#5705

Acyl-Glutathione Deep Crease Serum

Acyl-Glutathione Deep Crease Serum - Perricone MD
  • Acyl-Glutathione Deep Crease Serum

Images

Acyl-Glutathione Deep Crease Serum - Perricone MD
Formulated with Dr. Perricone’s patented Acyl-Glutathione, this powerful anti-aging treatment is designed to address visible expression lines and creases that appear from repetitive facial movements to help achieve a more youthful looking appearance. See Details
$ 185.00 166.50
Add to cart options

Additional Information

Product Details

What It Is

Formulated with Dr. Perricone’s patented Acyl-Glutathione, this powerful anti-aging treatment is designed to address visible expression lines and creases that appear from repetitive facial movements. Over time, these engraved imperfections appear instantly smoothed, making creases appear shallower and erasing the look of furrow creases along the forehead, squinting creases and feathery lines along the lips to help achieve a more youthful looking appearance.

What It Does
  • Softens the look of facial lines from daily repetitive movements.
  • Visibly improves etched creases making them appear more shallow.
  • Minimizes the appearance of skin imperfections and imparts a beautiful radiance.
What To Expect

Due to the science and compounds used in our products the feel and scent may vary.

Texture

Serum

Consistency

Lightweight

Scent

Natural, Aromatic

Consumer Results

88% agreed their skin looked more luminous.

85% said their face took on a more relaxed appearance and had a more pleasant and youthful expression.

80% saw a smoothing of facial lines and creases by daily repetitive movement and agreed their laughter lines looked shallower.

Key Sciences

Acyl-Glutathione

Scientifically formulated to minimize the appearance of lines and creases while improving skin vitality.

Neuropeptides

Scientifically formulated messenger molecules that help boost the appearance of suppleness and firmness.

Acyl-Glutathione Deep Crease Serum Science

Ingredients

Acyl-Glutathione

Replenishes the body's master antioxidant to minimize the appearance of creases and other signs of accelerated skin aging.

Neuropeptides

Highly sophisticated proprietary technology that activates surface renewal to address problems of more mature skin.

Ingredients

Water/Aqua/Eau, Glycerin, Tetrahexyldecyl Ascorbate, S-Palmitoylglutathione, Isopropyl Palmitate, Squalane, Butylene Glycol, Cyclopentasiloxane, Cetearyl Alcohol, Glycolic Acid, Glyceryl Stearate, PEG-100 Stearate, Dimethicone, Dimethyl MEA, Cyclohexasiloxane, Ceteareth-20, Fragrance/Parfum, Phenoxyethanol, Zinc Gluconate, Magnesium Aspartate, Caprylyl Glycol, Phosphatidylcholine, Disodium EDTA, Citric Acid, Docosahexaenoic Acid, Sorbic Acid, Linalool, Copper Gluconate, Tetrapeptide-21, Citronellol, Sodium Hyaluronate, Geraniol, Limonene, Acetyl Hexapeptide-8, Pentapeptide-18, Citral.

Application

Application

Dr. Perricone recommends smoothing onto a cleansed face in the morning paying special attention to visible expression lines and creases. Follow with a Perricone MD moisturizer.

Application Process

Area

Face

Amount

1 - 2 Pumps

Frequency

2x / Day

Duration

8 Weeks

  1. Dispense 1 to 2 pumps onto fingertips.
  2. Smooth onto face, paying special attention to visible expression lines and creases.
  3. Use in the morning and evening.
  4. Follow with a Perricone MD moisturizer.

Videos

Q&A

Do you have questions about this product?

Get answers from real customers and in-house experts with AnswerBox.

65 Questions | 66 Answers
Displaying questions 1-10Previous | Next »
  • Q:

    Hello. Does this product actually treat laugh lines or is it a temporary fix l? Will results stop once you stop using it? And how would i incorporate this if I use retin a at night? Thank you!
    Asked on 1/29/2016 by Melissa

    1 answer

    • Perricone MD Skincare Specialist

      A:

      Good question. The Acyl-Deep Crease Serum is an amazing daily spot treatment to be used for laugh lines, crows feet, the "elevens" and forehead area. Over time you will see the appearance of fine lines diminish. You can use day and night under your Retin A or just use in the morning.

      Answered on 3/10/2016 by Perricone MD Skincare Specialist
  • Q:

    What is the percentage of glycolic acid in this product?
    Asked on 10/23/2015 by Ghotsibi from Fresno, Ca

    1 answer

    • Staff Reviewer

      A:

      Good question!

      There is a little over 2% of glycolic acid in the Acyl-Glutathione Deep Crease Serum.

      Have a nice day!

      Answered on 10/26/2015 by Perricone MD Customer Care Specialist from Perricone MD Customer Care
  • Q:

    Hello,
    Would I apply Acyl-Glutathione Deep crease Serum before or after Cold Plasma? And then apply Acyl-Glutathione Creme on top and them the final moisturiser( Neuropepeptide Firming moisturiser)
    Thank you
    Asked on 10/20/2015 by Budde from Ny

    1 answer

    • Staff Reviewer

      A:

      Great question!

      There are five steps to following the Perricone regime and they are:

      1a. Cleanser
      1b. Treatment Mask
      2. Toner or Serum
      3. Exfoliant
      4. Treatment
      5. Moisturizer

      The Acy-Glutathione Deep Crease Serum (Step 2) should be applied first then apply the Cold Plasma (Step 4), follow with the Acyl-Glutathione cream (Step 4) and the moisturizer (NP Firming Moisturizer) (Step 5) should always be applied last.

      Have a nice day!

      Answered on 10/22/2015 by Perricone MD Customer Care Specialist from Perricone MD Customer Care
  • Q:

    I am going to buy acyl-glutathione deep crease serum but wonder if I can use it with the concentrated restorative cream at night or should I rotate using them every other night? I break out with the face firming moisturizer so I use no moisturizer. Any suggestions for that?
    Asked on 8/27/2015 by Kat from TN

    1 answer

    • Staff Reviewer

      A:

      Thank you for your interest in Dr. Perricone's products.

      All of Dr. Perricone's products can be used together and it is perfectly fine to use both the Acyl-Glutathione Deep Crease Serum and the Concentrated Restorative Cream daily or every other day; which ever you prefer.

      Since you are unable to use the Face Finishing Moisturizer I recommend the Hypoallergenic Nourishing Moisturizer from Dr. Perricone's sensitive skin care line.

      Have a nice day!

      Answered on 9/3/2015 by Perricone MD Skincare Specialist from Perricone MD Customer Care
  • Q:

    Hello , I am 22 years old and i lost over 50 lbs recently and im starting to see Jowls or Marionettes around my smile....is this product good for that? Or should I try another Perricone MD product?
    Asked on 6/14/2015 by Angie from new york

    1 answer

    • Staff Reviewer

      A:

      Great question!

      Yes, the Acyl-Glutathione Deep Crease Serum will definitely address the smile lines and expression lines.

      Acyl-Glutathione Deep Crease Serum is a powerful anti-aging treatment designed to address expression lines and creases that appear from repetitive facial movements. Upon first application, these engraved imperfections appear instantly smoothed, making creases appear shallower and erasing the look of furrow creases along the forehead, squinting creases and feathery lines along the lips. Combined with its illuminating effect, this anti-aging serum is the ideal non-invasive alternative to help achieve a more youthful looking appearance.

      Answered on 8/1/2015 by Perricone MD Skincare Specialist from Perricone MD Customer Care
  • Q:

    I have A-G deep crease serum, vit c ester 15,nueropeptide firming moisturizer, chia oil, chloroplasma and blue plasma. Kindly guide me how to use them. Also what r ur most powerful anti aging products. I'm 53 years and have droopy mouth corners, droopy eyelids. Thanks
    Asked on 5/30/2015 by r

    1 answer

    • Staff Reviewer

      A:

      Thank you for contacting Perricone MD.

      There are five steps to following the Perricone regime and they are:

      1. Cleanser
      2. Toner or Serum
      3. Exfoliant
      4. Treatment
      5. Moisturizer

      Please see Application Protocol below:

      AM PRODUCTS PM PRODUCTS
      Cleanser Cleanser
      Chloro Plasma (2-3 times per week) Blue Plasma
      Acyl-Glutathione Deep Crease Serum Acyl-Glutathione Deep Crease
      NP Firming Moisturizer/chia serum NP Firming Moisturizer/chia serum

      The Chia Serum can be mixed with Neuropeptide Firming Moisturizer to provide additional moisture, or it can be used alone without moisturizer.

      I hope this is helpful.

      Answered on 6/12/2015 by Perricone MD Skincare Specialist from Perricone MD Customer Care
  • Q:

    Does this go before Cold Plasma or after? Does this go before Vitamin C Serum? What order do Cold Plasma, Hyalo, Vitamin C Serum, and Acyl-Glutathione go in? Please do not advise me to the protocol page because it's not been helpful thus far.
    Asked on 4/5/2015 by fit3two

    1 answer

    • Staff Reviewer

      A:

      Thank you for contacting Perricone MD.

      There are five steps to following the Perricone regime and they are:

      1. Cleanser
      2. Toner or Serum
      3. Exfoliant – (PM ONLY)
      4. Treatment
      5. Moisturizer

      The Acyl-Glutathione Deep Crease Serum (Step 2) for both AM & PM application.

      The Cold Plasma (Step 4) treatment is always the very first Perricone treatment applied both AM & PM.

      Vitamin C Ester Serum (Step 2) this is an AM serum and since you are also using the Acyl-Glutathione Deep Crease serum I recommend alternating, Use Vitamin C Serum in the AM and the Acyl-serum in the PM.

      Acyl-Glutathione (Step 4) treatment should be applied AM & PM after the Cold Plasma.

      Hyalo Plasma (Step 4) treatment should be applied after the Acyl-Glutathione both AM & PM.

      A moisturizer should always follow last.

      We also have an Application Protocol Sheet listed on our website: www.perriconemd.com; simply click at the top of the page on Customer Service, and to the left you will see a drop down menu, click on "Application Protocol".

      I hope this is helpful.

      Answered on 4/29/2015 by Perricone MD Skincare Specialist from Perricone MD Customer Care
  • Q:

    I bought the Acyl-glutathione Deep Crease serum and it really works,but I get a TERRIBLE headache on my forehead after I use it. I mean blistering headache,I was wondering if this has happened before andwhat in it would cause this. I can't use the product anymore,I can't function if I do.Too bad, I love the results.
    Asked on 2/9/2015 by Julie from Canada

    1 answer

    • Staff Reviewer

      A:

      Thank you for contacting Perricone MD.

      We regret to hear of your experience although we have never received this type of complaint or heard of this occurring after using the Acyl-Glutathione Deep Crease Serum.

      Most people do not have any problem using Dr. Perricone’s products, but there unfortunately is no list of ingredients that can be guaranteed to not disagree. Persons who have sensitive’s should pay careful attention to what they use on their skin. It is virtually impossible to know if, when, or how anyone will react to any cosmetic.

      I recommend discontinuing usage of this product and returning for a refund.

      We have a variety of products that will address your concerns that contain different ingredients and I recommend calling our Customer Service Department (888-823-7837) and requesting a Skin Care Consultation,.

      I hope this is helpful.

      Answered on 2/10/2015 by Perricone MD Skincare Specialist from Perricone MD Customer Care
  • Q:

    I am trying to decide whether I want the Acyl-Glutathione Deep Crease Serum v. the Acyl-Gluthathione. I use the A-G Eye Serum and I love it, I want to use the A-G on my face, but I don't know if I should get the serum or the other A-G product which I assume is also a treatment product and not a moisturizer. Please help as I am not sure what the difference is between those two products. Should they all be used together? Thank you!
    Asked on 1/29/2015 by Katina from Pennsylvania

    1 answer

    • Staff Reviewer

      A:

      Thank you for contacting Perricone MD.

      There are five steps to following the Perricone regime and they are:

      1. Cleanser
      2. Toner or Serum
      3. Exfoliant
      4. Treatment
      5. Moisturizer

      The Acyl-Glutathione Deep Crease Serum (Step 2) is a serum and the Acyl-Glutathione (Step 4) is the treatment.

      If you are only able to purchase one I recommend the Acyl-Glutathione cream which is a powerful treatment that diminishes expression lines, wrinkles and creases.

      This treatment is applied both AM & PM and a moisturizer should always follow last.

      I hope this is helpful.

      Answered on 2/2/2015 by Perricone MD Skincare Specialist from Perricone MD Customer Care
  • Q:

    Hi,
    I'm using Amine Facelift in AM and High Potency Evening Repair at bedtime.

    In the AM prior to putting on makeup, can Acyl-Glutathione Deep Crease Serum be used BEFORE OR AFTER the Amine Facelift to help diminish lines, OR should it NOT be combined with Amine Facelift at all?
    Asked on 1/19/2015 by nu from Northern California

    1 answer

    • Staff Reviewer

      A:

      Great question! The Acyl-Glutathione Deep Crease Serum should be used before your High Potency Amine Face Lift during the day, and before the High Potency Evening Repair at night.

      Answered on 1/26/2015 by Anonymous
Displaying questions 1-10Previous | Next »

Do you have a question about this product? 

 

Reviews

Reviews

REVIEW SNAPSHOT®

by PowerReviews
Acyl-Glutathione Deep Crease Serum
 
3.7

(based on 28 reviews)

Ratings Distribution

  • 5 Stars

     

    (12)

  • 4 Stars

     

    (7)

  • 3 Stars

     

    (1)

  • 2 Stars

     

    (4)

  • 1 Stars

     

    (4)

69%

of respondents would recommend this to a friend.

Pros

  • Lightweight (5)
  • Non-greasy (5)
  • Smells great (3)
  • Soothes skin (3)

Cons

No Cons

Best Uses

  • Fine lines/wrinkles (5)
  • Daily use (4)
    • Reviewer Profile:
    • Beauty conscious (4)
    • Skin Type:
    • Combination (3)
    • Was this a gift?:
    • No (19)

Most Liked Positive Review

 

Love this!!!

First, I absolutely love having a product to specifically treat expression lines and creases. Secondly and most importantly, it works!! The day I began to use the product, I was hating marionette...Read complete review

First, I absolutely love having a product to specifically treat expression lines and creases. Secondly and most importantly, it works!! The day I began to use the product, I was hating marionette lines on my face but I had hope. Three days later, I have jumped back to a point in time when I didn't mind having them. That's huge for me -- from lined to just a bit lined. I massage the product into crease areas as directed. Thank you so much! I have another Perricone MD staple.

VS

Most Liked Negative Review

 

No, I would not recommend this product .

I use this product exactly as Dr. Perricone suggests. I massage it in to deep creases and wrinkles. I see absolutely no results at all, I, in fact, am returning the product...Read complete review

I use this product exactly as Dr. Perricone suggests. I massage it in to deep creases and wrinkles. I see absolutely no results at all, I, in fact, am returning the product for something else. It smells good. That is all I can say for the product. It is also very pricey, to do nothing for me. I do love most of the rest of Perricone products. I will call and speak to a skin consultant today.I was just thinking I needed to call about this product, so I am glad for the review. Wish I could have given better, but it does not work for me.
Thank you

Reviewed by 28 customers

Displaying reviews 1-10

Back to top

Previous | Next »

 
4.0

Love it but pump is often defective

By Laurie

from Laguna Niguel, CA

About Me Beauty Conscious

Verified Reviewer

Pros

  • Soothes Skin

Cons

    Best Uses

      Comments about Acyl-Glutathione Deep Crease Serum:

      This is a holy-grail product that I've been using for years to minimize/improve marionette lines. The only negative is that the pump arrives defective at times. (3x for me, once before several years ago direct from Perricone, this one direct from Perricone, and once before from a retailer. I enlisted my DH this time for a 2nd opinion and he said no way, it's definitely defective/not going to work. I'm call to request a new pump, but it's disappointing because I'm out of it. It's wasteful (plus looses potency) if opening the bottle top to access. I recommend buying it in-person at a retailer and testing the pump before you purchase. All of that said, IT WORKS and is a great product.

      • Skin Type:
      • Combination
      • Age:
      • 45-59
       
      5.0

      who needs botox?!

      By Amy looking younger

      from New York, NY

      About Me Minimalist

      Verified Reviewer

      Pros

      • Lightweight
      • Reduces appearance of forehead wrinkles

      Cons

        Best Uses

        • Fine Lines/Wrinkles

        Comments about Acyl-Glutathione Deep Crease Serum:

        I refuse to use botox but hate being one of the few out there without that smooth unwrinkled forehead that comes with injections. This product is the best of both worlds - my forehead looks natural, moves with my expressions, but the wrinkles are so softened that I'm not self-conscious in the slightest. I got so confident that I figured it was just me and for a few months went without when I ran out -- my wrinkles all returned in full force, and I ran out and bought more. Now I look good again. Don't fret too much about the price, you just need a dollop in the morning and a dollop at night - lasts me between 9 months and a year. when I ran out

        • Skin Type:
        • Dry
        • Age:
        • 45-59
         
        5.0

        Love love love this product!

        By T

        from Ohio

        About Me Beauty Conscious

        Pros

        • Lightweight
        • Non-Greasy

        Cons

          Best Uses

          • Daily Use
          • Fine Lines/Wrinkles

          Comments about Acyl-Glutathione Deep Crease Serum:

          Have been using this product for a few years. Started a little later with skin care but this product helps. A little goes a long ways. I use this both day and night.

          • Skin Type:
          • Combination
          • Age:
          • 45-59
           
          2.0

          So Watery

          By Tray from Cali

          from SAN Diego, ca

          Comments about Acyl-Glutathione Deep Crease Serum:

          This stuff is too runny. If you use the pump, it squirts out EVERYWHERE. I've had to resort to unscrewing the top and just using the tube or my finger to apply some.

          • Skin Type:
          • Oily
          • Age:
          • 45-59
           
          5.0

          Line Eraser..

          By Lady L

          from North Smithfield RI

          About Me Beauty Conscious

          Verified Reviewer

          Pros

          • Lightweight
          • Non-Greasy

          Cons

            Best Uses

            • Daily Use
            • Fine Lines/Wrinkles

            Comments about Acyl-Glutathione Deep Crease Serum:

            I have been using this product for a few years and won't be without it. I smile a lot and this product has reduced my laugh lines to where they are so minimal that they are almost nonexistent. I also use this serum on all target areas of the face. The more you use it, the better you skin gets and it lasts a very long time. This serum is my Botox in a Bottle. Thank you Perricone MD..

            • Skin Type:
            • Combination
            • Age:
            • 45-59

            (0 of 1 customers found this review helpful)

             
            5.0

            Wonderful Product!!!

            By bellabean

            from Media, PA

            About Me Minimalist

            Verified Reviewer

            Pros

            • Lightweight
            • Moisturizes
            • Non-Greasy
            • Smells Great
            • Softens Skin
            • Soothes Skin

            Cons

              Best Uses

              • Daily Use
              • Fine Lines/Wrinkles

              Comments about Acyl-Glutathione Deep Crease Serum:

              Work well on deep lines/wrinkles.

              • Skin Type:
              • Normal
              • Age:
              • 45-59
               
              5.0

              EXCELLENT PRODUCT--REDUCES LINES AND WRINKLES IMMEDIATELY.

              By Judy

              from Kailua, Hawaii

              About Me Beauty Conscious

              Verified Reviewer

              Pros

              • Lightweight
              • Moisturizes
              • Non-Greasy
              • Smells Great
              • Softens Skin
              • Soothes Skin

              Cons

                Best Uses

                • Daily Use
                • Enlarged Pores
                • Fine Lines/Wrinkles
                • Sensitive Skin

                Comments about Acyl-Glutathione Deep Crease Serum:

                Use after daily shower.

                • Skin Type:
                • Normal
                • Age:
                • 60+

                (1 of 1 customers found this review helpful)

                 
                3.0

                So so

                By AngieA

                from San Francisco

                Comments about Acyl-Glutathione Deep Crease Serum:

                I'm 30, but have some wrinkles between my eyebrows. I bought it because it is the first product that I found specifically targeting expression lines. I did not see any difference first 3 months, then after 3 months I started seeing improvements. So if you bought this product and do not see any difference, use it religiously for more than 3 months to see the difference. It is a long time to wait compare to other products on the market, but if you already spent that much money, mind as well just use it. It does help eventually. Just because it takes so long for the result to show, I probably would not recommend this product.

                • Was this a gift?:
                • No

                (2 of 2 customers found this review helpful)

                 
                1.0

                No, I would not purchase again

                By Lori D

                from Rhode Island

                Pros

                • None for me

                Cons

                • Very watery

                Best Uses

                  Comments about Acyl-Glutathione Deep Crease Serum:

                  Had high hopes for this "targeted product" but I am very disappointed...was initially surprised that the product was so watery, expected a better quality serum, I have used this product for over one month, and have not seen the slightest difference...

                  • Was this a gift?:
                  • No

                  (1 of 1 customers found this review helpful)

                   
                  2.0

                  Repurchase

                  By Hoping for improvement

                  from md

                  Comments about Acyl-Glutathione Deep Crease Serum:

                  I have been using this serum for over a month and I am not really seeing any difference. I took a picture before use and after use and my deep lines seem to be still there. I am not sure that this product provided any difference, only a difference in my wallet.

                  • Was this a gift?:
                  • No

                  Displaying reviews 1-10

                  Back to top

                  Previous | Next »

                   
                  Ask A Skincare Specialist

                  We want you to be 100% satisfied with your purchase, and stand by the quality of our products. Should you for any reason be unhappy with your purchase we will promptly issue a refund to your credit card or exchange an unsatisfactory product for another one. Please see returns & exchanges for details on how to process.

                  Highly trained Perricone MD experts ready to assist you. Speak with a consultant today
                  1.888.823.7837

                  Shipping & Returns

                  At Perricone MD, we offer complimentary standard U.S. shipping and a number of flat fee-based domestic and international options. Simply select the appropriate shipping option for domestic or international delivery during checkout.

                  Should you for any reason be unhappy with your purchase, upon product return we will issue a refund to your credit card or exchange an unsatisfactory product for an alternative item.

                  Complimentary Samples

                  All orders include a complimentary choice of three sample packettes.

                  Find out more about PerriconeMD.com's variety of complimentary services.

                  Learn More