#5705

Acyl-Glutathione Deep Crease Serum

Acyl-Glutathione Deep Crease Serum

$185.00
Acyl-Glutathione Deep Crease Serum
Formulated with Dr. Perricone’s patented Acyl-Glutathione, this powerful anti-aging treatment is designed to address visible expression lines and creases that appear from repetitive facial movements to help achieve a more youthful looking appearance.

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    Product Details
    What It Is

    Formulated with Dr. Perricone’s patented Acyl-Glutathione, this powerful anti-aging treatment is designed to address visible expression lines and creases that appear from repetitive facial movements.. Over time, these engraved imperfections appear instantly smoothed, making creases appear shallower and erasing the look of furrow creases along the forehead, squinting creases and feathery lines along the lips to help achieve a more youthful looking appearance.

    What It Does
    • Softens the look of facial lines from daily repetitive movements.
    • Visibly improves etched creases making them appear more shallow.
    • Minimizes the appearance of skin imperfections and imparts a beautiful radiance.
    What To Expect

    Due to the science and compounds used in our products the feel and scent may vary.

    Texture

    Serum

    Consistency

    Lightweight

    Scent

    Natural, Aromatic

    Consumer Results

    88% agreed their skin looked more luminous.

    85% said their face took on a more relaxed appearance and had a more pleasant and youthful expression.

    80% saw a smoothing of facial lines and creases by daily repetitive movement and agreed their laughter lines looked shallower.

    Key Sciences

    Acyl-Glutathione

    Scientifically formulated to minimize the appearance of lines and creases while improving skin vitality.

    Neuropeptides

    Scientifically formulated messenger molecules that help boost the appearance of suppleness and firmness.

    Acyl-Glutathione Deep Crease Serum Science
    Ingredients
    Acyl-Glutathione

    Replenishes the body's master antioxidant to minimize the appearance of creases and other signs of accelerated skin aging.

    Neuropeptides

    Highly sophisticated proprietary technology that activates surface renewal to address problems of more mature skin.

    Ingredients

    Water/Aqua/Eau, Glycerin, Tetrahexyldecyl Ascorbate, S-Palmitoylglutathione, Isopropyl Palmitate, Squalane, Butylene Glycol, Cyclopentasiloxane, Cetearyl Alcohol, Glycolic Acid, Glyceryl Stearate, PEG-100 Stearate, Dimethicone, Dimethyl MEA, Cyclohexasiloxane, Ceteareth-20, Fragrance/Parfum, Phenoxyethanol, Zinc Gluconate, Magnesium Aspartate, Caprylyl Glycol, Phosphatidylcholine, Disodium EDTA, Citric Acid, Docosahexaenoic Acid, Sorbic Acid, Linalool, Copper Gluconate, Tetrapeptide-21, Citronellol, Sodium Hyaluronate, Geraniol, Limonene, Acetyl Hexapeptide-8, Pentapeptide-18, Citral.

    Application

    Application

    Dr. Perricone recommends smoothing onto a cleansed face in the morning paying special attention to visible expression lines and creases. Follow with a Perricone MD moisturizer.

    Application Process

    Area

    Face

    Amount

    1 - 2 Pumps

    Frequency

    1x / Day

    Duration

    8 Weeks

    1. Dispense 1 pump per eye onto fingertips.
    2. Apply directly to the eye lid up, moving up to the eye brow bone in gentle patting motions.
    3. Apply along crows feet and lower contours of the eyes.
    4. Use in the morning and evening.
    5. Follow with a Perricone MD eye cream.
    Videos
    Q&A

    Do you have questions about this product?

    Get answers from real customers and in-house experts with AnswerBox.

    64 Questions | 65 Answers
    Displaying questions 1-10Previous | Next »
    • Q:

      What is the percentage of glycolic acid in this product?
      Asked on 10/23/2015 by Ghotsibi from Fresno, Ca

      1 answer

      • Perricone MD Skincare Specialist

        A:

        Good question!

        There is a little over 2% of glycolic acid in the Acyl-Glutathione Deep Crease Serum.

        Have a nice day!

        Answered on 10/26/2015 by Perricone MD Customer Care Specialist from Perricone MD Customer Care
    • Q:

      Hello,
      Would I apply Acyl-Glutathione Deep crease Serum before or after Cold Plasma? And then apply Acyl-Glutathione Creme on top and them the final moisturiser( Neuropepeptide Firming moisturiser)
      Thank you
      Asked on 10/20/2015 by Budde from Ny

      1 answer

      • Perricone MD Skincare Specialist

        A:

        Great question!

        There are five steps to following the Perricone regime and they are:

        1a. Cleanser
        1b. Treatment Mask
        2. Toner or Serum
        3. Exfoliant
        4. Treatment
        5. Moisturizer

        The Acy-Glutathione Deep Crease Serum (Step 2) should be applied first then apply the Cold Plasma (Step 4), follow with the Acyl-Glutathione cream (Step 4) and the moisturizer (NP Firming Moisturizer) (Step 5) should always be applied last.

        Have a nice day!

        Answered on 10/22/2015 by Perricone MD Customer Care Specialist from Perricone MD Customer Care
    • Q:

      I am going to buy acyl-glutathione deep crease serum but wonder if I can use it with the concentrated restorative cream at night or should I rotate using them every other night? I break out with the face firming moisturizer so I use no moisturizer. Any suggestions for that?
      Asked on 8/27/2015 by Kat from TN

      1 answer

      • Perricone MD Skincare Specialist

        A:

        Thank you for your interest in Dr. Perricone's products.

        All of Dr. Perricone's products can be used together and it is perfectly fine to use both the Acyl-Glutathione Deep Crease Serum and the Concentrated Restorative Cream daily or every other day; which ever you prefer.

        Since you are unable to use the Face Finishing Moisturizer I recommend the Hypoallergenic Nourishing Moisturizer from Dr. Perricone's sensitive skin care line.

        Have a nice day!

        Answered on 9/3/2015 by Perricone MD Skincare Specialist from Perricone MD Customer Care
    • Q:

      Hello , I am 22 years old and i lost over 50 lbs recently and im starting to see Jowls or Marionettes around my smile....is this product good for that? Or should I try another Perricone MD product?
      Asked on 6/14/2015 by Angie from new york

      1 answer

      • Perricone MD Skincare Specialist

        A:

        Great question!

        Yes, the Acyl-Glutathione Deep Crease Serum will definitely address the smile lines and expression lines.

        Acyl-Glutathione Deep Crease Serum is a powerful anti-aging treatment designed to address expression lines and creases that appear from repetitive facial movements. Upon first application, these engraved imperfections appear instantly smoothed, making creases appear shallower and erasing the look of furrow creases along the forehead, squinting creases and feathery lines along the lips. Combined with its illuminating effect, this anti-aging serum is the ideal non-invasive alternative to help achieve a more youthful looking appearance.

        Answered on 8/1/2015 by Perricone MD Skincare Specialist from Perricone MD Customer Care
    • Q:

      I have A-G deep crease serum, vit c ester 15,nueropeptide firming moisturizer, chia oil, chloroplasma and blue plasma. Kindly guide me how to use them. Also what r ur most powerful anti aging products. I'm 53 years and have droopy mouth corners, droopy eyelids. Thanks
      Asked on 5/30/2015 by r

      1 answer

      • Perricone MD Skincare Specialist

        A:

        Thank you for contacting Perricone MD.

        There are five steps to following the Perricone regime and they are:

        1. Cleanser
        2. Toner or Serum
        3. Exfoliant
        4. Treatment
        5. Moisturizer

        Please see Application Protocol below:

        AM PRODUCTS PM PRODUCTS
        Cleanser Cleanser
        Chloro Plasma (2-3 times per week) Blue Plasma
        Acyl-Glutathione Deep Crease Serum Acyl-Glutathione Deep Crease
        NP Firming Moisturizer/chia serum NP Firming Moisturizer/chia serum

        The Chia Serum can be mixed with Neuropeptide Firming Moisturizer to provide additional moisture, or it can be used alone without moisturizer.

        I hope this is helpful.

        Answered on 6/12/2015 by Perricone MD Skincare Specialist from Perricone MD Customer Care
    • Q:

      Does this go before Cold Plasma or after? Does this go before Vitamin C Serum? What order do Cold Plasma, Hyalo, Vitamin C Serum, and Acyl-Glutathione go in? Please do not advise me to the protocol page because it's not been helpful thus far.
      Asked on 4/5/2015 by fit3two

      1 answer

      • Perricone MD Skincare Specialist

        A:

        Thank you for contacting Perricone MD.

        There are five steps to following the Perricone regime and they are:

        1. Cleanser
        2. Toner or Serum
        3. Exfoliant – (PM ONLY)
        4. Treatment
        5. Moisturizer

        The Acyl-Glutathione Deep Crease Serum (Step 2) for both AM & PM application.

        The Cold Plasma (Step 4) treatment is always the very first Perricone treatment applied both AM & PM.

        Vitamin C Ester Serum (Step 2) this is an AM serum and since you are also using the Acyl-Glutathione Deep Crease serum I recommend alternating, Use Vitamin C Serum in the AM and the Acyl-serum in the PM.

        Acyl-Glutathione (Step 4) treatment should be applied AM & PM after the Cold Plasma.

        Hyalo Plasma (Step 4) treatment should be applied after the Acyl-Glutathione both AM & PM.

        A moisturizer should always follow last.

        We also have an Application Protocol Sheet listed on our website: www.perriconemd.com; simply click at the top of the page on Customer Service, and to the left you will see a drop down menu, click on "Application Protocol".

        I hope this is helpful.

        Answered on 4/29/2015 by Perricone MD Skincare Specialist from Perricone MD Customer Care
    • Q:

      I bought the Acyl-glutathione Deep Crease serum and it really works,but I get a TERRIBLE headache on my forehead after I use it. I mean blistering headache,I was wondering if this has happened before andwhat in it would cause this. I can't use the product anymore,I can't function if I do.Too bad, I love the results.
      Asked on 2/9/2015 by Julie from Canada

      1 answer

      • Perricone MD Skincare Specialist

        A:

        Thank you for contacting Perricone MD.

        We regret to hear of your experience although we have never received this type of complaint or heard of this occurring after using the Acyl-Glutathione Deep Crease Serum.

        Most people do not have any problem using Dr. Perricone’s products, but there unfortunately is no list of ingredients that can be guaranteed to not disagree. Persons who have sensitive’s should pay careful attention to what they use on their skin. It is virtually impossible to know if, when, or how anyone will react to any cosmetic.

        I recommend discontinuing usage of this product and returning for a refund.

        We have a variety of products that will address your concerns that contain different ingredients and I recommend calling our Customer Service Department (888-823-7837) and requesting a Skin Care Consultation,.

        I hope this is helpful.

        Answered on 2/10/2015 by Perricone MD Skincare Specialist from Perricone MD Customer Care
    • Q:

      I am trying to decide whether I want the Acyl-Glutathione Deep Crease Serum v. the Acyl-Gluthathione. I use the A-G Eye Serum and I love it, I want to use the A-G on my face, but I don't know if I should get the serum or the other A-G product which I assume is also a treatment product and not a moisturizer. Please help as I am not sure what the difference is between those two products. Should they all be used together? Thank you!
      Asked on 1/29/2015 by Katina from Pennsylvania

      1 answer

      • Perricone MD Skincare Specialist

        A:

        Thank you for contacting Perricone MD.

        There are five steps to following the Perricone regime and they are:

        1. Cleanser
        2. Toner or Serum
        3. Exfoliant
        4. Treatment
        5. Moisturizer

        The Acyl-Glutathione Deep Crease Serum (Step 2) is a serum and the Acyl-Glutathione (Step 4) is the treatment.

        If you are only able to purchase one I recommend the Acyl-Glutathione cream which is a powerful treatment that diminishes expression lines, wrinkles and creases.

        This treatment is applied both AM & PM and a moisturizer should always follow last.

        I hope this is helpful.

        Answered on 2/2/2015 by Perricone MD Skincare Specialist from Perricone MD Customer Care
    • Q:

      Hi,
      I'm using Amine Facelift in AM and High Potency Evening Repair at bedtime.

      In the AM prior to putting on makeup, can Acyl-Glutathione Deep Crease Serum be used BEFORE OR AFTER the Amine Facelift to help diminish lines, OR should it NOT be combined with Amine Facelift at all?
      Asked on 1/19/2015 by nu from Northern California

      1 answer

      • Perricone MD Skincare Specialist

        A:

        Great question! The Acyl-Glutathione Deep Crease Serum should be used before your High Potency Amine Face Lift during the day, and before the High Potency Evening Repair at night.

        Answered on 1/26/2015 by Anonymous
    • Q:

      Is there a shelf life for this product?
      Asked on 1/12/2015 by Rox from Rutherford, NJ 07070

      1 answer

      • Perricone MD Skincare Specialist

        A:

        Thank you for contacting Perricone MD.

        All of Dr. Perricone's skin care products are good for up to 2 years from date of purchase.

        If you purchased product in 2014 they will expire 2016 and if purchased 2015 they will expire 2017.

        I hope this is helpful.

        Have a nice day!

        Answered on 1/12/2015 by Perricone MD Skincare Specialist from Perricone MD Customer Care
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    Reviews

    Reviews

    REVIEW SNAPSHOT®

    by PowerReviews
    Perricone MDAcyl-Glutathione Deep Crease Serum
     
    3.7

    (based on 14 reviews)

    Ratings Distribution

    • 5 Stars

       

      (7)

    • 4 Stars

       

      (3)

    • 3 Stars

       

      (0)

    • 2 Stars

       

      (1)

    • 1 Stars

       

      (3)

    77%

    of respondents would recommend this to a friend.

    Pros

    No Pros

    Cons

    No Cons

    Best Uses

    No Best Uses
      • Was this a gift?:
      • No (12)

    Most Liked Positive Review

     

    Love this!!!

    First, I absolutely love having a product to specifically treat expression lines and creases. Secondly and most importantly, it works!! The day I began to use the product, I was hating marionette...Read complete review

    First, I absolutely love having a product to specifically treat expression lines and creases. Secondly and most importantly, it works!! The day I began to use the product, I was hating marionette lines on my face but I had hope. Three days later, I have jumped back to a point in time when I didn't mind having them. That's huge for me -- from lined to just a bit lined. I massage the product into crease areas as directed. Thank you so much! I have another Perricone MD staple.

    VS

    Most Liked Negative Review

     

    No, I would not recommend this product .

    I use this product exactly as Dr. Perricone suggests. I massage it in to deep creases and wrinkles. I see absolutely no results at all, I, in fact, am returning the product...Read complete review

    I use this product exactly as Dr. Perricone suggests. I massage it in to deep creases and wrinkles. I see absolutely no results at all, I, in fact, am returning the product for something else. It smells good. That is all I can say for the product. It is also very pricey, to do nothing for me. I do love most of the rest of Perricone products. I will call and speak to a skin consultant today.I was just thinking I needed to call about this product, so I am glad for the review. Wish I could have given better, but it does not work for me.
    Thank you

    Reviewed by 14 customers

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    (1 of 1 customers found this review helpful)

     
    1.0

    Trying to find out if I got defective product

    By OJ

    from Arizona

    Verified Reviewer

    Pros

      Cons

      • Like Water

      Best Uses

        Comments about Perricone MD Acyl-Glutathione Deep Crease Serum:

        Was expecting a creamy product but my serum drips out like water. Left voice message with Perricone customer service after being on hold for 10 minutes (still waiting for call back). I need to determine if this is a defective product that has been excessively watered down to the point it drips out of the bottle or is it supposed to be like this.

        • Was this a gift?:
        • No

        (2 of 3 customers found this review helpful)

         
        5.0

        A Miracle for Parenthesis, 11's, Forehead

        By Glamorous Gorgeous & Natural!

        from Miami Beach

        Verified Reviewer

        Comments about Perricone MD Acyl-Glutathione Deep Crease Serum:

        This product works exactly as described, and....from the 1ST TIME it's used!!! I use on Parenthesis, 11's, and Forehead. I used 2x daily. It GREATLY softens Parenthesis, 11's, Forehead IN A SIMILAR WAY AS INJECTIONS (juvederm for parenthesis & botox for 11's and forehead). It is a MIRACLE. The 1st time I applied it at night, when I woke up, the results were outstanding, as if I had injections (which I had in the past so I know from experience)!! I have been using A-G SERUM 6 months, and apply in this order: Serum Prep, Cold Plasma, A-G SERUM, and then at night I add Dr P's Sensitive Moisture, and day time I layer Hyalo Plasma and then my drug store brand moisture 30spf sunscreen. 3 months ago I bought HYALO PLASMA which is drop-dead amazing for PLUMPNESS ON THE ENTIRE ENTIRE ENTIRE CHEEK REGION. A-G SERUM works great with or without also adding HYALO PLASMA. A-G SERUM IS A HIGHLY TARGETED APPLICATION DIRECTLY ON THE ( ), 11's & FOREHEAD to MINIMIZE THOSE PRECISELY FORMED LINES. Whereas if you also add afterwards HYALO PLASMA which is to be used on the ENTIRE cheek area,HYALO GIVES BABY-LIKE PLUMPNESS AS IF YOU TOOK A TIRE PUMP AND PLUMPED UP YOUR ENTIRE FACE....CHEEKS. The combo of A-G SERUM which is for the SPECIFIC lines & HYALO PLASMA afterward for entire cheek plumpness (convexity) is outstanding beyond belief. A-G takes 5-10 Years off. A-G PLUS HYALO takes 10-15 Years off. If you could see me, you would believe me. Thank You Dr P. No Injections Needed!

        • Was this a gift?:
        • No

        (5 of 5 customers found this review helpful)

         
        4.0

        Amazing Results~

        By Vee

        from Los angeles, ca

        Comments about Perricone MD Acyl-Glutathione Deep Crease Serum:

        I recently go a sample of this AMAZING serum from a store clerk and have been using very little of it for about a week and a half. I must say,this serum does exactly what is claims! I also got a sample of the Neuropeptide Firming Moisturizer, as well. I use the Crease Serum under the Firming Moisturizer morning and night. Not only are the lines on my forehead diminishing, my complexion has lightened up too,the acne scars that I have on both cheeks, have softened DRAMATICALLY! My make up looks smooth. I will be purchasing both products! Ladies, I know Perricone is expensive, but they work! I know that not all products work on everyone, the results and timing of results vary. If you have doubts, get samples before you purchase his line. I gave it four stars due to the high price, but if it works, it's worth it.

        • Was this a gift?:
        • No

        (3 of 4 customers found this review helpful)

         
        4.0

        Good product.

        By Kat

        from NEW YORK

        Comments about Perricone MD Acyl-Glutathione Deep Crease Serum:

        I use the product before bed and in the morning. People have offered me comments, but I don't know how true it is. I don't see any improvements myself. I say I have a new skin regimen but they don't believe me. Cons, dogs lick my face, like I'm food. What's up with that?

        • Was this a gift?:
        • No

        (2 of 2 customers found this review helpful)

         
        2.0

        Expected more from such an expensive product

        By Didi

        from australia

        Comments about Perricone MD Acyl-Glutathione Deep Crease Serum:

        Used it morning and night for 2 weeks and I've seen no change at all. Will not buy it again

        • Was this a gift?:
        • No

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        Customer Care

        We want you to be 100% satisfied with your purchase, and stand by the quality of our products. Should you for any reason be unhappy with your purchase we will promptly issue a refund to your credit card or exchange an unsatisfactory product for another one. Please see returns & exchanges for details on how to process.

        Please visit our customer care section for more information on returns and exchanges, how to contact us, and more.
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        For customer care or product inquiries, please call us toll-free at 1-888-823-7837 or email us info@perriconemd.com.

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