what one would be recommended?
    Asked on 12/27/2013 by justcarol from So CA

    1 answer

    • Staff Reviewer

      A:

      The Acyl-Glutathione is considered a treatment to be used twice per day. Perricone recommends using a moisturizer over the top. We have different moisturizers depending on your concerns and the age of your skin. You may view all of our moisturizers on www.perriconemd.com.

      Answered on 12/29/2013 by Perricone MD Customer Care
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Reviews

Reviews

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by PowerReviews
Acyl-Glutathione
 
4.5

(based on 144 reviews)

Ratings Distribution

  • 5 Stars

     

    (112)

  • 4 Stars

     

    (14)

  • 3 Stars

     

    (5)

  • 2 Stars

     

    (1)

  • 1 Stars

     

    (12)

90%

of respondents would recommend this to a friend.

Pros

  • Non-greasy (12)
  • Softens skin (12)
  • Lightweight (9)
  • Smells great (9)
  • Moisturizes (7)

Cons

  • Pricey / poor value (5)
  • Price (3)
  • Pricey (3)

Best Uses

  • Daily use (8)
  • Fine lines/wrinkles (8)
  • Morning and evening (6)
  • Uneven skin tone (6)
  • Sensitive skin (4)
    • Reviewer Profile:
    • Beauty conscious (5), Brand buyer (4)
    • Skin Type:
    • Dry (5)
    • Was this a gift?:
    • No (4)

Most Liked Positive Review

 

Dramatic Great Results

As a faithful user of most Dr Perricone's products, I was following the launch of Acyl-Glutathione with great interest and I was waiting impatiently for it to cross the Atlantic and to reach us...Read complete review

As a faithful user of most Dr Perricone's products, I was following the launch of Acyl-Glutathione with great interest and I was waiting impatiently for it to cross the Atlantic and to reach us in the UK.
As one of the very first users, I have refrained myself to write an immediate review documenting the dramatic and instant difference it has made to my skin. I wanted to see the developing benefits; so, I could give a more accurate and detailed review.
For someone who is slightly over 50, I have a very good skin that I have looked after very well by following anti-inflammatory diets, excercise,and I have been using faithfully Dr Perricone's products.

Acyl-Glutathione gave me an immediate radiance, a healthy glow, erased a few wrinkles on my forehead and to my utmost surprise had a lifting properties to it that was superior to the Neuropeptide's conformer, in my case.

I use it morning and evening after cleansing with Nutritive cleanser.
At first, I wanted to examine its power so I used it alone and only added the Face Finishing Moisturiser. I can assure you that these products together represent a marriage made in heaven.

If you havent been using any Perricone's products these three products are a must.

If you have been using other products, and all depends on what you have, this is a very suitable order for their applications:
1. Cleansing
2. Serum Prep (in my case) or your toner
3. Cold plasma eye, Cold Plasma, and Cold Plasma Sub D
4. Acyl-Glutathione
5. Advanced Face Firming Activator or High Potency Face Amine Lift (I alternate during the day) and I use the Concentrated Restorative Cream in the evening application
6. Face Finishing Moisturiser or the Neuropetide Moisturiser.

Well done Dr Perricone and Thank you, again.

VS

Most Liked Negative Review

 

Don't use if you have sensitive skin

I'm 50 and have fair skin with very few wrinkles;however, I have noticed that since I have lost weight I have a lack of firmness around my mouth. I have used the...Read complete review

I'm 50 and have fair skin with very few wrinkles;however, I have noticed that since I have lost weight I have a lack of firmness around my mouth. I have used the Dr. Perricone's eye C-Ester and firming lotion for the past year and I have liked those. So I thought I would give this product a chance. I've been using it for a week and have developed red, itchy skin, and a couple of bumps. My skin also has a burning sensation. So Dr. Perricone should note that this product should not be used on sensitive skin or on people who have Rosacea.

Reviewed by 144 customers

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5.0

I would absolutely buy this product again

By Jenny

from Australia

About Me Beauty Conscious

Verified Reviewer

Pros

  • Lightweight
  • Moisturizes
  • Non-Greasy
  • Smells Great
  • Softens Skin

Cons

    Best Uses

    • Daily Use
    • Fine Lines/Wrinkles
    • Uneven Skin Tone

    Comments about Acyl-Glutathione:

    I put this product on after OVM serum in the evening and before applying Face finishing moisturiser. It is a beautiful product that glides on the skin addressing fine line and texture. I have been using for a little over two weeks and I have noticed a difference already.

    • Skin Type:
    • Combination
    • Age:
    • 30-44
     
    4.0

    I would buy this product again.

    By Jan

    from Santa Ana, CA

    About Me Beauty Conscious

    Pros

    • Lightweight
    • Non-Greasy

    Cons

      Best Uses

      • Daily Use
      • Fine Lines/Wrinkles

      Comments about Acyl-Glutathione:

      Better results than deep crease serum.

      • Skin Type:
      • Normal
      • Age:
      • 60+
       
      5.0

      Love this product!!

      By LL

      from Omaha, NE

      About Me Beauty Expert

      Verified Reviewer

      Pros

      • Lightweight
      • Moisturizes
      • Non-Greasy
      • Smells Great
      • Softens Skin
      • Soothes Skin

      Cons

        Best Uses

        • Daily Use
        • Fine Lines/Wrinkles
        • Sensitive Skin

        Comments about Acyl-Glutathione:

        This product is light and feels great on my skin. I saw noticeable improvement in fine lines within the first week. It doesn't have any strong scent and just glides over my face easily. This is my new "can't live without" Perricone product!

        • Skin Type:
        • Dry
        • Age:
        • 45-59
         
        5.0

        Love it!

        By Claudia

        from Upstate NY

        About Me Beauty Expert

        Verified Reviewer

        Pros

        • Moisturizes
        • More even skin tone
        • Soothes Skin

        Cons

          Best Uses

          • Daily Use
          • Fine Lines/Wrinkles
          • Skin discoloration
          • Uneven Skin Tone

          Comments about Acyl-Glutathione:

          I've been using the product for the weeks now and I'm getting complements on my skin again! I could see the difference after two days use. The lines in my forehead are barely noticeable and the sun spots on my cheeks and brow are gone. I'm amazed at how well this product has worked for me.

          • Skin Type:
          • Dry
          • Age:
          • 45-59

          (1 of 1 customers found this review helpful)

           
          5.0

          Great product!

          By Lala

          from Elmsford, NY

          About Me Minimalist

          Pros

          • Lightweight
          • Moisturizes
          • Non-Greasy
          • Smells Great
          • Softens Skin
          • Soothes Skin

          Cons

            Best Uses

            • Daily Use
            • Fine Lines/Wrinkles
            • Redness/ Blotchiness
            • Sensitive Skin
            • Uneven Skin Tone

            Comments about Acyl-Glutathione:

            I highly recommend this product for sensitive skin. It has even helped my rosacea condition

            • Skin Type:
            • Dry
            • Age:
            • 60+
             
            5.0

            Love, love, love Acy-Glutathion

            By MGP

            from Minnetrista, Minnesota

            About Me Beauty Conscious

            Pros

            • Lightweight
            • Moisturizes
            • Non-Greasy
            • Smells Great
            • Softens Skin
            • Soothes Skin

            Cons

              Best Uses

              • Daily Use
              • Fine Lines/Wrinkles
              • Sensitive Skin
              • Uneven Skin Tone

              Comments about Acyl-Glutathione:

              This product took 15 years off my face. At 72 my young students think I look younger than their 50+ grandmothers.

              • Skin Type:
              • Dry
              • Age:
              • 60+
               
              5.0

              Definitely

              By Mat

              from Hollywood, fl

              About Me Beauty Conscious

              Verified Reviewer

              Pros

              • Incredible radiance
              • Lightweight
              • Moisturizes
              • Non-Greasy
              • Softens Skin
              • Soothes Skin

              Cons

                Best Uses

                • Daily Use
                • Fine Lines/Wrinkles
                • Uneven Skin Tone

                Comments about Acyl-Glutathione:

                I use every morning and I m amazed at the results

                • Skin Type:
                • Dry
                • Age:
                • 45-59
                 
                5.0

                Love This Product!!!

                By Judy the Nana

                from Martinsburg WV

                About Me Beauty Conscious

                Verified Reviewer

                Pros

                • Lightweight
                • Makes my neck feel and appear to be tighter!
                • Moisturizes
                • Non-Greasy
                • Smells Great
                • Softens Skin
                • Soothes Skin

                Cons

                  Best Uses

                  • Daily Use
                  • Enlarged Pores
                  • Fine Lines/Wrinkles
                  • Redness/ Blotchiness
                  • Sensitive Skin
                  • Uneven Skin Tone

                  Comments about Acyl-Glutathione:

                  Love this product! Easy to use and results are easily seen!

                  • Skin Type:
                  • Combination
                  • Age:
                  • 60+

                  (4 of 17 customers found this review helpful)

                   
                  1.0

                  Too pricey

                  By on a budget

                  from VA

                  Comments about Acyl-Glutathione:

                  This product costs too much. I am going to take the advise of others and never buy it so I don't have to give it up later because I can not afford it. Thanks for the warning. Dr Perricone, please give us some affordable products that help us have healthy skin.

                  • Was this a gift?:
                  • No

                  (9 of 13 customers found this review helpful)

                   
                  3.0

                  Canceling my auto refill today :(

                  By Fern

                  from The Glen

                  Verified Reviewer

                  Pros

                  • It is a very nice cream.

                  Cons

                  • I am addicted to it, and now cannot afford it.

                  Best Uses

                  • Base face cream.

                  Comments about Acyl-Glutathione:

                  I don't know if I can actually go through with this. Maybe I'll just get a second job. If I work an extra day a week I think I should be able to afford one jar a month. Don't get hooked to something you cannot afford! "Oh, I'll just try it once.." "Well maybe once more because it's on sale." "Just for my birthday." And on and on. Now I'm cleaning the change out of my car, and under the sofa cushions!

                  • Was this a gift?:
                  • No

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