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DMAE: Unlocking the Secret to the Brain-Beauty Connection

Say hello to DMAE, the ultimate skin-firming ingredient and a serious multitasker. Before we go too deep under the surface, let's first dig in to understanding the Brain-Beauty Connection—one of the key secrets in maintaining a youthful appearance and an agile mind as we age.

The Brain-Beauty Connection

Before we're born (when we're in an embryonic state), the layer of cells that eventually develops into the skin are also responsible for making brain cells. This Brain-Beauty Connection means that what's therapeutic for the brain is also therapeutic for the skin. Conversely, what's beneficial to the skin is also important to the brain. But it doesn't stop there. Each of the highly-targeted foods and nutrients Dr. Perricone recommends for the skin, will also help protect the cardiovascular system, build muscle, strengthen bone, decrease body fat, enhance athletic performance, improve libido and restore that all important joie de vivre; that sense of well-being, happiness and optimism that's so necessary for living life to the fullest.


DMAE—a nutrient near and dear to our hearts (and brain and skin, as well)—is a naturally-occurring substance with significant anti-inflammatory, anti-aging properties. DMAE is found in sardines and anchovies, and small amounts of it are also produced naturally in the human brain. It can also be taken as a nutritional supplement or applied topically to the skin. No matter the method, all three work synergistically for optimum effect.

DMAE and Diet

Let's start with diet. Only one food has the reputation from time immemorial of being a "brain food," and that food is fish—especially fish that is high in DMAE. Given that DMAE is known as a cognitive enhancer, a diet high in this nutrient can help enable you to think more clearly, improve memory and better problem solve. It's also a building block of the neurotransmitter acetylcholine, which—like other neurotransmitters—allows one nerve to communicate with another, or with a muscle. Studies have also shown that DMAE acts as an antioxidant by stabilizing cell membranes, helping to protect them from free radical damage. By raising levels of DMAE in our bodies, we can think more clearly and have greater muscle tone in both face and body.

DMAE and Your Skin

Numerous studies have shown that topical application of DMAE increases the appearance of firmness, tone and lift to the skin. DMAE also improves the appearance of skin elasticity and luminosity, helping to decrease the look of fine lines and wrinkles while brightening skin's appearance and evening out imperfections. Many scientists and researchers in the field of dermatology are studying this remarkable nutrient, and their exciting findings validate what Dr. Perricone has known for decades—DMAE has a unique, important role as a safe and effective strategy to help address the appearance of aging skin.

DMAE and Muscle Tone

When you decide to move any muscle in your body (whether it's to type on the computer or flash a smile), a signal comes from the brain and travels along a nerve until it approaches the appropriate muscle that will do the actual job. At the end of the nerve is a bud that holds a reservoir of neural chemicals, including acetylcholine. The nerves do not actually touch the muscle to make it jump into action; instead, the signal stops a short distance away at a place known as the "neuromuscular junction," just before contact. At this junction, the powerful neurotransmitter acetylcholine is released from the bulb and locks onto special receptors on the muscle that cause the muscle to contract.

Increasing Muscle Tone with DMAE

Our levels of acetylcholine naturally decline as we age, resulting in reduced muscle tone. Instead of staying short and tight, our muscles become elongated and relaxed, resulting in a sagging face and body. One way to help improve this muscle tone is to increase acetylcholine levels, and a good way to do this is by introducing additional DMAE into your system. How? Well, there are four ways to do this:
  1. Eat fish, the only significant dietary source of DMAE
  2. Take DMAE in the form of a nutritional supplement
  3. Apply a high potency, rapidly penetrating DMAE topical lotion to the skin on the face and body
  4. Keep the muscles toned with exercise
Together, they all work synergistically to provide optimum levels of this ultimate skin-firming nutrient in the body.