#5705

Acyl-Glutathione Deep Crease Serum

$185.00
Acyl-Glutathione Deep Crease Serum - Perricone MD
  • Acyl-Glutathione Deep Crease Serum

Images

Acyl-Glutathione Deep Crease Serum - Perricone MD
Formulated with Dr. Perricone’s patented Acyl-Glutathione, this powerful anti-aging treatment is designed to address visible expression lines and creases that appear from repetitive facial movements to help achieve a more youthful looking appearance.
  • Select Color
  • Add to cart options
    • 10% Auto Replenishment
    • 10% Auto Replenishment
    +Add to Wish List

    Need Help? Ask a Skincare Specialist

    Additional Information

    Product Details

    What It Is

    Formulated with Dr. Perricone’s patented Acyl-Glutathione, this powerful anti-aging treatment is designed to address visible expression lines and creases that appear from repetitive facial movements. Over time, these engraved imperfections appear instantly smoothed, making creases appear shallower and erasing the look of furrow creases along the forehead, squinting creases and feathery lines along the lips to help achieve a more youthful looking appearance.

    What It Does
    • Softens the look of facial lines from daily repetitive movements.
    • Visibly improves etched creases making them appear more shallow.
    • Minimizes the appearance of skin imperfections and imparts a beautiful radiance.
    What To Expect

    Due to the science and compounds used in our products the feel and scent may vary.

    Texture

    Serum

    Consistency

    Lightweight

    Scent

    Natural, Aromatic

    Consumer Results

    88% agreed their skin looked more luminous.

    85% said their face took on a more relaxed appearance and had a more pleasant and youthful expression.

    80% saw a smoothing of facial lines and creases by daily repetitive movement and agreed their laughter lines looked shallower.

    Key Sciences

    Acyl-Glutathione

    Scientifically formulated to minimize the appearance of lines and creases while improving skin vitality.

    Neuropeptides

    Scientifically formulated messenger molecules that help boost the appearance of suppleness and firmness.

    Acyl-Glutathione Deep Crease Serum Science

    Ingredients

    Acyl-Glutathione

    Replenishes the body's master antioxidant to minimize the appearance of creases and other signs of accelerated skin aging.

    Neuropeptides

    Highly sophisticated proprietary technology that activates surface renewal to address problems of more mature skin.

    Ingredients

    Water/Aqua/Eau, Glycerin, Tetrahexyldecyl Ascorbate, S-Palmitoylglutathione, Isopropyl Palmitate, Squalane, Butylene Glycol, Cyclopentasiloxane, Cetearyl Alcohol, Glycolic Acid, Glyceryl Stearate, PEG-100 Stearate, Dimethicone, Dimethyl MEA, Cyclohexasiloxane, Ceteareth-20, Fragrance/Parfum, Phenoxyethanol, Zinc Gluconate, Magnesium Aspartate, Caprylyl Glycol, Phosphatidylcholine, Disodium EDTA, Citric Acid, Docosahexaenoic Acid, Sorbic Acid, Linalool, Copper Gluconate, Tetrapeptide-21, Citronellol, Sodium Hyaluronate, Geraniol, Limonene, Acetyl Hexapeptide-8, Pentapeptide-18, Citral.

    Application

    Application

    Dr. Perricone recommends smoothing onto a cleansed face in the morning paying special attention to visible expression lines and creases. Follow with a Perricone MD moisturizer.

    Application Process

    Area

    Face

    Amount

    1 - 2 Pumps

    Frequency

    2x / Day

    Duration

    8 Weeks

    1. Dispense 1 to 2 pumps onto fingertips.
    2. Smooth onto face, paying special attention to visible expression lines and creases.
    3. Use in the morning and evening.
    4. Follow with a Perricone MD moisturizer.

    Videos

    Q&A

    Do you have questions about this product?

    Get answers from real customers and in-house experts with AnswerBox.

    65 Questions | 66 Answers
    Displaying questions 1-10Previous | Next »
    • Q:

      Hello. Does this product actually treat laugh lines or is it a temporary fix l? Will results stop once you stop using it? And how would i incorporate this if I use retin a at night? Thank you!
      Asked on 1/29/2016 by Melissa

      1 answer

      • Perricone MD Skincare Specialist

        A:

        Good question. The Acyl-Deep Crease Serum is an amazing daily spot treatment to be used for laugh lines, crows feet, the "elevens" and forehead area. Over time you will see the appearance of fine lines diminish. You can use day and night under your Retin A or just use in the morning.

        Answered on 3/10/2016 by Perricone MD Skincare Specialist
    • Q:

      What is the percentage of glycolic acid in this product?
      Asked on 10/23/2015 by Ghotsibi from Fresno, Ca

      1 answer

      • Perricone MD Skincare Specialist

        A:

        Good question!

        There is a little over 2% of glycolic acid in the Acyl-Glutathione Deep Crease Serum.

        Have a nice day!

        Answered on 10/26/2015 by Perricone MD Customer Care Specialist from Perricone MD Customer Care
    • Q:

      Hello,
      Would I apply Acyl-Glutathione Deep crease Serum before or after Cold Plasma? And then apply Acyl-Glutathione Creme on top and them the final moisturiser( Neuropepeptide Firming moisturiser)
      Thank you
      Asked on 10/20/2015 by Budde from Ny

      1 answer

      • Perricone MD Skincare Specialist

        A:

        Great question!

        There are five steps to following the Perricone regime and they are:

        1a. Cleanser
        1b. Treatment Mask
        2. Toner or Serum
        3. Exfoliant
        4. Treatment
        5. Moisturizer

        The Acy-Glutathione Deep Crease Serum (Step 2) should be applied first then apply the Cold Plasma (Step 4), follow with the Acyl-Glutathione cream (Step 4) and the moisturizer (NP Firming Moisturizer) (Step 5) should always be applied last.

        Have a nice day!

        Answered on 10/22/2015 by Perricone MD Customer Care Specialist from Perricone MD Customer Care
    • Q:

      I am going to buy acyl-glutathione deep crease serum but wonder if I can use it with the concentrated restorative cream at night or should I rotate using them every other night? I break out with the face firming moisturizer so I use no moisturizer. Any suggestions for that?
      Asked on 8/27/2015 by Kat from TN

      1 answer

      • Perricone MD Skincare Specialist

        A:

        Thank you for your interest in Dr. Perricone's products.

        All of Dr. Perricone's products can be used together and it is perfectly fine to use both the Acyl-Glutathione Deep Crease Serum and the Concentrated Restorative Cream daily or every other day; which ever you prefer.

        Since you are unable to use the Face Finishing Moisturizer I recommend the Hypoallergenic Nourishing Moisturizer from Dr. Perricone's sensitive skin care line.

        Have a nice day!

        Answered on 9/3/2015 by Perricone MD Skincare Specialist from Perricone MD Customer Care
    • Q:

      Hello , I am 22 years old and i lost over 50 lbs recently and im starting to see Jowls or Marionettes around my smile....is this product good for that? Or should I try another Perricone MD product?
      Asked on 6/14/2015 by Angie from new york

      1 answer

      • Perricone MD Skincare Specialist

        A:

        Great question!

        Yes, the Acyl-Glutathione Deep Crease Serum will definitely address the smile lines and expression lines.

        Acyl-Glutathione Deep Crease Serum is a powerful anti-aging treatment designed to address expression lines and creases that appear from repetitive facial movements. Upon first application, these engraved imperfections appear instantly smoothed, making creases appear shallower and erasing the look of furrow creases along the forehead, squinting creases and feathery lines along the lips. Combined with its illuminating effect, this anti-aging serum is the ideal non-invasive alternative to help achieve a more youthful looking appearance.

        Answered on 8/1/2015 by Perricone MD Skincare Specialist from Perricone MD Customer Care
    • Q:

      I have A-G deep crease serum, vit c ester 15,nueropeptide firming moisturizer, chia oil, chloroplasma and blue plasma. Kindly guide me how to use them. Also what r ur most powerful anti aging products. I'm 53 years and have droopy mouth corners, droopy eyelids. Thanks
      Asked on 5/30/2015 by r

      1 answer

      • Perricone MD Skincare Specialist

        A:

        Thank you for contacting Perricone MD.

        There are five steps to following the Perricone regime and they are:

        1. Cleanser
        2. Toner or Serum
        3. Exfoliant
        4. Treatment
        5. Moisturizer

        Please see Application Protocol below:

        AM PRODUCTS PM PRODUCTS
        Cleanser Cleanser
        Chloro Plasma (2-3 times per week) Blue Plasma
        Acyl-Glutathione Deep Crease Serum Acyl-Glutathione Deep Crease
        NP Firming Moisturizer/chia serum NP Firming Moisturizer/chia serum

        The Chia Serum can be mixed with Neuropeptide Firming Moisturizer to provide additional moisture, or it can be used alone without moisturizer.

        I hope this is helpful.

        Answered on 6/12/2015 by Perricone MD Skincare Specialist from Perricone MD Customer Care
    • Q:

      Does this go before Cold Plasma or after? Does this go before Vitamin C Serum? What order do Cold Plasma, Hyalo, Vitamin C Serum, and Acyl-Glutathione go in? Please do not advise me to the protocol page because it's not been helpful thus far.
      Asked on 4/5/2015 by fit3two

      1 answer

      • Perricone MD Skincare Specialist

        A:

        Thank you for contacting Perricone MD.

        There are five steps to following the Perricone regime and they are:

        1. Cleanser
        2. Toner or Serum
        3. Exfoliant – (PM ONLY)
        4. Treatment
        5. Moisturizer

        The Acyl-Glutathione Deep Crease Serum (Step 2) for both AM & PM application.

        The Cold Plasma (Step 4) treatment is always the very first Perricone treatment applied both AM & PM.

        Vitamin C Ester Serum (Step 2) this is an AM serum and since you are also using the Acyl-Glutathione Deep Crease serum I recommend alternating, Use Vitamin C Serum in the AM and the Acyl-serum in the PM.

        Acyl-Glutathione (Step 4) treatment should be applied AM & PM after the Cold Plasma.

        Hyalo Plasma (Step 4) treatment should be applied after the Acyl-Glutathione both AM & PM.

        A moisturizer should always follow last.

        We also have an Application Protocol Sheet listed on our website: www.perriconemd.com; simply click at the top of the page on Customer Service, and to the left you will see a drop down menu, click on "Application Protocol".

        I hope this is helpful.

        Answered on 4/29/2015 by Perricone MD Skincare Specialist from Perricone MD Customer Care
    • Q:

      I bought the Acyl-glutathione Deep Crease serum and it really works,but I get a TERRIBLE headache on my forehead after I use it. I mean blistering headache,I was wondering if this has happened before andwhat in it would cause this. I can't use the product anymore,I can't function if I do.Too bad, I love the results.
      Asked on 2/9/2015 by Julie from Canada

      1 answer

      • Perricone MD Skincare Specialist

        A:

        Thank you for contacting Perricone MD.

        We regret to hear of your experience although we have never received this type of complaint or heard of this occurring after using the Acyl-Glutathione Deep Crease Serum.

        Most people do not have any problem using Dr. Perricone’s products, but there unfortunately is no list of ingredients that can be guaranteed to not disagree. Persons who have sensitive’s should pay careful attention to what they use on their skin. It is virtually impossible to know if, when, or how anyone will react to any cosmetic.

        I recommend discontinuing usage of this product and returning for a refund.

        We have a variety of products that will address your concerns that contain different ingredients and I recommend calling our Customer Service Department (888-823-7837) and requesting a Skin Care Consultation,.

        I hope this is helpful.

        Answered on 2/10/2015 by Perricone MD Skincare Specialist from Perricone MD Customer Care
    • Q:

      I am trying to decide whether I want the Acyl-Glutathione Deep Crease Serum v. the Acyl-Gluthathione. I use the A-G Eye Serum and I love it, I want to use the A-G on my face, but I don't know if I should get the serum or the other A-G product which I assume is also a treatment product and not a moisturizer. Please help as I am not sure what the difference is between those two products. Should they all be used together? Thank you!
      Asked on 1/29/2015 by Katina from Pennsylvania

      1 answer

      • Perricone MD Skincare Specialist

        A:

        Thank you for contacting Perricone MD.

        There are five steps to following the Perricone regime and they are:

        1. Cleanser
        2. Toner or Serum
        3. Exfoliant
        4. Treatment
        5. Moisturizer

        The Acyl-Glutathione Deep Crease Serum (Step 2) is a serum and the Acyl-Glutathione (Step 4) is the treatment.

        If you are only able to purchase one I recommend the Acyl-Glutathione cream which is a powerful treatment that diminishes expression lines, wrinkles and creases.

        This treatment is applied both AM & PM and a moisturizer should always follow last.

        I hope this is helpful.

        Answered on 2/2/2015 by Perricone MD Skincare Specialist from Perricone MD Customer Care
    • Q:

      Hi,
      I'm using Amine Facelift in AM and High Potency Evening Repair at bedtime.

      In the AM prior to putting on makeup, can Acyl-Glutathione Deep Crease Serum be used BEFORE OR AFTER the Amine Facelift to help diminish lines, OR should it NOT be combined with Amine Facelift at all?
      Asked on 1/19/2015 by nu from Northern California

      1 answer

      • Perricone MD Skincare Specialist

        A:

        Great question! The Acyl-Glutathione Deep Crease Serum should be used before your High Potency Amine Face Lift during the day, and before the High Potency Evening Repair at night.

        Answered on 1/26/2015 by Anonymous
    Displaying questions 1-10Previous | Next »

    Do you have a question about this product? 

     

    Reviews

    Reviews

    REVIEW SNAPSHOT®

    by PowerReviews
    Perricone MDAcyl-Glutathione Deep Crease Serum
     
    3.6

    (based on 19 reviews)

    Ratings Distribution

    • 5 Stars

       

      (7)

    • 4 Stars

       

      (6)

    • 3 Stars

       

      (0)

    • 2 Stars

       

      (3)

    • 1 Stars

       

      (3)

    71%

    of respondents would recommend this to a friend.

    Pros

    No Pros

    Cons

    No Cons

    Best Uses

    No Best Uses
      • Was this a gift?:
      • No (17)

    Most Liked Positive Review

     

    Love this!!!

    First, I absolutely love having a product to specifically treat expression lines and creases. Secondly and most importantly, it works!! The day I began to use the product, I was hating marionette...Read complete review

    First, I absolutely love having a product to specifically treat expression lines and creases. Secondly and most importantly, it works!! The day I began to use the product, I was hating marionette lines on my face but I had hope. Three days later, I have jumped back to a point in time when I didn't mind having them. That's huge for me -- from lined to just a bit lined. I massage the product into crease areas as directed. Thank you so much! I have another Perricone MD staple.

    VS

    Most Liked Negative Review

     

    No, I would not recommend this product .

    I use this product exactly as Dr. Perricone suggests. I massage it in to deep creases and wrinkles. I see absolutely no results at all, I, in fact, am returning the product...Read complete review

    I use this product exactly as Dr. Perricone suggests. I massage it in to deep creases and wrinkles. I see absolutely no results at all, I, in fact, am returning the product for something else. It smells good. That is all I can say for the product. It is also very pricey, to do nothing for me. I do love most of the rest of Perricone products. I will call and speak to a skin consultant today.I was just thinking I needed to call about this product, so I am glad for the review. Wish I could have given better, but it does not work for me.
    Thank you

    Reviewed by 19 customers

    Displaying reviews 1-5

    Back to top

    Previous | Next »

    (1 of 1 customers found this review helpful)

     
    2.0

    Repurchase

    By Hoping for improvement

    from md

    Comments about Perricone MD Acyl-Glutathione Deep Crease Serum:

    I have been using this serum for over a month and I am not really seeing any difference. I took a picture before use and after use and my deep lines seem to be still there. I am not sure that this product provided any difference, only a difference in my wallet.

    • Was this a gift?:
    • No

    (2 of 2 customers found this review helpful)

     
    2.0

    Fair product, but too much money.

    By Fern

    from The Glen

    Verified Reviewer

    Comments about Perricone MD Acyl-Glutathione Deep Crease Serum:

    I thought I was paying too much for too little before, and now I know I will not purchase any more of it. I would have bought more if it had been on sale, but instead the price has gone up. I'm not even sure if it makes any difference. Possibly, but I think I can find something just as good for much less money. I am beginning to feel like a cad falling for for this.

    • Was this a gift?:
    • No

    (2 of 2 customers found this review helpful)

     
    4.0

    GREAT PRODUCT

    By blondie

    from Philadelphia, PA

    Comments about Perricone MD Acyl-Glutathione Deep Crease Serum:

    I purchased this product to help with deeper lines (I am in my upper 50's). I found it to be effective in softening my expression wrinkles. I only gave the product 4 stars because of price.

    • Was this a gift?:
    • No

    (2 of 3 customers found this review helpful)

     
    4.0

    It works!

    By Dr. DebbySue

    from Virginia Beach, VA

    Pros

    • It *dissolves* those tiny weblike creases.

    Cons

    • It takes time but is worth the wait.

    Best Uses

      Comments about Perricone MD Acyl-Glutathione Deep Crease Serum:

      I could not believe the difference ten days of use made! You must stick to the routine but it is definitely worth the result!

      • Was this a gift?:
      • No

      (1 of 1 customers found this review helpful)

       
      4.0

      Mixed Review, but...

      By Tn

      from CT

      Comments about Perricone MD Acyl-Glutathione Deep Crease Serum:

      I'm 61 years old and have used Perricone products since they first came out. I've stayed out of the sun all my life and Perricone has kept me virtually wrinkle free - except for the H between the brow and the frown lines. I went through 2 bottles of this product which lasted a very long time. I didn't see great improvement...so I decided against buying the product again. Now, within about 2 months, those lines are SO much worse than before...so I think this is a maintenance product if you start it too late in life. They should manage expectations...However, bottom line, I'm buying it again!

      • Was this a gift?:
      • No

      Displaying reviews 1-5

      Back to top

      Previous | Next »

       
      • You Might Also Like
      • Recently Viewed
      Customer Care

      We want you to be 100% satisfied with your purchase, and stand by the quality of our products. Should you for any reason be unhappy with your purchase we will promptly issue a refund to your credit card or exchange an unsatisfactory product for another one. Please see returns & exchanges for details on how to process.

      Please visit our customer care section for more information on returns and exchanges, how to contact us, and more.
      Learn More

      Shipping & Returns

      At Perricone MD, we offer complimentary standard U.S. shipping and a number of flat fee-based domestic and international options. Simply select the appropriate shipping option for domestic or international delivery during checkout.

      Should you for any reason be unhappy with your purchase, upon product return we will issue a refund to your credit card or exchange an unsatisfactory product for an alternative item.

      For customer care or product inquiries, please call us toll-free at 1-888-823-7837 or email us info@perriconemd.com.

      Monday - Thursday: 7:30AM - Midnight EST
      Friday: 8:30AM - 10:00PM EST
      Saturday & Sunday: 9:00AM - 11:00PM EST
      Complimentary Samples

      All orders include a complimentary choice of three sample packettes.

      Find out more about PerriconeMD.com's variety of complimentary services.

      Learn More